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B2FHN6

- LPXA_STRMK

UniProt

B2FHN6 - LPXA_STRMK

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Protein

Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene

lpxA

Organism
Stenotrophomonas maltophilia (strain K279a)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

(R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetyl-alpha-D-glucosamine = [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetyl-alpha-D-glucosamine.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciSMAL522373:GJE8-1451-MONOMER.
UniPathwayiUPA00359; UER00477.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferaseUniRule annotation (EC:2.3.1.129UniRule annotation)
Short name:
UDP-N-acetylglucosamine acyltransferaseUniRule annotation
Gene namesi
Name:lpxAUniRule annotation
Ordered Locus Names:Smlt1495
OrganismiStenotrophomonas maltophilia (strain K279a)
Taxonomic identifieri522373 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeStenotrophomonasStenotrophomonas maltophilia group
ProteomesiUP000008840: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 263263Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferasePRO_1000122736Add
BLAST

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi522373.Smlt1495.

Structurei

3D structure databases

ProteinModelPortaliB2FHN6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transferase hexapeptide repeat family. LpxA subfamily.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1043.
HOGENOMiHOG000294326.
KOiK00677.
OMAiDCQDKKY.
OrthoDBiEOG6F81P1.

Family and domain databases

Gene3Di1.20.1180.10. 1 hit.
HAMAPiMF_00387. LpxA.
InterProiIPR029098. Acetyltransf_C.
IPR001451. Hexapep_transf.
IPR010137. Lipid_A_LpxA.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PfamiPF13720. Acetyltransf_11. 1 hit.
PF00132. Hexapep. 3 hits.
[Graphical view]
PIRSFiPIRSF000456. UDP-GlcNAc_acltr. 1 hit.
SUPFAMiSSF51161. SSF51161. 1 hit.
TIGRFAMsiTIGR01852. lipid_A_lpxA. 1 hit.

Sequencei

Sequence statusi: Complete.

B2FHN6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDNAPRIHP TAVIDPAARL ADDVQVGAFT LIGADVEIGA GTVVGPHCSI
60 70 80 90 100
HGPTRIGRDN RFIGHAAIGG EPQDKKFAGE RTELVIGDRN VFREFVTLNR
110 120 130 140 150
GTGGGGGITT IGNDNWMLAY THVAHDCHVG NFCVFSNNTT LAGHVTVGDY
160 170 180 190 200
VIISGFAGAH QFCRIGAHAF LGMGALTNGD VPPFTMVGTD SLGRPRGINS
210 220 230 240 250
EGLKRRGFDA ERISAIKRAY RTLYVAGLPL AEAKVQLTEQ ARDSDDVKAM
260
LDFIEHAERP LLR
Length:263
Mass (Da):28,100
Last modified:June 10, 2008 - v1
Checksum:iEEBAFE43C298AF48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM743169 Genomic DNA. Translation: CAQ45031.1.
RefSeqiYP_001971336.1. NC_010943.1.

Genome annotation databases

EnsemblBacteriaiCAQ45031; CAQ45031; Smlt1495.
GeneIDi6393858.
KEGGisml:Smlt1495.
PATRICi23698687. VBISteMal45202_1432.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM743169 Genomic DNA. Translation: CAQ45031.1 .
RefSeqi YP_001971336.1. NC_010943.1.

3D structure databases

ProteinModelPortali B2FHN6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 522373.Smlt1495.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAQ45031 ; CAQ45031 ; Smlt1495 .
GeneIDi 6393858.
KEGGi sml:Smlt1495.
PATRICi 23698687. VBISteMal45202_1432.

Phylogenomic databases

eggNOGi COG1043.
HOGENOMi HOG000294326.
KOi K00677.
OMAi DCQDKKY.
OrthoDBi EOG6F81P1.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00477 .
BioCyci SMAL522373:GJE8-1451-MONOMER.

Family and domain databases

Gene3Di 1.20.1180.10. 1 hit.
HAMAPi MF_00387. LpxA.
InterProi IPR029098. Acetyltransf_C.
IPR001451. Hexapep_transf.
IPR010137. Lipid_A_LpxA.
IPR011004. Trimer_LpxA-like.
[Graphical view ]
Pfami PF13720. Acetyltransf_11. 1 hit.
PF00132. Hexapep. 3 hits.
[Graphical view ]
PIRSFi PIRSF000456. UDP-GlcNAc_acltr. 1 hit.
SUPFAMi SSF51161. SSF51161. 1 hit.
TIGRFAMsi TIGR01852. lipid_A_lpxA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome, comparative and functional analysis of Stenotrophomonas maltophilia reveals an organism heavily shielded by drug resistance determinants."
    Crossman L.C., Gould V.C., Dow J.M., Vernikos G.S., Okazaki A., Sebaihia M., Saunders D., Arrowsmith C., Carver T., Peters N., Adlem E., Kerhornou A., Lord A., Murphy L., Seeger K., Squares R., Rutter S., Quail M.A.
    , Rajandream M.A., Harris D., Churcher C., Bentley S.D., Parkhill J., Thomson N.R., Avison M.B.
    Genome Biol. 9:R74.1-R74.13(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K279a.

Entry informationi

Entry nameiLPXA_STRMK
AccessioniPrimary (citable) accession number: B2FHN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: October 29, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3