Reviewed, UniProtKB/Swiss-Prot B2B0E2 (KAD1_PODAN)

Names and origin

Protein names

Recommended name:
    Adenylate kinase 1
      Short name=AK 1
    EC=2.7.4.3
Alternative name(s):
    ATP-AMP transphosphorylase 1
    Adenylate kinase cytosolic and mitochondrial

Gene names

Name:	ADK1
ORF Names:	Pa_3_5380

Organism

Podospora anserina

Taxonomic identifier

5145 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Lasiosphaeriaceae › Podospora

Protein attributes

Sequence length	276 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth. Functions both in cytoplasm and mitochondrion intermembrane space By similarity.
Catalytic activity	ATP + AMP = 2 ADP.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm › cytosol By similarity. Mitochondrion intermembrane space By similarity.
Sequence similarities	Belongs to the adenylate kinase family. AK2 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm Mitochondrion
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological process	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial intermembrane space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 276	276	Adenylate kinase 1		PRO_0000365685
Regions
	Nucleotide binding	48 – 56	9	ATP By similarity
	Nucleotide binding	71 – 100	30	AMP By similarity
Sites
	Binding site	72	1	AMP By similarity

Sequences

	Sequence		Length	Mass (Da)
	B2B0E2-1 [UniParc]. Last modified May 20, 2008. Version 1. Checksum: 18B8E338BFFB7E34	FASTA	276	30,374
	10 20 30 40 50 60 MGYIDDEVKR LQGVIANLEG RVQALETKQF GPSSQKKTVE EVRAILIGPP GAGKGTQAPR 70 80 90 100 110 120 LKEKFNCCHL ATGDMLRSQV AKKTPLGQAA KKIMDAGGLV SDEIVIGMIK EELDNNKECK 130 140 150 160 170 180 GGFILDGFPR TVPQAEGLDK MLRERNQTLQ HAVELKIDDE LLVARITGRL VHPASGRSYH 190 200 210 220 230 240 VKFNPPKKEM TDDITGEPLI QRSDDNADAL KKRLETYHKQ TTPVVNYYQK TGIWKAIDAS 250 260 270 QEPGQVWKSL LAIFDGDKSK ASKAGSTILS KLTHSS

References

[1]

"The genome sequence of the model ascomycete fungus Podospora anserina." Espagne E., Lespinet O., Malagnac F., Da Silva C., Jaillon O., Porcel B.M., Couloux A., Aury J.-M., Segurens B., Poulain J., Anthouard V., Grossetete S., Khalili H., Coppin E., Dequard-Chablat M., Picard M., Contamine V., Arnaise S. , Bourdais A., Berteaux-Lecellier V., Gautheret D., de Vries R.P., Battaglia E., Coutinho P.M., Danchin E.G.J., Henrissat B., El Khoury R., Sainsard-Chanet A., Boivin A., Pinan-Lucarre B., Sellem C.H., Debuchy R., Wincker P., Weissenbach J., Silar P. Genome Biol. 9:RESEARCH77.1-RESEARCH77.22(2008) [PubMed: 18460219] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: S.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CU638743 Genomic DNA. Translation: CAP70464.1.
RefSeq	XP_001909332.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6193333.
KEGG	pan:PODANSg6367.
Family and domain databases
InterPro	IPR006259. Adenyl_kin_sub. IPR000850. Adenylate_kin. IPR007862. Adenylate_kinase_Znf_lid. [Graphical view]
PANTHER	PTHR23359. Adenylate_kin. 1 hit.
Pfam	PF00406. ADK. 1 hit. PF05191. ADK_lid. 1 hit. [Graphical view]
PRINTS	PR00094. ADENYLTKNASE.
TIGRFAMs	TIGR01351. adk. 1 hit.
PROSITE	PS00113. ADENYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAD1_PODAN

Accession

Primary (citable) accession number: B2B0E2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	May 20, 2008
Last modified:	October 13, 2009
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)