Reviewed, UniProtKB/Swiss-Prot B2CNY4 (KAD1_PENMA)

Names and origin

Protein names

Recommended name:
    Adenylate kinase 1
      Short name=AK 1
    EC=2.7.4.3
Alternative name(s):
    ATP-AMP transphosphorylase 1
    Adenylate kinase cytosolic and mitochondrial

Gene names

Name:

adk1

Organism

Penicillium marneffei

Taxonomic identifier

37727 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Penicillium

Protein attributes

Sequence length	272 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth. Functions both in cytoplasm and mitochondrion intermembrane space By similarity.
Catalytic activity	ATP + AMP = 2 ADP.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm › cytosol By similarity. Mitochondrion intermembrane space By similarity.
Sequence similarities	Belongs to the adenylate kinase family. AK2 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm Mitochondrion
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological process	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial intermembrane space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 272	272	Adenylate kinase 1		PRO_0000365681
Regions
	Nucleotide binding	52 – 60	9	ATP By similarity
	Nucleotide binding	75 – 104	30	AMP By similarity
Sites
	Binding site	76	1	AMP By similarity

Sequences

	Sequence		Length	Mass (Da)
	B2CNY4-1 [UniParc]. Last modified May 20, 2008. Version 1. Checksum: 659ABBEC66C4F4EE	FASTA	272	29,843
	10 20 30 40 50 60 MAPITQETVD GLKDIIHKLE SRVADLESRL VHGSPASNSK SLAEQFRIIL IGPPGAGKGT 70 80 90 100 110 120 QAPRLKEKYC VCHLATGDML RSQVAKKTPL GKEAKKIMDQ GGLVSDEIMV NMIKSELETN 130 140 150 160 170 180 SECKNGFILD GFPRTVAQAE RLDDMLSARN EKLQHAVELQ IDDALLVARI TGRLVHPASG 190 200 210 220 230 240 RSYHKIFNPP KQDMKDDITG EPLIQRSDDN AATLEKRLAT YHAQTSPVVD YYKKTGIWCG 250 260 270 IDASQEPGQV WKSLLGVFQP SSSILSKVGL SK

References

[1]	"Penicillium marneffei adenylate kinase." Chandler J.M., Walker G.R., Cooper C.R. Jr. Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: F4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	EU532187 Genomic DNA. Translation: ACB30375.1.
3D structure databases
SMR	B2CNY4. Positions 44-255.
ModBase	Search...
Family and domain databases
InterPro	IPR006259. Adenyl_kin_sub. IPR000850. Adenylate_kin. IPR007862. Adenylate_kinase_lid-dom. [Graphical view]
PANTHER	PTHR23359. Adenylate_kin. 1 hit.
Pfam	PF00406. ADK. 1 hit. PF05191. ADK_lid. 1 hit. [Graphical view]
PRINTS	PR00094. ADENYLTKNASE.
TIGRFAMs	TIGR01351. adk. 1 hit.
PROSITE	PS00113. ADENYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAD1_PENMA

Accession

Primary (citable) accession number: B2CNY4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	May 20, 2008
Last modified:	February 9, 2010
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)