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B2FQ89 (BETA_STRMK) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Oxygen-dependent choline dehydrogenase

Short name=CDH
Short name=CHD
EC=1.1.99.1
Alternative name(s):
Betaine aldehyde dehydrogenase
Short name=BADH
EC=1.2.1.8
Gene names
Name:betA
Ordered Locus Names:Smlt2237
OrganismStenotrophomonas maltophilia (strain K279a) [Complete proteome] [HAMAP]
Taxonomic identifier522373 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeStenotrophomonasStenotrophomonas maltophilia group

Protein attributes

Sequence length560 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate By similarity. HAMAP-Rule MF_00750

Catalytic activity

Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP-Rule MF_00750

Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP-Rule MF_00750

Cofactor

FAD By similarity. HAMAP-Rule MF_00750

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP-Rule MF_00750

Sequence similarities

Belongs to the GMC oxidoreductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 560560Oxygen-dependent choline dehydrogenase HAMAP-Rule MF_00750
PRO_1000133339

Regions

Nucleotide binding8 – 3730FAD By similarity

Sites

Active site4751 By similarity

Sequences

Sequence LengthMass (Da)Tools
B2FQ89 [UniParc].

Last modified June 10, 2008. Version 1.
Checksum: E433E13CD786AF16

FASTA56061,800
        10         20         30         40         50         60 
MSTHNEYDYI IIGAGSAGNV LATRLTEDAD VSVLLLEAGG PDYRLDFRTQ MPAALAFPLQ 

        70         80         90        100        110        120 
GKRYNWAYKT DPEPFMNNRR MDCGRGKGLG GSSLINGMCY IRGNAMDYDN WASMPGLEDW 

       130        140        150        160        170        180 
TYLDCLPYFR KAETRDIGPN DYHGGDGPLR VTTPKAGNNE LFAAMVEAGV QAGYPRTDDL 

       190        200        210        220        230        240 
NGYQQEGFGP MDRTVTPKGR RSSTARGYLD LAKPRPNLTI VTHALTDRIL FSGKRAVGVQ 

       250        260        270        280        290        300 
WLRNDQPQRA TARREVLLCG GAIASPQILQ RSGVGPADLL RSLDIDLVHH LPGVGANLQD 

       310        320        330        340        350        360 
HLEMYLQYEC KKPVSLAPAL KLYNQPAIGA EWLFLGTGIG ASNQFEAGGF IRSDAEFDWP 

       370        380        390        400        410        420 
NLQYHFLPVA INYNGSNPIK AHSFQMHVGS MRSPSRGRIH VRSKDPREHP SILFNYMSHE 

       430        440        450        460        470        480 
QDWREFRAAI RITREIFAQP ALAPYSGREI SPGSALQTDA QIDAFVREHA ETAYHPSCSN 

       490        500        510        520        530        540 
KMGHADDPMA VVDGQGRVHG LEGLRIVDAS IMPQVVTGNL NAPTIMMAEK LADVIRGRTP 

       550        560 
LARSTAPYYK ANGAPVRKQD 

« Hide

References

[1]"The complete genome, comparative and functional analysis of Stenotrophomonas maltophilia reveals an organism heavily shielded by drug resistance determinants."
Crossman L.C., Gould V.C., Dow J.M., Vernikos G.S., Okazaki A., Sebaihia M., Saunders D., Arrowsmith C., Carver T., Peters N., Adlem E., Kerhornou A., Lord A., Murphy L., Seeger K., Squares R., Rutter S., Quail M.A. expand/collapse author list , Rajandream M.A., Harris D., Churcher C., Bentley S.D., Parkhill J., Thomson N.R., Avison M.B.
Genome Biol. 9:R74.1-R74.13(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K279a.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM743169 Genomic DNA. Translation: CAQ45734.1.
RefSeqYP_001972034.1. NC_010943.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING522373.Smlt2237.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAQ45734; CAQ45734; Smlt2237.
GeneID6391476.
KEGGsml:Smlt2237.
PATRIC23700123. VBISteMal45202_2131.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2303.
HOGENOMHOG000139600.
KOK00108.
OMAYLQYACT.
OrthoDBEOG67HJQP.

Enzyme and pathway databases

BioCycSMAL522373:GJE8-2175-MONOMER.
UniPathwayUPA00529; UER00385.

Family and domain databases

HAMAPMF_00750. Choline_dehydrogen.
InterProIPR011533. Choline_dehydrogenase.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsTIGR01810. betA. 1 hit.
PROSITEPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETA_STRMK
AccessionPrimary (citable) accession number: B2FQ89
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways