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Protein

Venom carboxylesterase-6

Gene
N/A
Organism
Apis mellifera (Honeybee)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A carboxylic ester + H2O = an alcohol + a carboxylate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei212Acyl-ester intermediatePROSITE-ProRule annotation1
Active sitei341Charge relay systemBy similarity1
Active sitei464Charge relay systemBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Protein family/group databases

ESTHERiapime-b2d0j5. Carb_B_Arthropoda.

Names & Taxonomyi

Protein namesi
Recommended name:
Venom carboxylesterase-6 (EC:3.1.1.1)
Alternative name(s):
Allergen: Api m 8
OrganismiApis mellifera (Honeybee)
Taxonomic identifieri7460 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataApoideaApidaeApis
Proteomesi
  • UP000005203 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.By similarity

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei5756. Api m 8.
5757. Api m 8.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500033698822 – 557Venom carboxylesterase-6Add BLAST536

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi88 ↔ 108By similarity
Glycosylationi145N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi264 ↔ 275By similarity
Glycosylationi374N-linked (GlcNAc...)Sequence analysis1
Glycosylationi478N-linked (GlcNAc...)Sequence analysis1
Glycosylationi528N-linked (GlcNAc...)Sequence analysis1
Glycosylationi542N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiB2D0J5.

Expressioni

Tissue specificityi

Expressed by the venom duct.

Interactioni

Protein-protein interaction databases

STRINGi7460.GB10820-PA.

Structurei

3D structure databases

ProteinModelPortaliB2D0J5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1516. Eukaryota.
COG2272. LUCA.
PhylomeDBiB2D0J5.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B2D0J5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYMLKLSYIL LFLGFVKFSW QDKQVPKVST FTGNIRGYYK KSRSDRLYEA
60 70 80 90 100
YEGIPYAQSP VGKFRFQPPR PIKKWSKDLS ATKKSSVCMQ YLMTFTTHGN
110 120 130 140 150
RVKGSEDCLY INIYVPVRNN RKPLLPVMFW IHGGAFQFAS GNEANETLFM
160 170 180 190 200
DRNIVFVAIN YRLGPFGFLS TGDIVVPGNM GLKDQSMALR WVFNNIKSFG
210 220 230 240 250
GNPNKITIFG MSAGGASVHY HYLSPMSAGL FKRGISISGV AFCPWAQTKH
260 270 280 290 300
APEKAKKLGA LMKCRTDNTK KMIDCLQSRP ARIIAQAVGD FMFWLYNPFT
310 320 330 340 350
PFGPVVETYG SNPFISNSPI NIINNGQVYD VPWISGVVSK EGLYTAAEFV
360 370 380 390 400
DNAKLLWHLN DHWDEIAPYL LDFNYTIPLD QHRQVAKKIK NYYLRSGPIN
410 420 430 440 450
YDKVESIIQM MSDRLFNIDF EKAVRLQARI NKSPVWTYYY SYRAEHSVSE
460 470 480 490 500
ILSGGSTTDY GVCHGDDIFL TLNSIISNVT KPQDLAMQQL LINFYTSFAI
510 520 530 540 550
QGIPYIDEAS WPSLNPNDPD FRYLHIVNFT NIKMEVNNNF ANKSFWKTIP

FNENKLN
Length:557
Mass (Da):63,637
Last modified:May 20, 2008 - v1
Checksum:i804E1ED11DA92D25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU564833 mRNA. Translation: ACB70231.1.
RefSeqiNP_001119716.1. NM_001126244.1.
UniGeneiAme.14604.

Genome annotation databases

GeneIDi410928.
KEGGiame:410928.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU564833 mRNA. Translation: ACB70231.1.
RefSeqiNP_001119716.1. NM_001126244.1.
UniGeneiAme.14604.

3D structure databases

ProteinModelPortaliB2D0J5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7460.GB10820-PA.

Protein family/group databases

Allergomei5756. Api m 8.
5757. Api m 8.0101.
ESTHERiapime-b2d0j5. Carb_B_Arthropoda.

Proteomic databases

PaxDbiB2D0J5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi410928.
KEGGiame:410928.

Organism-specific databases

CTDi39392.

Phylogenomic databases

eggNOGiKOG1516. Eukaryota.
COG2272. LUCA.
PhylomeDBiB2D0J5.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEST6_APIME
AccessioniPrimary (citable) accession number: B2D0J5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: May 20, 2008
Last modified: November 11, 2015
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.