Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Stenotrophomonas maltophilia (strain K279a)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciSMAL522373:G1GK1-5697-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Smlt3579
OrganismiStenotrophomonas maltophilia (strain K279a)
Taxonomic identifieri522373 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeStenotrophomonasStenotrophomonas maltophilia group
Proteomesi
  • UP000008840 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001324601 – 955Glycine dehydrogenase (decarboxylating)Add BLAST955

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei702N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiB2FQE7

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi522373.Smlt3579

Structurei

3D structure databases

ProteinModelPortaliB2FQE7
SMRiB2FQE7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CBI Bacteria
COG0403 LUCA
COG1003 LUCA
HOGENOMiHOG000239369
KOiK00281
OMAiQTMVCDL

Family and domain databases

CDDicd00613 GDC-P, 2 hits
Gene3Di3.40.640.10, 2 hits
3.90.1150.10, 1 hit
HAMAPiMF_00711 GcvP, 1 hit
InterProiView protein in InterPro
IPR003437 GcvP
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 2 hits
SUPFAMiSSF53383 SSF53383, 3 hits
TIGRFAMsiTIGR00461 gcvP, 1 hit

Sequencei

Sequence statusi: Complete.

B2FQE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQNTPSLRE LEHHNAFVER HIGPNDAEIA QMLDVVGHAS LDAMTDAIVP
60 70 80 90 100
AKIKSPAPLA LPESMTEVQA LAKIRAIADK NTVLRSFIGQ GYYGTHTPNV
110 120 130 140 150
ILRNILENPA WYTAYTPYQA EISQGRMEAL INFQTLCADL TGMEIANASL
160 170 180 190 200
LDEATAAAEA MTLAKRSAKS KSDTFFVHDA VHPQTLELLR TRAEPMGIVL
210 220 230 240 250
RVGTPAEALE AEAFGLLLQY PDTFGQVGDY KALVDAVHAR GGLVAVATDL
260 270 280 290 300
LALTLLAAPG EWGADIVVGN SQRFGVPFGF GGPHAAFMAC RDAYKRSMPG
310 320 330 340 350
RLIGVSIDAQ GNPAYRLTLQ TREQHIRREK ATSNICTAQV LLAVMASMYA
360 370 380 390 400
VYHGPEGLTR IARRTHRLAS ILAAALRNAG VQVGGDFFDT LHVTGVHADE
410 420 430 440 450
IHAKARAAGY NLRAIDSDSV GISLDETTTR ADIVAVAAVF GASLDVDALD
460 470 480 490 500
ASTADALPAG LLRQSAFLTH PVFNTHHSEH ELLRYLRSLA DKDLAMDRTM
510 520 530 540 550
IPLGSCTMKL NATAEMIPVT WPEFSQIHPL VPADQALGYK ELIDTLEAML
560 570 580 590 600
VECTGYDAVS LQPNSGAQGE YAGLLAIRAY HRSRGEGHRD ICLIPDSAHG
610 620 630 640 650
TNPASAQMCG MKVVVTKTDA NGNVDVEDIR LNAEKYSDRL AAIMMTYPST
660 670 680 690 700
HGVFEEEVVE ICEIIHKHGG QVYTDGANMN ALVGVAKPGK WGSDVSHLNL
710 720 730 740 750
HKTFCIPHGG GGPGVGPCAV KEHLAPFLPG KLGDNGPVGM VSAASFGSAS
760 770 780 790 800
ILPISWMYIA MMGREGLRKA TQVAQLNANY IAKRLAPHFK TLYTGRNGLV
810 820 830 840 850
AHECILDVRP LEKTSGIGAE DVAKRLIDFG FHAPTLSFPV AGTLMVEPTE
860 870 880 890 900
SESLHELDRF IDAMIQIREE ITAIEDGRLD REDNPLKNAP HTATAVTASE
910 920 930 940 950
WTHAYPRELA AFPLASLKQS KYWPPVARVD NVYGDKNVMC ACIPVDAYKD

DEVEA
Length:955
Mass (Da):102,998
Last modified:June 10, 2008 - v1
Checksum:i9AF7C403FAA3C8FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM743169 Genomic DNA Translation: CAQ46996.1
RefSeqiWP_005414179.1, NC_010943.1

Genome annotation databases

EnsemblBacteriaiCAQ46996; CAQ46996; Smlt3579
GeneIDi6394970
KEGGisml:Smlt3579
PATRICifig|522373.3.peg.3361

Similar proteinsi

Entry informationi

Entry nameiGCSP_STRMK
AccessioniPrimary (citable) accession number: B2FQE7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: May 23, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health