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B2BRG2 (NSP1_ROTW3) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Non-structural protein 1

Short name=NSP1
Alternative name(s):
NCVP2
Non-structural RNA-binding protein 53
Short name=NS53
OrganismRotavirus A (strain Cow/United States/WC3/1981 G6-P7[5]-I2-R2-C2-M2-A3-N2-T6-E2-H3) (RV-A) (Rotavirus (strain Wistar calf 3)) [Complete proteome]
Taxonomic identifier578828 [NCBI]
Taxonomic lineageVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirusRotavirus A
Virus hostBos taurus (Bovine) [TaxID: 9913]

Protein attributes

Sequence length491 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Seems to induce the proteasome-dependent degradation of IRF3, IRF5 and IRF7, thereby antagonizing the cellular interferon response and establishment of the antiviral state. Binds and targets IRF3 early post-infection and suppresses IRF3 nuclear translocation By similarity.

Subunit structure

Interacts (via C-terminus) with host IRF3; this interaction leads to IRF3 degradation. Interacts with host IRF7; this interaction leads to IRF7 degradation By similarity.

Subcellular location

Host cytoplasmhost cytoskeleton By similarity.

Domain

The zinc-finger domain is important, but not sufficient for binding and degrading IRF3. It is sometimes described as a RING zinc-finger, but it is atypical and it is unclear whether it is related with ubiquitin ligase activity By similarity.

Sequence similarities

Belongs to the rotavirus A NSP1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 491491Non-structural protein 1
PRO_0000369080

Regions

Zinc finger42 – 7938 Potential
Region1 – 8181RNA-binding By similarity
Region82 – 17695Important for cytoskeleton localization By similarity
Region316 – 491176Interaction with IRF3 By similarity

Sequences

Sequence LengthMass (Da)Tools
B2BRG2 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: AA783A9129B61F8C

FASTA49158,610
        10         20         30         40         50         60 
MATFKDACYH YKKLNKLNSL VLKLGANDEW RPAPVTKYKG WCLDCCQYTN LTYCRGCALY 

        70         80         90        100        110        120 
HVCQWCSQYN RCFLDEEPHL LRMRTFKDVV TKEDIEGLLT MYETLFPINE KLVNKFINSV 

       130        140        150        160        170        180 
KQRKCRNEYL LEWYNHLLMP ITLQALTINL EDNVYYIFGY YDCMEHENQT PFQFINLLEK 

       190        200        210        220        230        240 
YDKLLLDDRN FHRMSHLPVI LQQEYALRYF SKSRFLSKGK KRLSRSDFSD SLMEDRHSPT 

       250        260        270        280        290        300 
SLMQVVRNCI SIHINDCEWN KACTLIVDAR NYISIMNSSY TEHYSVSQRC KLFTKYKFGI 

       310        320        330        340        350        360 
VSRLVKPNYI FSSHESCALN VHNCKWCQIN NHYKVWEDFR LRKIYNNVMD FIRALVKSNG 

       370        380        390        400        410        420 
NVGHCSSQES VYKYIPDLFL ICKTEKWNEA VEMLFNYLEP VDINGTEYVL LDYEVNWEVR 

       430        440        450        460        470        480 
GLVMQNMDGK VPRILNMNDT KKILSAMIFD WFDTRYMRET PMTTSTTNQL RTLNKRNELI 

       490 
DEYDLELSDV E 

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References

[1]"Full genome-based classification of rotaviruses reveals a common origin between human Wa-Like and porcine rotavirus strains and human DS-1-like and bovine rotavirus strains."
Matthijnssens J., Ciarlet M., Heiman E.M., Arijs I., Delbeke T., McDonald S.M., Palombo E.A., Iturriza-Gomara M., Maes P., Patton J.T., Rahman M., Van Ranst M.
J. Virol. 82:3204-3219(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EF990699 Genomic RNA. Translation: ABV66088.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR002148. Rotavirus_NSP1.
[Graphical view]
PfamPF00981. Rota_NS53. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNSP1_ROTW3
AccessionPrimary (citable) accession number: B2BRG2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 20, 2008
Last modified: February 19, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families