B2G590 (DEOB_LACRJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphopentomutase
EC=5.4.2.7

Alternative name(s):
Phosphodeoxyribomutase

Gene names

Name:	deoB
Ordered Locus Names:	LAR_0106

Organism

Lactobacillus reuteri (strain JCM 1112) [Complete proteome] [HAMAP]

Taxonomic identifier

557433 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Lactobacillaceae › Lactobacillus › Lactobacillus reuteri

Protein attributes

Sequence length	397 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Phosphotransfer between the C1 and C5 carbon atoms of pentose By similarity. HAMAP-Rule MF_00740
Catalytic activity	Alpha-D-ribose 1-phosphate = D-ribose 5-phosphate. HAMAP-Rule MF_00740 2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-alpha-D-ribose 5-phosphate. HAMAP-Rule MF_00740
Cofactor	Binds 1 or 2 manganese ions Potential.
Pathway	Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II): step 1/3. HAMAP-Rule MF_00740
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the phosphopentomutase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Manganese Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	5-phosphoribose 1-diphosphate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway cellular metabolic compound salvage Inferred from electronic annotation. Source: InterPro deoxyribonucleotide catabolic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	magnesium ion binding Inferred from electronic annotation. Source: InterPro manganese ion binding Inferred from electronic annotation. Source: HAMAP phosphopentomutase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 397	397	Phosphopentomutase HAMAP-Rule MF_00740		PRO_1000133085
Sites
	Metal binding	12	1	Manganese By similarity
	Metal binding	294	1	Manganese By similarity
	Metal binding	330	1	Manganese By similarity
	Metal binding	331	1	Manganese By similarity
	Metal binding	342	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	B2G590 [UniParc]. Last modified June 10, 2008. Version 1. Checksum: 2966262C77B20EC8	FASTA	397	44,003
	10 20 30 40 50 60 MSYKRVFVIV MDSVGTGAAH DAAKFDDVGS DTLGHVGEYY KGALKLPNLG KLGISNLRDT 70 80 90 100 110 120 PIEGVPVADP AIGDYGKMEE ISAGKDSMDG HWEMMGLPVM KPLSTFPNGF PQEIVDKLEK 130 140 150 160 170 180 FSGRKVIVNK PYSGTEVIHD YGERQMETGE LILYTSGDSV MQIAAHEDVI PVEELYKICE 190 200 210 220 230 240 YARTLVNGPE YTVGRIIARP YVGPDKDHFT RTANRHDFSL KPIGETDMDR LRAAGYDVIG 250 260 270 280 290 300 VGKINDIFSG EGIDKGYHNE SNMDGMDHVD EVMKQDFTGF CFTNLVDFDA MYGHRRNPKG 310 320 330 340 350 360 FGQALMDFDK RLGNVLDEMK PDDLLMITAD HGNDPGFKGT DHTRENVPLL VYSPSMNKPN 370 380 390 QSLGVRKTFS DLGATILENF NVEPVKGTSF YKEISND

References

[1]

"Comparative genome analysis of Lactobacillus reuteri and Lactobacillus fermentum reveal a genomic island for reuterin and cobalamin production." Morita H., Toh H., Fukuda S., Horikawa H., Oshima K., Suzuki T., Murakami M., Hisamatsu S., Kato Y., Takizawa T., Fukuoka H., Yoshimura T., Itoh K., O'Sullivan D.J., McKay L.L., Ohno H., Kikuchi J., Masaoka T., Hattori M. DNA Res. 15:151-161(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JCM 1112.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP007281 Genomic DNA. Translation: BAG24622.1.
RefSeq	YP_001841102.1. NC_010609.1.
3D structure databases
ProteinModelPortal	B2G590.
ModBase	Search...
Protein-protein interaction databases
STRING	557433.LAR_0106.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAG24622; BAG24622; LAR_0106.
GeneID	6230168.
KEGG	lrf:LAR_0106.
PATRIC	22257394. VBILacReu111271_0115.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1015.
HOGENOM	HOG000008159.
KO	K01839.
OMA	PNMAKLG.
ProtClustDB	PRK05362.
Enzyme and pathway databases
BioCyc	LREU557433:GHNR-107-MONOMER.
UniPathway	UPA00087; UER00173.
Family and domain databases
Gene3D	3.30.70.1250. 1 hit. 3.40.720.10. 2 hits.
HAMAP	MF_00740. Phosphopentomut.
InterPro	IPR017849. Alkaline_Pase-like_a/b/a. IPR017850. Alkaline_phosphatase_core. IPR010045. DeoB. IPR006124. Metalloenzyme. IPR024052. Phosphopentomutase_DeoB_cap. [Graphical view]
Pfam	PF01676. Metalloenzyme. 1 hit. [Graphical view]
PIRSF	PIRSF001491. Ppentomutase. 1 hit.
SUPFAM	SSF53649. Alkaline_phosphatase_core. 1 hit. SSF143856. SSF143856. 1 hit.
TIGRFAMs	TIGR01696. deoB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DEOB_LACRJ

Accession

Primary (citable) accession number: B2G590

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	June 10, 2008
Last modified:	May 1, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program