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B2FPR7

- SYL_STRMK

UniProt

B2FPR7 - SYL_STRMK

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Stenotrophomonas maltophilia (strain K279a)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei641 – 6411ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSMAL522373:GJE8-3373-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Smlt3485
OrganismiStenotrophomonas maltophilia (strain K279a)
Taxonomic identifieri522373 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeStenotrophomonasStenotrophomonas maltophilia group
ProteomesiUP000008840: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 880880Leucine--tRNA ligasePRO_1000091368Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi522373.Smlt3485.

Structurei

3D structure databases

ProteinModelPortaliB2FPR7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi46 – 5611"HIGH" regionAdd
BLAST
Motifi638 – 6425"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiMAFAGPP.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2FPR7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSAETNAYD PQQVESAAQK YWDATRAFEV DETSDKPKYY CLSMLPYPSG
60 70 80 90 100
ALHMGHVRNY TIGDVISRYK RMTGHNVLQP MGWDAFGLPA ENAAIKNKTA
110 120 130 140 150
PAAWTYKNIE HMRGQFKAMG YAVDWSREFA TCRPDYYVHE QRMFTRLMRK
160 170 180 190 200
GLAYRRNAVV NWDPVDQTVL ANEQVIDGRG WRSGALVEKR EIPQWFLRIT
210 220 230 240 250
DYAQELLDGL DELDGWPDSV KTMQRNWIGR SEGLEIQFDV RDVDGTALDP
260 270 280 290 300
LRVFTTRPDT VMGVTFVSIA AEHPLALHAA KNNPELAALL SEMKQGGVSE
310 320 330 340 350
AELETQEKRG MDTGLRAIHP VTGEKVPVWV ANFVLMGYGT GAVMAVPGHD
360 370 380 390 400
QRDNEVANKY GLPIKQVIAL KDPRNDDERT WDGARWQDWY SDKNRAFELV
410 420 430 440 450
NSAEFDGLDF QGAFEALAER FERKAQGQRR VNYRLRDWGV SRQRYWGCPI
460 470 480 490 500
PVIYCDKCGA VPVPEEQLPV VLPEDVAFSG TGSPIKTDPE WRKTTCPECG
510 520 530 540 550
GAAERETDTF DTFMESSWYY ARYTSPGARD AVDKRGNYWL PVDQYIGGIE
560 570 580 590 600
HAILHLMYFR FYHKLLRDAR MVDSNEPARN LLCQGMVIAE TYYRPNPDGS
610 620 630 640 650
KDWINPADVE VQRDERGRIT GATLIADGQP VVVGGTEKMS KSKNNGVDPQ
660 670 680 690 700
AMVDKYGADT VRLFSMFAAP PEQSLEWNEA GVDGMARFLR RLWAQVQKHA
710 720 730 740 750
ADGAAPALDV AALDANQKAL RRKTHETIGK VGDDYGRRHS FNTAIAAVME
760 770 780 790 800
LMNALAKFED GSEQGRAVRQ EALQAIVLLL NPITPHASHA LWQVLGHGET
810 820 830 840 850
LLEDQPFPQA DAGALVRDAL TLAVQVNGKL RGTIEVAADA AREQVEALAL
860 870 880
AEPNAAKFME GLTVRKIIIV PGKIVNIVAA
Length:880
Mass (Da):98,446
Last modified:June 10, 2008 - v1
Checksum:iF27102B3E388C6A6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM743169 Genomic DNA. Translation: CAQ46908.1.
RefSeqiWP_012480931.1. NC_010943.1.
YP_001973197.1. NC_010943.1.

Genome annotation databases

EnsemblBacteriaiCAQ46908; CAQ46908; Smlt3485.
GeneIDi6394000.
KEGGisml:Smlt3485.
PATRICi23702433. VBISteMal45202_3269.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM743169 Genomic DNA. Translation: CAQ46908.1 .
RefSeqi WP_012480931.1. NC_010943.1.
YP_001973197.1. NC_010943.1.

3D structure databases

ProteinModelPortali B2FPR7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 522373.Smlt3485.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAQ46908 ; CAQ46908 ; Smlt3485 .
GeneIDi 6394000.
KEGGi sml:Smlt3485.
PATRICi 23702433. VBISteMal45202_3269.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi MAFAGPP.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SMAL522373:GJE8-3373-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome, comparative and functional analysis of Stenotrophomonas maltophilia reveals an organism heavily shielded by drug resistance determinants."
    Crossman L.C., Gould V.C., Dow J.M., Vernikos G.S., Okazaki A., Sebaihia M., Saunders D., Arrowsmith C., Carver T., Peters N., Adlem E., Kerhornou A., Lord A., Murphy L., Seeger K., Squares R., Rutter S., Quail M.A.
    , Rajandream M.A., Harris D., Churcher C., Bentley S.D., Parkhill J., Thomson N.R., Avison M.B.
    Genome Biol. 9:R74.1-R74.13(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K279a.

Entry informationi

Entry nameiSYL_STRMK
AccessioniPrimary (citable) accession number: B2FPR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: June 10, 2008
Last modified: October 29, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3