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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

PODANS_1_9290

Organism
Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).UniRule annotation

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

FADUniRule annotation

Pathway:itricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (PODANS_1_9290), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (PODANS_1_8920)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Electron transportUniRule annotation, Transport, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

FADUniRule annotation, Flavoprotein, UbiquinoneImported

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialUniRule annotation (EC:1.3.5.1UniRule annotation)
Gene namesi
ORF Names:PODANS_1_9290Imported
OrganismiPodospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)Imported
Taxonomic identifieri515849 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesLasiosphaeriaceaePodospora
ProteomesiUP000001197 Componenti: Chromosome 1

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Matrix side UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

MembraneUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi515849.XP_001908590.1.

Structurei

3D structure databases

ProteinModelPortaliB2AXY9.
SMRiB2AXY9. Positions 53-648.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Phylogenomic databases

KOiK00234.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2AXY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSMAWRRL AAAPALPRAL RTPTQRAFST TRPAARVIAN GPLRAKEASP
60 70 80 90 100
FVSSKYPVID HEYDAIVVGA GGAGLRAAFG LAEAGFNTAC ISKLFPTRSH
110 120 130 140 150
TVAAQGGINA ALGNMHKDDW RWHMYDTVKG SDWLGDQDAI HYMTREAPAS
160 170 180 190 200
IIELENYGCP FSRTEDGKIY QRAFGGQSKE YGKGGQAYRC CAAADRTGHA
210 220 230 240 250
LLHTLYGQSL RHNTNYFIEY FAIDLIMQDG ECRGVLAYNQ EDGTLHRFLA
260 270 280 290 300
NNTVLATGGY GRAYFSCTSA HTCTGDGMAM VARAGLPNQD LEFVQFHPTG
310 320 330 340 350
IYGAGCLITE GARGEGGYLL NSEGERFMER YAPTAKDLAS RDVVSRSMTM
360 370 380 390 400
EIRDGRGVGA EKDHIYLQLS HLPAEILAER LPGISETAGI FAGVDVRKQP
410 420 430 440 450
IPVLPTVHYN MGGIPTRYTG EVLTVDESGN DKVVPGLFAC GEAACVSVHG
460 470 480 490 500
ANRLGANSLL DLVVFGRAVA HTIRDNFTPG AKLKPVEADA GAAEIEMLDK
510 520 530 540 550
IRTADGPKST AEIRLAMQKT MQRDVSVFRT QESLDEGVEK INQVDQTFSQ
560 570 580 590 600
VGIKDRSMIW NSDLVETLEL RNLLTCAVQT ATAAANRKES RGAHAREDYP
610 620 630 640
DRDDENWMKH TLTWQKPHGK VDLKYRRVIG TTLDENECKP VPPFKRVY
Length:648
Mass (Da):70,906
Last modified:May 20, 2008 - v1
Checksum:iFFA826023AE49EAB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU633901 Genomic DNA. Translation: CAP69263.1.
FO904936 Genomic DNA. Translation: CDP23282.1.
RefSeqiXP_001908590.1. XM_001908555.1.

Genome annotation databases

GeneIDi6193320.
KEGGipan:PODANSg5625.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU633901 Genomic DNA. Translation: CAP69263.1.
FO904936 Genomic DNA. Translation: CDP23282.1.
RefSeqiXP_001908590.1. XM_001908555.1.

3D structure databases

ProteinModelPortaliB2AXY9.
SMRiB2AXY9. Positions 53-648.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi515849.XP_001908590.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi6193320.
KEGGipan:PODANSg5625.

Phylogenomic databases

KOiK00234.

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S / ATCC MYA-4624 / DSM 980 / FGSC 10383Imported and S mat+Imported.
  2. Genoscope - CEA
    Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: S mat+Imported.
  3. Genoscope - CEA
    Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  4. "Maintaining two mating types: Structure of the mating type locus and its role in heterokaryosis in Podospora anserina."
    Grognet P., Bidard F., Kuchly C., Chan Ho Tong L., Coppin E., Ait Benkhali J., Couloux A., Wincker P., Debuchy R., Silar P.
    Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiB2AXY9_PODAN
AccessioniPrimary (citable) accession number: B2AXY9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: July 22, 2015
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.