Reviewed, UniProtKB/Swiss-Prot B2FL98 (KMO_STRMK)

Names and origin

Protein names

Recommended name:
    Kynurenine 3-monooxygenase
    EC=1.14.13.9
Alternative name(s):
    Kynurenine 3-hydroxylase

Gene names

Name:	kmo
Ordered Locus Names:	Smlt3161

Organism

Stenotrophomonas maltophilia (strain K279a) [Complete proteome] [HAMAP]

Taxonomic identifier

522373 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Stenotrophomonas

Protein attributes

Sequence length	455 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid By similarity.
Catalytic activity	L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O.
Cofactor	FAD By similarity.
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.
Sequence similarities	Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Ligand	FAD Flavoprotein NADP
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pyridine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	kynurenine 3-monooxygenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 455	455	Kynurenine 3-monooxygenase		PRO_0000361945

Sequences

	Sequence		Length	Mass (Da)
	B2FL98-1 [UniParc]. Last modified June 10, 2008. Version 1. Checksum: 692D6D46C223FDDB	FASTA	455	51,074
	10 20 30 40 50 60 MIAHASRSLS IIGAGLAGSL LAILLSRQGW RITLYERRGD PRVADYESGR SINLALAERG 70 80 90 100 110 120 RNALRQAGVE DEVMARAVMM RGRMVHPREG EPQLQRYGRD DSEVIWSIHR SDLNTTLLEL 130 140 150 160 170 180 AEQAGATVHF HRRLHTVDFD AGYARFIDDR DDSPHDIRFD TLIGADGAGS ALRAAMNRRA 190 200 210 220 230 240 PLGEDIAFLD HSYKELEIPP ADDGSFRIER NALHIWPRGH YMCIALPNHE GTFTVTLFLP 250 260 270 280 290 300 NQGDPSFATI NTGAQAEALF AREFADTLPL IPNLRADWEQ HPPGLLGTLT LDRWHQQGRA 310 320 330 340 350 360 VLIGDAAHAM VPFHGQGMNC AFEDCVALAR HLMEADDLEG AFAAFEAERK PNARAIQQMA 370 380 390 400 410 420 LENYLEMRDR VADPAFLLQR ELEQELQRRW PTRFVPHYTM VTFLHTPYAE ALRRTELQRD 430 440 450 MLVAATTGHD SLDNIDWAAL EAQIHAQLPV LEGAH

References

[1]

"The complete genome, comparative and functional analysis of Stenotrophomonas maltophilia reveals an organism heavily shielded by drug resistance determinants." Crossman L.C., Gould V.C., Dow J.M., Vernikos G.S., Okazaki A., Sebaihia M., Saunders D., Arrowsmith C., Carver T., Peters N., Adlem E., Kerhornou A., Lord A., Murphy L., Seeger K., Squares R., Rutter S., Quail M.A. , Rajandream M.A., Harris D., Churcher C., Bentley S.D., Parkhill J., Thomson N.R., Avison M.B. Genome Biol. 9:RESEARCH074.1-RESEARCH074.13(2008) [PubMed: 18419807] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM743169 Genomic DNA. Translation: CAQ46605.1.
RefSeq	YP_001972896.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6394111.
GenomeReviews	Gene locus Smlt3161 in contig AM743169_GR.
KEGG	sml:Smlt3161.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	LHAIMPS.
Family and domain databases
InterPro	IPR002938. mOase_FAD_bd. IPR003042. Rng_hydrolase-like. [Graphical view]
Pfam	PF01494. FAD_binding_3. 1 hit. [Graphical view]
PRINTS	PR00420. RNGMNOXGNASE.
ProtoNet	Search...

Entry information

Entry name

KMO_STRMK

Accession

Primary (citable) accession number: B2FL98

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	June 10, 2008
Last modified:	November 3, 2009
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)