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B2FQE7

- GCSP_STRMK

UniProt

B2FQE7 - GCSP_STRMK

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Stenotrophomonas maltophilia (strain K279a)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (10 Jun 2008)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciSMAL522373:GJE8-3461-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:Smlt3579
    OrganismiStenotrophomonas maltophilia (strain K279a)
    Taxonomic identifieri522373 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeStenotrophomonasStenotrophomonas maltophilia group
    ProteomesiUP000008840: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 955955Glycine dehydrogenase (decarboxylating)PRO_1000132460Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei702 – 7021N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi522373.Smlt3579.

    Structurei

    3D structure databases

    ProteinModelPortaliB2FQE7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiERRDICL.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B2FQE7-1 [UniParc]FASTAAdd to Basket

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    MSQNTPSLRE LEHHNAFVER HIGPNDAEIA QMLDVVGHAS LDAMTDAIVP    50
    AKIKSPAPLA LPESMTEVQA LAKIRAIADK NTVLRSFIGQ GYYGTHTPNV 100
    ILRNILENPA WYTAYTPYQA EISQGRMEAL INFQTLCADL TGMEIANASL 150
    LDEATAAAEA MTLAKRSAKS KSDTFFVHDA VHPQTLELLR TRAEPMGIVL 200
    RVGTPAEALE AEAFGLLLQY PDTFGQVGDY KALVDAVHAR GGLVAVATDL 250
    LALTLLAAPG EWGADIVVGN SQRFGVPFGF GGPHAAFMAC RDAYKRSMPG 300
    RLIGVSIDAQ GNPAYRLTLQ TREQHIRREK ATSNICTAQV LLAVMASMYA 350
    VYHGPEGLTR IARRTHRLAS ILAAALRNAG VQVGGDFFDT LHVTGVHADE 400
    IHAKARAAGY NLRAIDSDSV GISLDETTTR ADIVAVAAVF GASLDVDALD 450
    ASTADALPAG LLRQSAFLTH PVFNTHHSEH ELLRYLRSLA DKDLAMDRTM 500
    IPLGSCTMKL NATAEMIPVT WPEFSQIHPL VPADQALGYK ELIDTLEAML 550
    VECTGYDAVS LQPNSGAQGE YAGLLAIRAY HRSRGEGHRD ICLIPDSAHG 600
    TNPASAQMCG MKVVVTKTDA NGNVDVEDIR LNAEKYSDRL AAIMMTYPST 650
    HGVFEEEVVE ICEIIHKHGG QVYTDGANMN ALVGVAKPGK WGSDVSHLNL 700
    HKTFCIPHGG GGPGVGPCAV KEHLAPFLPG KLGDNGPVGM VSAASFGSAS 750
    ILPISWMYIA MMGREGLRKA TQVAQLNANY IAKRLAPHFK TLYTGRNGLV 800
    AHECILDVRP LEKTSGIGAE DVAKRLIDFG FHAPTLSFPV AGTLMVEPTE 850
    SESLHELDRF IDAMIQIREE ITAIEDGRLD REDNPLKNAP HTATAVTASE 900
    WTHAYPRELA AFPLASLKQS KYWPPVARVD NVYGDKNVMC ACIPVDAYKD 950
    DEVEA 955
    Length:955
    Mass (Da):102,998
    Last modified:June 10, 2008 - v1
    Checksum:i9AF7C403FAA3C8FC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM743169 Genomic DNA. Translation: CAQ46996.1.
    RefSeqiWP_005414179.1. NC_010943.1.
    YP_001973285.1. NC_010943.1.

    Genome annotation databases

    EnsemblBacteriaiCAQ46996; CAQ46996; Smlt3579.
    GeneIDi6394970.
    KEGGisml:Smlt3579.
    PATRICi23702617. VBISteMal45202_3361.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM743169 Genomic DNA. Translation: CAQ46996.1 .
    RefSeqi WP_005414179.1. NC_010943.1.
    YP_001973285.1. NC_010943.1.

    3D structure databases

    ProteinModelPortali B2FQE7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 522373.Smlt3579.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAQ46996 ; CAQ46996 ; Smlt3579 .
    GeneIDi 6394970.
    KEGGi sml:Smlt3579.
    PATRICi 23702617. VBISteMal45202_3361.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi ERRDICL.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci SMAL522373:GJE8-3461-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome, comparative and functional analysis of Stenotrophomonas maltophilia reveals an organism heavily shielded by drug resistance determinants."
      Crossman L.C., Gould V.C., Dow J.M., Vernikos G.S., Okazaki A., Sebaihia M., Saunders D., Arrowsmith C., Carver T., Peters N., Adlem E., Kerhornou A., Lord A., Murphy L., Seeger K., Squares R., Rutter S., Quail M.A.
      , Rajandream M.A., Harris D., Churcher C., Bentley S.D., Parkhill J., Thomson N.R., Avison M.B.
      Genome Biol. 9:R74.1-R74.13(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K279a.

    Entry informationi

    Entry nameiGCSP_STRMK
    AccessioniPrimary (citable) accession number: B2FQE7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3