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B2B762

- KEX1_PODAN

UniProt

B2B762 - KEX1_PODAN

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Protein
Pheromone-processing carboxypeptidase KEX1
Gene
KEX1, PODANS_2_10030
Organism
Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei135 – 1351 By similarity
Active sitei335 – 3351 By similarity
Active sitei397 – 3971 By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
Ordered Locus Names:PODANS_2_10030
OrganismiPodospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
Taxonomic identifieri515849 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesLasiosphaeriaceaePodospora
ProteomesiUP000001197: Chromosome 2

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 469451Lumenal Reviewed prediction
Add
BLAST
Transmembranei470 – 49021Helical; Reviewed prediction
Add
BLAST
Topological domaini491 – 58595Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Chaini19 – 585567Pheromone-processing carboxypeptidase KEX1
PRO_0000411941Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi386 – 3861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi394 – 3941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi447 – 4471N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliB2B762.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK01288.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B2B762-1 [UniParc]FASTAAdd to Basket

« Hide

MCLLARVRHI EITPDVNGNM FFWHFQNKHI ANKQRTVIWL NGGPGCSSED    50
GALMEIGPYR LKDKDTLVYN EGAWNEFANV LFVDNPVGTG FSYVDTNAYV 100
RELDVMADQF VTFLEKWFKL FPEYEHDDIF IAGESYAGQY IPYIAKAILE 150
RNKKGGESSY KWNLAGLLIG NGWISPPEQY EAYLQFAYEK GIVKKGSDAA 200
SKLEVQQRIC SKQLAVGPAL VDNTDCEKIL QDLLQLTATS KGGEQRCVNM 250
YDVRLTDTYP SCGMNWPPDL DAVTPYLRRN DVIQALHVNP NKVTGWVECN 300
GQVGANFKPS SKPSVELLPD LLKEVPIILF SGSEDLICNH LGTEALISNL 350
QWNGGKGFEI TPGTWAPRRD WTFEGEAAGF WQEARNLTYV VFYNSSHMVP 400
FDYPRRTRDM LDRFMGVDIS SIGGKPTDSR LDGEKVPETT VGGVAGNGTD 450
AQQAEKEKLD TARWEAYRKS GEIVLVIVAF SAAGWGWWVW RERKKRRGYM 500
GVSGGENISP SGEARGREGF RDKRSAADLE AGDFDENELD DLHMRTPTTV 550
MGGEGNDPRY SVGAASEDSE DEEDVKGKGK EKMSG 585
Length:585
Mass (Da):65,374
Last modified:May 20, 2008 - v1
Checksum:i84EDD573F229D2BB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU640366 Genomic DNA. Translation: CAP73640.1.
RefSeqiXP_001911812.1. XM_001911777.1.

Genome annotation databases

GeneIDi6195504.
KEGGipan:PODANSg8857.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU640366 Genomic DNA. Translation: CAP73640.1 .
RefSeqi XP_001911812.1. XM_001911777.1.

3D structure databases

ProteinModelPortali B2B762.
ModBasei Search...

Protein family/group databases

MEROPSi S10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 6195504.
KEGGi pan:PODANSg8857.

Phylogenomic databases

KOi K01288.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S / ATCC MYA-4624 / DSM 980 / FGSC 10383.

Entry informationi

Entry nameiKEX1_PODAN
AccessioniPrimary (citable) accession number: B2B762
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: May 20, 2008
Last modified: June 11, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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