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B2G6J1

- NADK_LACRJ

UniProt

B2G6J1 - NADK_LACRJ

Protein

NAD kinase

Gene

nadK

Organism
Lactobacillus reuteri (strain JCM 1112)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (10 Jun 2008)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei45 – 451Proton acceptorUniRule annotation
    Binding sitei147 – 1471NADUniRule annotation
    Binding sitei149 – 1491NADUniRule annotation
    Binding sitei184 – 1841NAD; via carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi45 – 462NADUniRule annotation
    Nucleotide bindingi121 – 1222NADUniRule annotation
    Nucleotide bindingi160 – 1656NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLREU557433:GHNR-601-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:LAR_0557
    OrganismiLactobacillus reuteri (strain JCM 1112)
    Taxonomic identifieri557433 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000009150: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 270270NAD kinasePRO_1000120870Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi557433.LAR_0557.

    Structurei

    3D structure databases

    ProteinModelPortaliB2G6J1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000275803.
    KOiK00858.
    OMAiIQMSEIA.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B2G6J1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRIGIYNNET AESQRVTKVL KTEMKRAGLT YVEKNPEVVI TIGGDGTLLS    50
    AFHHYQKDLN NIRFVGIHTG HLGFYTDWRS FEIDDLVDSL VKDSGQAVSY 100
    PLLDMKATYS DGQIENYIAL NESTIRNVTR TMVCDVFINN HLFENFRGDG 150
    LCISTPTGST AYNKSVGGAI VDPNSVGFQL AEMASLNNRV FRTLGSPIIF 200
    GADAELILRL RDENGHVLTC DRDQWMLKSE KERYLTELSY KVSKQRIYFA 250
    QYRHNNFWNR VKDSFIGGVH 270
    Length:270
    Mass (Da):30,667
    Last modified:June 10, 2008 - v1
    Checksum:i29EED5A958A1BDCA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP007281 Genomic DNA. Translation: BAG25073.1.
    RefSeqiYP_001841553.1. NC_010609.1.

    Genome annotation databases

    EnsemblBacteriaiBAG25073; BAG25073; LAR_0557.
    GeneIDi6230442.
    KEGGilrf:LAR_0557.
    PATRICi22258435. VBILacReu111271_0593.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP007281 Genomic DNA. Translation: BAG25073.1 .
    RefSeqi YP_001841553.1. NC_010609.1.

    3D structure databases

    ProteinModelPortali B2G6J1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 557433.LAR_0557.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAG25073 ; BAG25073 ; LAR_0557 .
    GeneIDi 6230442.
    KEGGi lrf:LAR_0557.
    PATRICi 22258435. VBILacReu111271_0593.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000275803.
    KOi K00858.
    OMAi IQMSEIA.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci LREU557433:GHNR-601-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genome analysis of Lactobacillus reuteri and Lactobacillus fermentum reveal a genomic island for reuterin and cobalamin production."
      Morita H., Toh H., Fukuda S., Horikawa H., Oshima K., Suzuki T., Murakami M., Hisamatsu S., Kato Y., Takizawa T., Fukuoka H., Yoshimura T., Itoh K., O'Sullivan D.J., McKay L.L., Ohno H., Kikuchi J., Masaoka T., Hattori M.
      DNA Res. 15:151-161(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JCM 1112.

    Entry informationi

    Entry nameiNADK_LACRJ
    AccessioniPrimary (citable) accession number: B2G6J1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3