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Protein
Submitted name:

Metabotropic glutamate receptor subtype 5b

Gene

Grm5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptorSAAS annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Metabotropic glutamate receptor subtype 5bImported
Gene namesi
Name:Grm5Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1351342. Grm5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei580 – 603HelicalSequence analysisAdd BLAST24
Transmembranei615 – 638HelicalSequence analysisAdd BLAST24
Transmembranei686 – 713HelicalSequence analysisAdd BLAST28
Transmembranei739 – 758HelicalSequence analysisAdd BLAST20
Transmembranei770 – 792HelicalSequence analysisAdd BLAST23
Transmembranei798 – 825HelicalSequence analysisAdd BLAST28

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_500994726019 – 1203Sequence analysisAdd BLAST1185

Proteomic databases

PaxDbiB2BH30.
PeptideAtlasiB2BH30.
PRIDEiB2BH30.

Expressioni

Gene expression databases

BgeeiENSMUSG00000049583.
ExpressionAtlasiB2BH30. baseline and differential.
GenevisibleiB2BH30. MM.

Structurei

3D structure databases

ProteinModelPortaliB2BH30.
SMRiB2BH30.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini578 – 840G_PROTEIN_RECEP_F3_4InterPro annotationAdd BLAST263

Sequence similaritiesi

Belongs to the G-protein coupled receptor 3 family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1056. Eukaryota.
ENOG410XR6W. LUCA.
HOVERGENiHBG107965.
KOiK04604.
OMAiYRPQTPS.
OrthoDBiEOG091G177R.
PhylomeDBiB2BH30.

Family and domain databases

InterProiView protein in InterPro
IPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR000202. GPCR_3_mtglu_rcpt_5.
IPR019588. Metabotropic_Glu_rcpt_Homer-bd.
IPR028082. Peripla_BP_I.
PfamiView protein in Pfam
PF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF10606. GluR_Homer-bdg. 1 hit.
PF07562. NCD3G. 1 hit.
PRINTSiPR00248. GPCRMGR.
PR01055. MTABOTROPC5R.
PR00593. MTABOTROPICR.
SMARTiView protein in SMART
SM01229. GluR_Homer-bdg. 1 hit.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiView protein in PROSITE
PS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.

Sequencei

Sequence statusi: Complete.

B2BH30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLLLILSVL LLKEDVRGSA QSSERRVVAH MPGDIIIGAL FSVHHQPTVD
60 70 80 90 100
KVHERKCGAV REQYGIQRVE AMLHTLERIN SDPTLLPNIT LGCEIRDSCW
110 120 130 140 150
HSAVALEQSI EFIRDSLISS EEEEGLVRCV DGSSSFRSKK PIVGVIGPGS
160 170 180 190 200
SSVAIQVQNL LQLFNIPQIA YSATSMDLSD KTLFKYFMRV VPSDAQQARA
210 220 230 240 250
MVDIVKRYNW TYVSAVHTEG NYGESGMEAF KDMSAKEGIC IAHSYKIYSN
260 270 280 290 300
AGEQSFDKLL KKLRSHLPKA RVVACFCEGM TVRGLLMAMR RLGLAGEFLL
310 320 330 340 350
LGSDGWADRY DVTDGYQREA VGGITIKLQS PDVKWFDDYY LKLRPETNLR
360 370 380 390 400
NPWFQEFWQH RFQCRLEGFA QENSKYNKTC NSSLTLRTHH VQDSKMGFVI
410 420 430 440 450
NAIYSMAYGL HNMQMSLCPG YAGLCDAMKP IDGRKLLDSL MKTNFTGVSG
460 470 480 490 500
DMILFDENGD SPGRYEIMNF KEMGKDYFDY INVGSWDNGE LKMDDDEVWS
510 520 530 540 550
KKNNIIRSVC SEPCEKGQIK VIRKGEVSCC WTCTPCKENE YVFDEYTCKA
560 570 580 590 600
CQLGSWPTDD LTGCDLIPVQ YLRWGDPEPI AAVVFACLGL LATLFVTVIF
610 620 630 640 650
IIYRDTPVVK SSSRELCYII LAGICLGYLC TFCLIAKPKQ IYCYLQRIGI
660 670 680 690 700
GLSPAMSYSA LVTKTNRIAR ILAGSKKKIC TKKPRFMSAC AQLVIAFILI
710 720 730 740 750
CIQLGIIVAL FIMEPPDIMH DYPSIREVYL ICNTTNLGVV TPLGYNGLLI
760 770 780 790 800
LSCTFYAFKT RNVPANFNEA KYIAFTMYTT CIIWLAFVPI YFGSNYKIIT
810 820 830 840 850
MCFSVSLSAT VALGCMFVPK VYIILAKPER NVRSAFTTST VVRMHVGDGK
860 870 880 890 900
SSSAASRSSS LVNLWKRRGS SGETLRYKDR RLAQHKSEIE CFTPKGSMGN
910 920 930 940 950
GGRATMSSSN GKSVTWAQNE KSTRGQHLWQ RLSVHINKKE NPNQTAVIKP
960 970 980 990 1000
FPKSTESRGQ GAGAGGGSGP GAAGAGSAGC TATGGPEPPD AGPKALYDVA
1010 1020 1030 1040 1050
EAEERFPAAA RPRSPSPIST LSHLAGSAGR TDDDAPSLHS ETAARSSSSQ
1060 1070 1080 1090 1100
GSLMEQISSV VTRFTANITE LNSMMLSTAA APGPPGTPIC SSYLIPKEIQ
1110 1120 1130 1140 1150
LPTTMTTFAE IQPLPAIEVT GGAQPATGPS PAQETPAGAE AAPGKPDLEE
1160 1170 1180 1190 1200
LVALTPPSPF RDSVDSGSTT PNSPVSESAL CIPSSPKYDT LIIRDYTQSS

SSL
Length:1,203
Mass (Da):131,865
Last modified:May 20, 2008 - v1
Checksum:i2A09D7EC272ED23C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF508472 mRNA. Translation: ABS30420.1.
RefSeqiNP_001137306.1. NM_001143834.1.
XP_011239945.1. XM_011241643.2.
UniGeneiMm.235018.

Genome annotation databases

GeneIDi108071.
KEGGimmu:108071.

Similar proteinsi

Entry informationi

Entry nameiB2BH30_MOUSE
AccessioniPrimary (citable) accession number: B2BH30
Secondary accession number(s): F6YJ89
Entry historyiIntegrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: October 25, 2017
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)