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B2G5A9

- FTHS_LACRJ

UniProt

B2G5A9 - FTHS_LACRJ

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Protein

Formate--tetrahydrofolate ligase

Gene
fhs, LAR_0125
Organism
Lactobacillus reuteri (strain JCM 1112)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi62 – 698ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLREU557433:GHNR-127-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:LAR_0125
OrganismiLactobacillus reuteri (strain JCM 1112)
Taxonomic identifieri557433 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000009150: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 553553Formate--tetrahydrofolate ligaseUniRule annotationPRO_1000196812Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi557433.LAR_0125.

Structurei

3D structure databases

ProteinModelPortaliB2G5A9.
SMRiB2G5A9. Positions 3-551.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2G5A9-1 [UniParc]FASTAAdd to Basket

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MTDIEIADQA TLEPITEIAE KLGLSEDEIE QYGKYKAKID LNVKPLPDKK    50
HKLILVTSIN PTPAGEGKST VLIGLGDALN QLNYQTTIAM REPSMGPVFG 100
IKGGATGGGY SQVVPMEDIN LNFTGDLHAL TSANNTLAAL IDNYIMRDNA 150
MNLDPRRIIW KRVEDVNDRA LRNVVTGLGG PMAGVPRETG FDITAASELM 200
AILCLSTSLH DLKERISRIV VGYTYDKEPV TVGQLNFQDA ITIILKDALK 250
PNLVQTLDHT PTIVHGGPFA NIAHGCNSVL ATQTALNLSD YTVTEAGFGA 300
DLGGEKFLDI KQRVLGKHPD AIVIVATVRA LEYNGGAKLA DLNEENLDAL 350
KKGMANLNRH IKNMQLYGLP IVVAINHFVS DTDKEIQMIK DDCAKQNVEA 400
ILTDAWAKGG KGTHDLANKV VELADSPSEF THIYDVQVDD LQTKLEKIAK 450
QIYGAKEVSF SRKAQNQLKR FAKYGWNDLP VCIAKTQYSF TDDQKQLGAP 500
TDFTFHIREL VPKIGAGFVV ALAGNMMTMP GLPKEPAAVN MMIDDNGKIT 550
GLF 553
Length:553
Mass (Da):60,252
Last modified:June 10, 2008 - v1
Checksum:i191BBFE9E0FB534D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP007281 Genomic DNA. Translation: BAG24641.1.
RefSeqiYP_001841121.1. NC_010609.1.

Genome annotation databases

EnsemblBacteriaiBAG24641; BAG24641; LAR_0125.
GeneIDi6230187.
KEGGilrf:LAR_0125.
PATRICi22257432. VBILacReu111271_0134.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP007281 Genomic DNA. Translation: BAG24641.1 .
RefSeqi YP_001841121.1. NC_010609.1.

3D structure databases

ProteinModelPortali B2G5A9.
SMRi B2G5A9. Positions 3-551.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 557433.LAR_0125.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAG24641 ; BAG24641 ; LAR_0125 .
GeneIDi 6230187.
KEGGi lrf:LAR_0125.
PATRICi 22257432. VBILacReu111271_0134.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci LREU557433:GHNR-127-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genome analysis of Lactobacillus reuteri and Lactobacillus fermentum reveal a genomic island for reuterin and cobalamin production."
    Morita H., Toh H., Fukuda S., Horikawa H., Oshima K., Suzuki T., Murakami M., Hisamatsu S., Kato Y., Takizawa T., Fukuoka H., Yoshimura T., Itoh K., O'Sullivan D.J., McKay L.L., Ohno H., Kikuchi J., Masaoka T., Hattori M.
    DNA Res. 15:151-161(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCM 1112.

Entry informationi

Entry nameiFTHS_LACRJ
AccessioniPrimary (citable) accession number: B2G5A9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: May 14, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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