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B2B762

- KEX1_PODAN

UniProt

B2B762 - KEX1_PODAN

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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei135 – 1351PROSITE-ProRule annotation
Active sitei335 – 3351PROSITE-ProRule annotation
Active sitei397 – 3971PROSITE-ProRule annotation

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
Ordered Locus Names:PODANS_2_10030
OrganismiPodospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
Taxonomic identifieri515849 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesLasiosphaeriaceaePodospora
ProteomesiUP000001197: Chromosome 2

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 585567Pheromone-processing carboxypeptidase KEX1PRO_0000411941Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi386 – 3861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi394 – 3941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi447 – 4471N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliB2B762.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 469451LumenalSequence AnalysisAdd
BLAST
Topological domaini491 – 58595CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei470 – 49021HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK01288.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B2B762-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCLLARVRHI EITPDVNGNM FFWHFQNKHI ANKQRTVIWL NGGPGCSSED
60 70 80 90 100
GALMEIGPYR LKDKDTLVYN EGAWNEFANV LFVDNPVGTG FSYVDTNAYV
110 120 130 140 150
RELDVMADQF VTFLEKWFKL FPEYEHDDIF IAGESYAGQY IPYIAKAILE
160 170 180 190 200
RNKKGGESSY KWNLAGLLIG NGWISPPEQY EAYLQFAYEK GIVKKGSDAA
210 220 230 240 250
SKLEVQQRIC SKQLAVGPAL VDNTDCEKIL QDLLQLTATS KGGEQRCVNM
260 270 280 290 300
YDVRLTDTYP SCGMNWPPDL DAVTPYLRRN DVIQALHVNP NKVTGWVECN
310 320 330 340 350
GQVGANFKPS SKPSVELLPD LLKEVPIILF SGSEDLICNH LGTEALISNL
360 370 380 390 400
QWNGGKGFEI TPGTWAPRRD WTFEGEAAGF WQEARNLTYV VFYNSSHMVP
410 420 430 440 450
FDYPRRTRDM LDRFMGVDIS SIGGKPTDSR LDGEKVPETT VGGVAGNGTD
460 470 480 490 500
AQQAEKEKLD TARWEAYRKS GEIVLVIVAF SAAGWGWWVW RERKKRRGYM
510 520 530 540 550
GVSGGENISP SGEARGREGF RDKRSAADLE AGDFDENELD DLHMRTPTTV
560 570 580
MGGEGNDPRY SVGAASEDSE DEEDVKGKGK EKMSG
Length:585
Mass (Da):65,374
Last modified:May 20, 2008 - v1
Checksum:i84EDD573F229D2BB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU640366 Genomic DNA. Translation: CAP73640.1.
RefSeqiXP_001911812.1. XM_001911777.1.

Genome annotation databases

GeneIDi6195504.
KEGGipan:PODANSg8857.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU640366 Genomic DNA. Translation: CAP73640.1 .
RefSeqi XP_001911812.1. XM_001911777.1.

3D structure databases

ProteinModelPortali B2B762.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 6195504.
KEGGi pan:PODANSg8857.

Phylogenomic databases

KOi K01288.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S / ATCC MYA-4624 / DSM 980 / FGSC 10383.

Entry informationi

Entry nameiKEX1_PODAN
AccessioniPrimary (citable) accession number: B2B762
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: May 20, 2008
Last modified: October 29, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3