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B2B762

- KEX1_PODAN

UniProt

B2B762 - KEX1_PODAN

Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (20 May 2008)
      Previous versions | rss
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    Functioni

    Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.By similarity

    Catalytic activityi

    Preferential release of a C-terminal arginine or lysine residue.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei135 – 1351PROSITE-ProRule annotation
    Active sitei335 – 3351PROSITE-ProRule annotation
    Active sitei397 – 3971PROSITE-ProRule annotation

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Keywords - Biological processi

    Apoptosis

    Protein family/group databases

    MEROPSiS10.007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
    Alternative name(s):
    Carboxypeptidase D
    Gene namesi
    Name:KEX1
    Ordered Locus Names:PODANS_2_10030
    OrganismiPodospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
    Taxonomic identifieri515849 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesLasiosphaeriaceaePodospora
    ProteomesiUP000001197: Chromosome 2

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 585567Pheromone-processing carboxypeptidase KEX1PRO_0000411941Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi386 – 3861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi394 – 3941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi447 – 4471N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliB2B762.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini19 – 469451LumenalSequence AnalysisAdd
    BLAST
    Topological domaini491 – 58595CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei470 – 49021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    KOiK01288.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B2B762-1 [UniParc]FASTAAdd to Basket

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    MCLLARVRHI EITPDVNGNM FFWHFQNKHI ANKQRTVIWL NGGPGCSSED    50
    GALMEIGPYR LKDKDTLVYN EGAWNEFANV LFVDNPVGTG FSYVDTNAYV 100
    RELDVMADQF VTFLEKWFKL FPEYEHDDIF IAGESYAGQY IPYIAKAILE 150
    RNKKGGESSY KWNLAGLLIG NGWISPPEQY EAYLQFAYEK GIVKKGSDAA 200
    SKLEVQQRIC SKQLAVGPAL VDNTDCEKIL QDLLQLTATS KGGEQRCVNM 250
    YDVRLTDTYP SCGMNWPPDL DAVTPYLRRN DVIQALHVNP NKVTGWVECN 300
    GQVGANFKPS SKPSVELLPD LLKEVPIILF SGSEDLICNH LGTEALISNL 350
    QWNGGKGFEI TPGTWAPRRD WTFEGEAAGF WQEARNLTYV VFYNSSHMVP 400
    FDYPRRTRDM LDRFMGVDIS SIGGKPTDSR LDGEKVPETT VGGVAGNGTD 450
    AQQAEKEKLD TARWEAYRKS GEIVLVIVAF SAAGWGWWVW RERKKRRGYM 500
    GVSGGENISP SGEARGREGF RDKRSAADLE AGDFDENELD DLHMRTPTTV 550
    MGGEGNDPRY SVGAASEDSE DEEDVKGKGK EKMSG 585
    Length:585
    Mass (Da):65,374
    Last modified:May 20, 2008 - v1
    Checksum:i84EDD573F229D2BB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU640366 Genomic DNA. Translation: CAP73640.1.
    RefSeqiXP_001911812.1. XM_001911777.1.

    Genome annotation databases

    GeneIDi6195504.
    KEGGipan:PODANSg8857.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU640366 Genomic DNA. Translation: CAP73640.1 .
    RefSeqi XP_001911812.1. XM_001911777.1.

    3D structure databases

    ProteinModelPortali B2B762.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S10.007.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 6195504.
    KEGGi pan:PODANSg8857.

    Phylogenomic databases

    KOi K01288.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: S / ATCC MYA-4624 / DSM 980 / FGSC 10383.

    Entry informationi

    Entry nameiKEX1_PODAN
    AccessioniPrimary (citable) accession number: B2B762
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3