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B2FQE7

- GCSP_STRMK

UniProt

B2FQE7 - GCSP_STRMK

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, Smlt3579
Organism
Stenotrophomonas maltophilia (strain K279a)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSMAL522373:GJE8-3461-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:Smlt3579
OrganismiStenotrophomonas maltophilia (strain K279a)
Taxonomic identifieri522373 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeStenotrophomonasStenotrophomonas maltophilia group
ProteomesiUP000008840: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 955955Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_1000132460Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei702 – 7021N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi522373.Smlt3579.

Structurei

3D structure databases

ProteinModelPortaliB2FQE7.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiERRDICL.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

B2FQE7-1 [UniParc]FASTAAdd to Basket

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MSQNTPSLRE LEHHNAFVER HIGPNDAEIA QMLDVVGHAS LDAMTDAIVP    50
AKIKSPAPLA LPESMTEVQA LAKIRAIADK NTVLRSFIGQ GYYGTHTPNV 100
ILRNILENPA WYTAYTPYQA EISQGRMEAL INFQTLCADL TGMEIANASL 150
LDEATAAAEA MTLAKRSAKS KSDTFFVHDA VHPQTLELLR TRAEPMGIVL 200
RVGTPAEALE AEAFGLLLQY PDTFGQVGDY KALVDAVHAR GGLVAVATDL 250
LALTLLAAPG EWGADIVVGN SQRFGVPFGF GGPHAAFMAC RDAYKRSMPG 300
RLIGVSIDAQ GNPAYRLTLQ TREQHIRREK ATSNICTAQV LLAVMASMYA 350
VYHGPEGLTR IARRTHRLAS ILAAALRNAG VQVGGDFFDT LHVTGVHADE 400
IHAKARAAGY NLRAIDSDSV GISLDETTTR ADIVAVAAVF GASLDVDALD 450
ASTADALPAG LLRQSAFLTH PVFNTHHSEH ELLRYLRSLA DKDLAMDRTM 500
IPLGSCTMKL NATAEMIPVT WPEFSQIHPL VPADQALGYK ELIDTLEAML 550
VECTGYDAVS LQPNSGAQGE YAGLLAIRAY HRSRGEGHRD ICLIPDSAHG 600
TNPASAQMCG MKVVVTKTDA NGNVDVEDIR LNAEKYSDRL AAIMMTYPST 650
HGVFEEEVVE ICEIIHKHGG QVYTDGANMN ALVGVAKPGK WGSDVSHLNL 700
HKTFCIPHGG GGPGVGPCAV KEHLAPFLPG KLGDNGPVGM VSAASFGSAS 750
ILPISWMYIA MMGREGLRKA TQVAQLNANY IAKRLAPHFK TLYTGRNGLV 800
AHECILDVRP LEKTSGIGAE DVAKRLIDFG FHAPTLSFPV AGTLMVEPTE 850
SESLHELDRF IDAMIQIREE ITAIEDGRLD REDNPLKNAP HTATAVTASE 900
WTHAYPRELA AFPLASLKQS KYWPPVARVD NVYGDKNVMC ACIPVDAYKD 950
DEVEA 955
Length:955
Mass (Da):102,998
Last modified:June 10, 2008 - v1
Checksum:i9AF7C403FAA3C8FC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM743169 Genomic DNA. Translation: CAQ46996.1.
RefSeqiWP_005414179.1. NC_010943.1.
YP_001973285.1. NC_010943.1.

Genome annotation databases

EnsemblBacteriaiCAQ46996; CAQ46996; Smlt3579.
GeneIDi6394970.
KEGGisml:Smlt3579.
PATRICi23702617. VBISteMal45202_3361.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM743169 Genomic DNA. Translation: CAQ46996.1 .
RefSeqi WP_005414179.1. NC_010943.1.
YP_001973285.1. NC_010943.1.

3D structure databases

ProteinModelPortali B2FQE7.
ModBasei Search...

Protein-protein interaction databases

STRINGi 522373.Smlt3579.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAQ46996 ; CAQ46996 ; Smlt3579 .
GeneIDi 6394970.
KEGGi sml:Smlt3579.
PATRICi 23702617. VBISteMal45202_3361.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi ERRDICL.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci SMAL522373:GJE8-3461-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome, comparative and functional analysis of Stenotrophomonas maltophilia reveals an organism heavily shielded by drug resistance determinants."
    Crossman L.C., Gould V.C., Dow J.M., Vernikos G.S., Okazaki A., Sebaihia M., Saunders D., Arrowsmith C., Carver T., Peters N., Adlem E., Kerhornou A., Lord A., Murphy L., Seeger K., Squares R., Rutter S., Quail M.A.
    , Rajandream M.A., Harris D., Churcher C., Bentley S.D., Parkhill J., Thomson N.R., Avison M.B.
    Genome Biol. 9:R74.1-R74.13(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K279a.

Entry informationi

Entry nameiGCSP_STRMK
AccessioniPrimary (citable) accession number: B2FQE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: September 3, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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