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B2FQE7 (GCSP_STRMK) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:Smlt3579
OrganismStenotrophomonas maltophilia (strain K279a) [Complete proteome] [HAMAP]
Taxonomic identifier522373 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeStenotrophomonasStenotrophomonas maltophilia group

Protein attributes

Sequence length955 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 955955Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000132460

Amino acid modifications

Modified residue7021N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
B2FQE7 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: 9AF7C403FAA3C8FC

FASTA955102,998
        10         20         30         40         50         60 
MSQNTPSLRE LEHHNAFVER HIGPNDAEIA QMLDVVGHAS LDAMTDAIVP AKIKSPAPLA 

        70         80         90        100        110        120 
LPESMTEVQA LAKIRAIADK NTVLRSFIGQ GYYGTHTPNV ILRNILENPA WYTAYTPYQA 

       130        140        150        160        170        180 
EISQGRMEAL INFQTLCADL TGMEIANASL LDEATAAAEA MTLAKRSAKS KSDTFFVHDA 

       190        200        210        220        230        240 
VHPQTLELLR TRAEPMGIVL RVGTPAEALE AEAFGLLLQY PDTFGQVGDY KALVDAVHAR 

       250        260        270        280        290        300 
GGLVAVATDL LALTLLAAPG EWGADIVVGN SQRFGVPFGF GGPHAAFMAC RDAYKRSMPG 

       310        320        330        340        350        360 
RLIGVSIDAQ GNPAYRLTLQ TREQHIRREK ATSNICTAQV LLAVMASMYA VYHGPEGLTR 

       370        380        390        400        410        420 
IARRTHRLAS ILAAALRNAG VQVGGDFFDT LHVTGVHADE IHAKARAAGY NLRAIDSDSV 

       430        440        450        460        470        480 
GISLDETTTR ADIVAVAAVF GASLDVDALD ASTADALPAG LLRQSAFLTH PVFNTHHSEH 

       490        500        510        520        530        540 
ELLRYLRSLA DKDLAMDRTM IPLGSCTMKL NATAEMIPVT WPEFSQIHPL VPADQALGYK 

       550        560        570        580        590        600 
ELIDTLEAML VECTGYDAVS LQPNSGAQGE YAGLLAIRAY HRSRGEGHRD ICLIPDSAHG 

       610        620        630        640        650        660 
TNPASAQMCG MKVVVTKTDA NGNVDVEDIR LNAEKYSDRL AAIMMTYPST HGVFEEEVVE 

       670        680        690        700        710        720 
ICEIIHKHGG QVYTDGANMN ALVGVAKPGK WGSDVSHLNL HKTFCIPHGG GGPGVGPCAV 

       730        740        750        760        770        780 
KEHLAPFLPG KLGDNGPVGM VSAASFGSAS ILPISWMYIA MMGREGLRKA TQVAQLNANY 

       790        800        810        820        830        840 
IAKRLAPHFK TLYTGRNGLV AHECILDVRP LEKTSGIGAE DVAKRLIDFG FHAPTLSFPV 

       850        860        870        880        890        900 
AGTLMVEPTE SESLHELDRF IDAMIQIREE ITAIEDGRLD REDNPLKNAP HTATAVTASE 

       910        920        930        940        950 
WTHAYPRELA AFPLASLKQS KYWPPVARVD NVYGDKNVMC ACIPVDAYKD DEVEA 

« Hide

References

[1]"The complete genome, comparative and functional analysis of Stenotrophomonas maltophilia reveals an organism heavily shielded by drug resistance determinants."
Crossman L.C., Gould V.C., Dow J.M., Vernikos G.S., Okazaki A., Sebaihia M., Saunders D., Arrowsmith C., Carver T., Peters N., Adlem E., Kerhornou A., Lord A., Murphy L., Seeger K., Squares R., Rutter S., Quail M.A. expand/collapse author list , Rajandream M.A., Harris D., Churcher C., Bentley S.D., Parkhill J., Thomson N.R., Avison M.B.
Genome Biol. 9:R74.1-R74.13(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K279a.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM743169 Genomic DNA. Translation: CAQ46996.1.
RefSeqYP_001973285.1. NC_010943.1.

3D structure databases

ProteinModelPortalB2FQE7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING522373.Smlt3579.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAQ46996; CAQ46996; Smlt3579.
GeneID6394970.
KEGGsml:Smlt3579.
PATRIC23702617. VBISteMal45202_3361.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAERRDICL.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycSMAL522373:GJE8-3461-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_STRMK
AccessionPrimary (citable) accession number: B2FQE7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families