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B2G5A9

- FTHS_LACRJ

UniProt

B2G5A9 - FTHS_LACRJ

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Lactobacillus reuteri (strain JCM 1112)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi62 – 698ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLREU557433:GHNR-127-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:LAR_0125
OrganismiLactobacillus reuteri (strain JCM 1112)
Taxonomic identifieri557433 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000009150: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 553553Formate--tetrahydrofolate ligasePRO_1000196812Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi557433.LAR_0125.

Structurei

3D structure databases

ProteinModelPortaliB2G5A9.
SMRiB2G5A9. Positions 3-551.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2G5A9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDIEIADQA TLEPITEIAE KLGLSEDEIE QYGKYKAKID LNVKPLPDKK
60 70 80 90 100
HKLILVTSIN PTPAGEGKST VLIGLGDALN QLNYQTTIAM REPSMGPVFG
110 120 130 140 150
IKGGATGGGY SQVVPMEDIN LNFTGDLHAL TSANNTLAAL IDNYIMRDNA
160 170 180 190 200
MNLDPRRIIW KRVEDVNDRA LRNVVTGLGG PMAGVPRETG FDITAASELM
210 220 230 240 250
AILCLSTSLH DLKERISRIV VGYTYDKEPV TVGQLNFQDA ITIILKDALK
260 270 280 290 300
PNLVQTLDHT PTIVHGGPFA NIAHGCNSVL ATQTALNLSD YTVTEAGFGA
310 320 330 340 350
DLGGEKFLDI KQRVLGKHPD AIVIVATVRA LEYNGGAKLA DLNEENLDAL
360 370 380 390 400
KKGMANLNRH IKNMQLYGLP IVVAINHFVS DTDKEIQMIK DDCAKQNVEA
410 420 430 440 450
ILTDAWAKGG KGTHDLANKV VELADSPSEF THIYDVQVDD LQTKLEKIAK
460 470 480 490 500
QIYGAKEVSF SRKAQNQLKR FAKYGWNDLP VCIAKTQYSF TDDQKQLGAP
510 520 530 540 550
TDFTFHIREL VPKIGAGFVV ALAGNMMTMP GLPKEPAAVN MMIDDNGKIT

GLF
Length:553
Mass (Da):60,252
Last modified:June 10, 2008 - v1
Checksum:i191BBFE9E0FB534D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP007281 Genomic DNA. Translation: BAG24641.1.
RefSeqiYP_001841121.1. NC_010609.1.

Genome annotation databases

EnsemblBacteriaiBAG24641; BAG24641; LAR_0125.
GeneIDi6230187.
KEGGilrf:LAR_0125.
PATRICi22257432. VBILacReu111271_0134.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP007281 Genomic DNA. Translation: BAG24641.1 .
RefSeqi YP_001841121.1. NC_010609.1.

3D structure databases

ProteinModelPortali B2G5A9.
SMRi B2G5A9. Positions 3-551.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 557433.LAR_0125.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAG24641 ; BAG24641 ; LAR_0125 .
GeneIDi 6230187.
KEGGi lrf:LAR_0125.
PATRICi 22257432. VBILacReu111271_0134.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci LREU557433:GHNR-127-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genome analysis of Lactobacillus reuteri and Lactobacillus fermentum reveal a genomic island for reuterin and cobalamin production."
    Morita H., Toh H., Fukuda S., Horikawa H., Oshima K., Suzuki T., Murakami M., Hisamatsu S., Kato Y., Takizawa T., Fukuoka H., Yoshimura T., Itoh K., O'Sullivan D.J., McKay L.L., Ohno H., Kikuchi J., Masaoka T., Hattori M.
    DNA Res. 15:151-161(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCM 1112.

Entry informationi

Entry nameiFTHS_LACRJ
AccessioniPrimary (citable) accession number: B2G5A9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: October 1, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3