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B2FQ70

- DAPB_STRMK

UniProt

B2FQ70 - DAPB_STRMK

Protein

4-hydroxy-tetrahydrodipicolinate reductase

Gene

dapB

Organism
Stenotrophomonas maltophilia (strain K279a)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (10 Jun 2008)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.UniRule annotation

    Catalytic activityi

    (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei150 – 1501Proton donor/acceptorUniRule annotation
    Binding sitei151 – 1511SubstrateUniRule annotation
    Active sitei154 – 1541Proton donorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 176NAD(P)UniRule annotation
    Nucleotide bindingi94 – 963NAD(P)UniRule annotation
    Nucleotide bindingi118 – 1214NAD(P)UniRule annotation

    GO - Molecular functioni

    1. 4-hydroxy-tetrahydrodipicolinate reductase Source: UniProtKB-EC
    2. NAD binding Source: UniProtKB-HAMAP
    3. NADPH binding Source: InterPro
    4. oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor Source: UniProtKB-HAMAP

    GO - Biological processi

    1. diaminopimelate biosynthetic process Source: UniProtKB-HAMAP
    2. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Diaminopimelate biosynthesis, Lysine biosynthesis

    Keywords - Ligandi

    NAD, NADP

    Enzyme and pathway databases

    BioCyciSMAL522373:GJE8-2156-MONOMER.
    UniPathwayiUPA00034; UER00018.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4-hydroxy-tetrahydrodipicolinate reductaseUniRule annotation (EC:1.17.1.8UniRule annotation)
    Short name:
    HTPA reductaseUniRule annotation
    Gene namesi
    Name:dapBUniRule annotation
    Ordered Locus Names:Smlt2217
    OrganismiStenotrophomonas maltophilia (strain K279a)
    Taxonomic identifieri522373 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeStenotrophomonasStenotrophomonas maltophilia group
    ProteomesiUP000008840: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2392394-hydroxy-tetrahydrodipicolinate reductasePRO_1000094011Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi522373.Smlt2217.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni160 – 1612Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the DapB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0289.
    HOGENOMiHOG000227153.
    KOiK00215.
    OMAiQPRYVSL.
    OrthoDBiEOG6SV5DS.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00102. DapB.
    InterProiIPR022663. DapB_C.
    IPR000846. DapB_N.
    IPR022664. DapB_N_CS.
    IPR011770. Dihydrodipicolinate_Rdtase.
    IPR023940. Dihydrodipicolinate_Rdtase_bac.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR20836. PTHR20836. 1 hit.
    PfamiPF05173. DapB_C. 1 hit.
    PF01113. DapB_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000161. DHPR. 1 hit.
    TIGRFAMsiTIGR00036. dapB. 1 hit.
    PROSITEiPS01298. DAPB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2FQ70-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNQTPLRLLI HGASGRMGQA LLRLAAEHPE TLQIAAAVTG RAPAQRVVDG    50
    VPFFAASELP GAPAFDVAID FSLPEGFDPM LALCVERGAG LVSGTTGISS 100
    TQRQALEAAA ARIPLVWASN FSLGVAVLDE LVERAAQALA GWDCDIVESH 150
    HTQKKDAPSG TALTLGAAAQ RGGAEPHYAS LRAGDIVGEH LVQFTGLGER 200
    IELVHRATNR DIFARGALFA ARQLQGRAPG SYRVRDLLQ 239
    Length:239
    Mass (Da):25,157
    Last modified:June 10, 2008 - v1
    Checksum:i4287EC0BB102D83B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM743169 Genomic DNA. Translation: CAQ45715.1.
    RefSeqiYP_001972016.1. NC_010943.1.

    Genome annotation databases

    EnsemblBacteriaiCAQ45715; CAQ45715; Smlt2217.
    GeneIDi6394132.
    KEGGisml:Smlt2217.
    PATRICi23700081. VBISteMal45202_2110.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM743169 Genomic DNA. Translation: CAQ45715.1 .
    RefSeqi YP_001972016.1. NC_010943.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 522373.Smlt2217.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAQ45715 ; CAQ45715 ; Smlt2217 .
    GeneIDi 6394132.
    KEGGi sml:Smlt2217.
    PATRICi 23700081. VBISteMal45202_2110.

    Phylogenomic databases

    eggNOGi COG0289.
    HOGENOMi HOG000227153.
    KOi K00215.
    OMAi QPRYVSL.
    OrthoDBi EOG6SV5DS.

    Enzyme and pathway databases

    UniPathwayi UPA00034 ; UER00018 .
    BioCyci SMAL522373:GJE8-2156-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00102. DapB.
    InterProi IPR022663. DapB_C.
    IPR000846. DapB_N.
    IPR022664. DapB_N_CS.
    IPR011770. Dihydrodipicolinate_Rdtase.
    IPR023940. Dihydrodipicolinate_Rdtase_bac.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR20836. PTHR20836. 1 hit.
    Pfami PF05173. DapB_C. 1 hit.
    PF01113. DapB_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000161. DHPR. 1 hit.
    TIGRFAMsi TIGR00036. dapB. 1 hit.
    PROSITEi PS01298. DAPB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome, comparative and functional analysis of Stenotrophomonas maltophilia reveals an organism heavily shielded by drug resistance determinants."
      Crossman L.C., Gould V.C., Dow J.M., Vernikos G.S., Okazaki A., Sebaihia M., Saunders D., Arrowsmith C., Carver T., Peters N., Adlem E., Kerhornou A., Lord A., Murphy L., Seeger K., Squares R., Rutter S., Quail M.A.
      , Rajandream M.A., Harris D., Churcher C., Bentley S.D., Parkhill J., Thomson N.R., Avison M.B.
      Genome Biol. 9:R74.1-R74.13(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K279a.

    Entry informationi

    Entry nameiDAPB_STRMK
    AccessioniPrimary (citable) accession number: B2FQ70
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Caution

    Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3