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B2FPR7

- SYL_STRMK

UniProt

B2FPR7 - SYL_STRMK

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Protein
Leucine--tRNA ligase
Gene
leuS, Smlt3485
Organism
Stenotrophomonas maltophilia (strain K279a)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei641 – 6411ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSMAL522373:GJE8-3373-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Smlt3485
OrganismiStenotrophomonas maltophilia (strain K279a)
Taxonomic identifieri522373 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeStenotrophomonasStenotrophomonas maltophilia group
ProteomesiUP000008840: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 880880Leucine--tRNA ligaseUniRule annotation
PRO_1000091368Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi522373.Smlt3485.

Structurei

3D structure databases

ProteinModelPortaliB2FPR7.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi46 – 5611"HIGH" regionUniRule annotation
Add
BLAST
Motifi638 – 6425"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiMAFAGPP.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2FPR7-1 [UniParc]FASTAAdd to Basket

« Hide

MTSAETNAYD PQQVESAAQK YWDATRAFEV DETSDKPKYY CLSMLPYPSG    50
ALHMGHVRNY TIGDVISRYK RMTGHNVLQP MGWDAFGLPA ENAAIKNKTA 100
PAAWTYKNIE HMRGQFKAMG YAVDWSREFA TCRPDYYVHE QRMFTRLMRK 150
GLAYRRNAVV NWDPVDQTVL ANEQVIDGRG WRSGALVEKR EIPQWFLRIT 200
DYAQELLDGL DELDGWPDSV KTMQRNWIGR SEGLEIQFDV RDVDGTALDP 250
LRVFTTRPDT VMGVTFVSIA AEHPLALHAA KNNPELAALL SEMKQGGVSE 300
AELETQEKRG MDTGLRAIHP VTGEKVPVWV ANFVLMGYGT GAVMAVPGHD 350
QRDNEVANKY GLPIKQVIAL KDPRNDDERT WDGARWQDWY SDKNRAFELV 400
NSAEFDGLDF QGAFEALAER FERKAQGQRR VNYRLRDWGV SRQRYWGCPI 450
PVIYCDKCGA VPVPEEQLPV VLPEDVAFSG TGSPIKTDPE WRKTTCPECG 500
GAAERETDTF DTFMESSWYY ARYTSPGARD AVDKRGNYWL PVDQYIGGIE 550
HAILHLMYFR FYHKLLRDAR MVDSNEPARN LLCQGMVIAE TYYRPNPDGS 600
KDWINPADVE VQRDERGRIT GATLIADGQP VVVGGTEKMS KSKNNGVDPQ 650
AMVDKYGADT VRLFSMFAAP PEQSLEWNEA GVDGMARFLR RLWAQVQKHA 700
ADGAAPALDV AALDANQKAL RRKTHETIGK VGDDYGRRHS FNTAIAAVME 750
LMNALAKFED GSEQGRAVRQ EALQAIVLLL NPITPHASHA LWQVLGHGET 800
LLEDQPFPQA DAGALVRDAL TLAVQVNGKL RGTIEVAADA AREQVEALAL 850
AEPNAAKFME GLTVRKIIIV PGKIVNIVAA 880
Length:880
Mass (Da):98,446
Last modified:June 10, 2008 - v1
Checksum:iF27102B3E388C6A6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM743169 Genomic DNA. Translation: CAQ46908.1.
RefSeqiYP_001973197.1. NC_010943.1.

Genome annotation databases

EnsemblBacteriaiCAQ46908; CAQ46908; Smlt3485.
GeneIDi6394000.
KEGGisml:Smlt3485.
PATRICi23702433. VBISteMal45202_3269.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM743169 Genomic DNA. Translation: CAQ46908.1 .
RefSeqi YP_001973197.1. NC_010943.1.

3D structure databases

ProteinModelPortali B2FPR7.
ModBasei Search...

Protein-protein interaction databases

STRINGi 522373.Smlt3485.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAQ46908 ; CAQ46908 ; Smlt3485 .
GeneIDi 6394000.
KEGGi sml:Smlt3485.
PATRICi 23702433. VBISteMal45202_3269.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi MAFAGPP.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SMAL522373:GJE8-3373-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome, comparative and functional analysis of Stenotrophomonas maltophilia reveals an organism heavily shielded by drug resistance determinants."
    Crossman L.C., Gould V.C., Dow J.M., Vernikos G.S., Okazaki A., Sebaihia M., Saunders D., Arrowsmith C., Carver T., Peters N., Adlem E., Kerhornou A., Lord A., Murphy L., Seeger K., Squares R., Rutter S., Quail M.A.
    , Rajandream M.A., Harris D., Churcher C., Bentley S.D., Parkhill J., Thomson N.R., Avison M.B.
    Genome Biol. 9:R74.1-R74.13(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K279a.

Entry informationi

Entry nameiSYL_STRMK
AccessioniPrimary (citable) accession number: B2FPR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: June 10, 2008
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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