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B2B762 (KEX1_PODAN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pheromone-processing carboxypeptidase KEX1

EC=3.4.16.6
Alternative name(s):
Carboxypeptidase D
Gene names
Name:KEX1
Ordered Locus Names:PODANS_2_10030
OrganismPodospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina) [Complete proteome]
Taxonomic identifier515849 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesLasiosphaeriaceaePodospora

Protein attributes

Sequence length585 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activity

Preferential release of a C-terminal arginine or lysine residue.

Subcellular location

Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentGolgi apparatus
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 585567Pheromone-processing carboxypeptidase KEX1
PRO_0000411941

Regions

Topological domain19 – 469451Lumenal Potential
Transmembrane470 – 49021Helical; Potential
Topological domain491 – 58595Cytoplasmic Potential

Sites

Active site1351 By similarity
Active site3351 By similarity
Active site3971 By similarity

Amino acid modifications

Glycosylation3861N-linked (GlcNAc...) Potential
Glycosylation3941N-linked (GlcNAc...) Potential
Glycosylation4471N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
B2B762 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: 84EDD573F229D2BB

FASTA58565,374
        10         20         30         40         50         60 
MCLLARVRHI EITPDVNGNM FFWHFQNKHI ANKQRTVIWL NGGPGCSSED GALMEIGPYR 

        70         80         90        100        110        120 
LKDKDTLVYN EGAWNEFANV LFVDNPVGTG FSYVDTNAYV RELDVMADQF VTFLEKWFKL 

       130        140        150        160        170        180 
FPEYEHDDIF IAGESYAGQY IPYIAKAILE RNKKGGESSY KWNLAGLLIG NGWISPPEQY 

       190        200        210        220        230        240 
EAYLQFAYEK GIVKKGSDAA SKLEVQQRIC SKQLAVGPAL VDNTDCEKIL QDLLQLTATS 

       250        260        270        280        290        300 
KGGEQRCVNM YDVRLTDTYP SCGMNWPPDL DAVTPYLRRN DVIQALHVNP NKVTGWVECN 

       310        320        330        340        350        360 
GQVGANFKPS SKPSVELLPD LLKEVPIILF SGSEDLICNH LGTEALISNL QWNGGKGFEI 

       370        380        390        400        410        420 
TPGTWAPRRD WTFEGEAAGF WQEARNLTYV VFYNSSHMVP FDYPRRTRDM LDRFMGVDIS 

       430        440        450        460        470        480 
SIGGKPTDSR LDGEKVPETT VGGVAGNGTD AQQAEKEKLD TARWEAYRKS GEIVLVIVAF 

       490        500        510        520        530        540 
SAAGWGWWVW RERKKRRGYM GVSGGENISP SGEARGREGF RDKRSAADLE AGDFDENELD 

       550        560        570        580 
DLHMRTPTTV MGGEGNDPRY SVGAASEDSE DEEDVKGKGK EKMSG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU640366 Genomic DNA. Translation: CAP73640.1.
RefSeqXP_001911812.1. XM_001911777.1.

3D structure databases

ProteinModelPortalB2B762.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS10.007.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6195504.
KEGGpan:PODANSg8857.

Phylogenomic databases

KOK01288.

Family and domain databases

Gene3D3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
SUPFAMSSF53474. SSF53474. 1 hit.
PROSITEPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKEX1_PODAN
AccessionPrimary (citable) accession number: B2B762
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: May 20, 2008
Last modified: June 11, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries