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B2FQ90 (BETB_STRMK) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Betaine aldehyde dehydrogenase
Short name=BADH
EC=1.2.1.8
Gene names
Name:betB
Ordered Locus Names:Smlt2238
OrganismStenotrophomonas maltophilia (strain K279a) [Complete proteome] [HAMAP]
Taxonomic identifier522373 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Stenotrophomonas › Stenotrophomonas maltophilia group ›

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP-Rule MF_00804

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP-Rule MF_00804

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycine betaine biosynthetic process from choline

Inferred from electronic annotation. Source: HAMAP

   Molecular_functionbetaine-aldehyde dehydrogenase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 490490Betaine aldehyde dehydrogenase HAMAP-Rule MF_00804
PRO_1000133960

Regions

Nucleotide binding229 – 2346NAD By similarity

Sites

Active site2521 By similarity
Active site2861 By similarity

Sequences

Sequence LengthMass (Da)Tools
B2FQ90 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: 01F6010F8CDC9EB0

FASTA49052,665
        10         20         30         40         50         60 
MTTLPVQQLY IHGQRVDATS GKTFKTVNPA TGEVIAEVQV ASQADVERAV QSASEGQKVW 

        70         80         90        100        110        120 
AAMTAMERSR ILRRAVEILR ERNDELAHLE TLDTGKALAE TTTVDIVTGA DVVEYYAGLA 

       130        140        150        160        170        180 
TAIEGIQLPL RESSFFYTRR EPLGVVAGIG AWNYPIQIAM WKSAPALAAG NAMVFKPSEV 

       190        200        210        220        230        240 
TPLTAIRLAE IYTEAGVPAG VFNVVQGPGR EIGQWLTEHP VIEKISFTGG VATGKKVMAS 

       250        260        270        280        290        300 
AASSSLKEVT MELGGKSPLV ICDDADLDRA ADIAVMANFF SSGQVCTNGT RVFVPRSMLA 

       310        320        330        340        350        360 
AFEAAVVERV KRIRIGDPMA AETNFGPLTS FPHMENVLRY IESGKAEGAR LLTGGGRATE 

       370        380        390        400        410        420 
GALANGAYVL PTVFSDCRDD MTIVKEEIFG PVMSILAYDD EDEVVRRAND TTFGLAAGVV 

       430        440        450        460        470        480 
SKDISRAHRI IHRLEAGICW INTWGESPAE MPVGGYKESG VGRENGISTL GHYTRIKSVQ 

       490 
VELGDYASVF

« Hide

References

[1]"The complete genome, comparative and functional analysis of Stenotrophomonas maltophilia reveals an organism heavily shielded by drug resistance determinants."
Crossman L.C., Gould V.C., Dow J.M., Vernikos G.S., Okazaki A., Sebaihia M., Saunders D., Arrowsmith C., Carver T., Peters N., Adlem E., Kerhornou A., Lord A., Murphy L., Seeger K., Squares R., Rutter S., Quail M.A. expand/collapse author list , Rajandream M.A., Harris D., Churcher C., Bentley S.D., Parkhill J., Thomson N.R., Avison M.B.
Genome Biol. 9:R74.1-R74.13(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K279a.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM743169 Genomic DNA. Translation: CAQ45735.1.
RefSeqYP_001972035.1. NC_010943.1.

3D structure databases

ProteinModelPortalB2FQ90.
ModBaseSearch...

Protein-protein interaction databases

STRING522373.Smlt2238.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAQ45735; CAQ45735; Smlt2238.
GeneID6394285.
KEGGsml:Smlt2238.
PATRIC23700125. VBISteMal45202_2132.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHOG000271505.
KOK00130.
OMAFSDCRDD.
ProtClustDBPRK13252.

Enzyme and pathway databases

BioCycSMAL522373:GJE8-2176-MONOMER.
UniPathwayUPA00529; UER00386.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPMF_00804. BADH.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. Betaine_Ald_DH.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR01804. BADH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETB_STRMK
AccessionPrimary (citable) accession number: B2FQ90
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: May 1, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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