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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Lactobacillus reuteri (strain JCM 1112)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi62 – 69ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processOne-carbon metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:LAR_0125
OrganismiLactobacillus reuteri (strain JCM 1112)
Taxonomic identifieri557433 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001968121 – 553Formate--tetrahydrofolate ligaseAdd BLAST553

Structurei

3D structure databases

ProteinModelPortaliB2G5A9.
SMRiB2G5A9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000040280.
KOiK01938.
OMAiCGEIMTM.

Family and domain databases

CDDicd00477. FTHFS. 1 hit.
HAMAPiMF_01543. FTHFS. 1 hit.
InterProiView protein in InterPro
IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF01268. FTHFS. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.

Sequencei

Sequence statusi: Complete.

B2G5A9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDIEIADQA TLEPITEIAE KLGLSEDEIE QYGKYKAKID LNVKPLPDKK
60 70 80 90 100
HKLILVTSIN PTPAGEGKST VLIGLGDALN QLNYQTTIAM REPSMGPVFG
110 120 130 140 150
IKGGATGGGY SQVVPMEDIN LNFTGDLHAL TSANNTLAAL IDNYIMRDNA
160 170 180 190 200
MNLDPRRIIW KRVEDVNDRA LRNVVTGLGG PMAGVPRETG FDITAASELM
210 220 230 240 250
AILCLSTSLH DLKERISRIV VGYTYDKEPV TVGQLNFQDA ITIILKDALK
260 270 280 290 300
PNLVQTLDHT PTIVHGGPFA NIAHGCNSVL ATQTALNLSD YTVTEAGFGA
310 320 330 340 350
DLGGEKFLDI KQRVLGKHPD AIVIVATVRA LEYNGGAKLA DLNEENLDAL
360 370 380 390 400
KKGMANLNRH IKNMQLYGLP IVVAINHFVS DTDKEIQMIK DDCAKQNVEA
410 420 430 440 450
ILTDAWAKGG KGTHDLANKV VELADSPSEF THIYDVQVDD LQTKLEKIAK
460 470 480 490 500
QIYGAKEVSF SRKAQNQLKR FAKYGWNDLP VCIAKTQYSF TDDQKQLGAP
510 520 530 540 550
TDFTFHIREL VPKIGAGFVV ALAGNMMTMP GLPKEPAAVN MMIDDNGKIT

GLF
Length:553
Mass (Da):60,252
Last modified:June 10, 2008 - v1
Checksum:i191BBFE9E0FB534D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007281 Genomic DNA. Translation: BAG24641.1.
RefSeqiWP_003669710.1. NC_010609.1.

Genome annotation databases

EnsemblBacteriaiBAG24641; BAG24641; LAR_0125.
GeneIDi5189700.
KEGGilrf:LAR_0125.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiFTHS_LACRJ
AccessioniPrimary (citable) accession number: B2G5A9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: July 5, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families