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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Stenotrophomonas maltophilia (strain K279a)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei240ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSMAL522373:G1GK1-2416-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:Smlt1441
OrganismiStenotrophomonas maltophilia (strain K279a)
Taxonomic identifieri522373 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeStenotrophomonasStenotrophomonas maltophilia group
Proteomesi
  • UP000008840 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000901111 – 467Glutamate--tRNA ligaseAdd BLAST467

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi522373.Smlt1441

Structurei

3D structure databases

ProteinModelPortaliB2FHI7
SMRiB2FHI7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi9 – 19"HIGH" regionUniRule annotationAdd BLAST11
Motifi237 – 241"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252722
KOiK01885
OMAiHYINTLP

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

B2FHI7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTCRTRFAPS PTGYLHIGGA RTALYCWLEA RHRGGEFVLR IEDTDRERST
60 70 80 90 100
QGAIDAILEA MEWLGLDYDE GPIYQTDRVA RYLEVAEQLV ADGKAYYAYE
110 120 130 140 150
TREELDAMRE AAMARQEKPR YNGAARDLGL PRRDDPNRVI RFKNPLEGTV
160 170 180 190 200
VFDDLIKGRI EIANSELDDM VIFRPDGYPT YNFAVVVDDW DMGITEVIRG
210 220 230 240 250
DDHINNTPRQ INLYEGIGAP VPKFGHMPMI LDEQGAKLSK RTGAADVMQY
260 270 280 290 300
KDAGYLPDAL LSYLARLGWS HGDQELFSRQ ELIELFDVKD CNSKASRLDM
310 320 330 340 350
AKLGWVNQHF LKTEDVAAIV PHLVYQLQKL GLDVAAGPAP EDVVVALRER
360 370 380 390 400
VQTLKEMAEK AVVWYQPLTE YDEAAVAKHF KAGAEVALGK ARELLAALPE
410 420 430 440 450
WTAESVGVAL HDAAAALEIG MGKVAQPLRV AITGTQVSPD ISHTVYLAGR
460
EQALKRIDVA ITKVATA
Length:467
Mass (Da):51,958
Last modified:June 10, 2008 - v1
Checksum:iA0FE17022FCF539B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM743169 Genomic DNA Translation: CAQ44980.1
RefSeqiWP_012479577.1, NC_010943.1

Genome annotation databases

EnsemblBacteriaiCAQ44980; CAQ44980; Smlt1441
GeneIDi6395379
KEGGisml:Smlt1441
PATRICifig|522373.3.peg.1379

Similar proteinsi

Entry informationi

Entry nameiSYE_STRMK
AccessioniPrimary (citable) accession number: B2FHI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: June 10, 2008
Last modified: March 28, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health