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B2FQ89

- BETA_STRMK

UniProt

B2FQ89 - BETA_STRMK

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Protein

Oxygen-dependent choline dehydrogenase

Gene
betA, Smlt2237
Organism
Stenotrophomonas maltophilia (strain K279a)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate By similarity.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FAD By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei475 – 4751 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 3730FAD By similarityAdd
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciSMAL522373:GJE8-2175-MONOMER.
UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenase (EC:1.1.99.1)
Short name:
CDH
Short name:
CHD
Alternative name(s):
Betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Gene namesi
Name:betA
Ordered Locus Names:Smlt2237
OrganismiStenotrophomonas maltophilia (strain K279a)
Taxonomic identifieri522373 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeStenotrophomonasStenotrophomonas maltophilia group
ProteomesiUP000008840: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 560560Oxygen-dependent choline dehydrogenaseUniRule annotationPRO_1000133339Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi522373.Smlt2237.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiYLQYACT.
OrthoDBiEOG67HJQP.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2FQ89-1 [UniParc]FASTAAdd to Basket

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MSTHNEYDYI IIGAGSAGNV LATRLTEDAD VSVLLLEAGG PDYRLDFRTQ    50
MPAALAFPLQ GKRYNWAYKT DPEPFMNNRR MDCGRGKGLG GSSLINGMCY 100
IRGNAMDYDN WASMPGLEDW TYLDCLPYFR KAETRDIGPN DYHGGDGPLR 150
VTTPKAGNNE LFAAMVEAGV QAGYPRTDDL NGYQQEGFGP MDRTVTPKGR 200
RSSTARGYLD LAKPRPNLTI VTHALTDRIL FSGKRAVGVQ WLRNDQPQRA 250
TARREVLLCG GAIASPQILQ RSGVGPADLL RSLDIDLVHH LPGVGANLQD 300
HLEMYLQYEC KKPVSLAPAL KLYNQPAIGA EWLFLGTGIG ASNQFEAGGF 350
IRSDAEFDWP NLQYHFLPVA INYNGSNPIK AHSFQMHVGS MRSPSRGRIH 400
VRSKDPREHP SILFNYMSHE QDWREFRAAI RITREIFAQP ALAPYSGREI 450
SPGSALQTDA QIDAFVREHA ETAYHPSCSN KMGHADDPMA VVDGQGRVHG 500
LEGLRIVDAS IMPQVVTGNL NAPTIMMAEK LADVIRGRTP LARSTAPYYK 550
ANGAPVRKQD 560
Length:560
Mass (Da):61,800
Last modified:June 10, 2008 - v1
Checksum:iE433E13CD786AF16
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM743169 Genomic DNA. Translation: CAQ45734.1.
RefSeqiYP_001972034.1. NC_010943.1.

Genome annotation databases

EnsemblBacteriaiCAQ45734; CAQ45734; Smlt2237.
GeneIDi6391476.
KEGGisml:Smlt2237.
PATRICi23700123. VBISteMal45202_2131.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM743169 Genomic DNA. Translation: CAQ45734.1 .
RefSeqi YP_001972034.1. NC_010943.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 522373.Smlt2237.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAQ45734 ; CAQ45734 ; Smlt2237 .
GeneIDi 6391476.
KEGGi sml:Smlt2237.
PATRICi 23700123. VBISteMal45202_2131.

Phylogenomic databases

eggNOGi COG2303.
HOGENOMi HOG000139600.
KOi K00108.
OMAi YLQYACT.
OrthoDBi EOG67HJQP.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00385 .
BioCyci SMAL522373:GJE8-2175-MONOMER.

Family and domain databases

HAMAPi MF_00750. Choline_dehydrogen.
InterProi IPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view ]
Pfami PF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsi TIGR01810. betA. 1 hit.
PROSITEi PS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome, comparative and functional analysis of Stenotrophomonas maltophilia reveals an organism heavily shielded by drug resistance determinants."
    Crossman L.C., Gould V.C., Dow J.M., Vernikos G.S., Okazaki A., Sebaihia M., Saunders D., Arrowsmith C., Carver T., Peters N., Adlem E., Kerhornou A., Lord A., Murphy L., Seeger K., Squares R., Rutter S., Quail M.A.
    , Rajandream M.A., Harris D., Churcher C., Bentley S.D., Parkhill J., Thomson N.R., Avison M.B.
    Genome Biol. 9:R74.1-R74.13(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K279a.

Entry informationi

Entry nameiBETA_STRMK
AccessioniPrimary (citable) accession number: B2FQ89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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