B2AWV6 (AMPP1_PODAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase P
Short name=AMPP
Short name=Aminopeptidase P
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

Name:	AMPP
ORF Names:	Pa_7_8470

Organism

Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina) [Complete proteome]

Taxonomic identifier

515849 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › sordariomyceta › Sordariomycetes › Sordariomycetidae › Sordariales › Lasiosphaeriaceae › Podospora › Podospora anserina

Protein attributes

Sequence length	680 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 680	680	Probable Xaa-Pro aminopeptidase P		PRO_0000411806
Sites
	Metal binding	477	1	Manganese 2 By similarity
	Metal binding	488	1	Manganese 1 By similarity
	Metal binding	488	1	Manganese 2 By similarity
	Metal binding	586	1	Manganese 1 By similarity
	Metal binding	600	1	Manganese 1 By similarity
	Metal binding	600	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	B2AWV6 [UniParc]. Last modified May 20, 2008. Version 1. Checksum: 37534DD2228663E8	FASTA	680	75,096
	10 20 30 40 50 60 MRHIWALPSL TALSLFQASA ASAVPRARQA INTSSPLAPF RTKRRFRTQA QLLSNSATKT 70 80 90 100 110 120 TLVEEMVTVD TTSRLAALRS LMKERNLHVY VVPSEDSHAS EYIADCDARR TFISGFSGSA 130 140 150 160 170 180 GTAIVTLDKA ALATDGRYFN QASKQLDSNW YLLKTGMQDV PTWQEWATQE AEGGKLIGVD 190 200 210 220 230 240 PQLISSAIAE KLDEDIKNAG GGGLVGIKEN LVDLVWGSEQ PPRPSNSVFL LGQQYAGKDT 250 260 270 280 290 300 AAKLADLRKE LDKKKAAGFV LSMLDEIAWL FNLRGSDIAY NPVFFSYAIV TQASATLYID 310 320 330 340 350 360 EAKLTDECKT YLERNKVTIK PYGALFEDSE ELARRAEADS KDAKPRKYLI SSKGSWALKL 370 380 390 400 410 420 ALGGNKFVDE VRSPVGDAKA VKNDVELNGM RNCHIRDGAA LTEFFAWLED QLVNQKAQLD 430 440 450 460 470 480 EVDAADKLEQ IRSKHKDFVG LSFDTISSTG ANAAVIHYKP EKGACKIIDP NAIYLCDSGA 490 500 510 520 530 540 QYLDGTTDTT RTLHFGTPTA KEKKAYTLVL KGNIALDSVV FPKGTSGFAI DVMARQFLWK 550 560 570 580 590 600 YGLDYRHGTG HGVGSFLNVH EGPIGIGTRK QYIDVALAAG NVLSIEPGYY EDEAFGIRIE 610 620 630 640 650 660 NLAIVKEVKT EHSFGDKPYL GFEHVTMVPY ARNLIDETLL TPDEKDWLNR ANKKILEKTL 670 680 GYFENDPLTK AWLLRETQPF

References

[1]

"The genome sequence of the model ascomycete fungus Podospora anserina." Espagne E., Lespinet O., Malagnac F., Da Silva C., Jaillon O., Porcel B.M., Couloux A., Aury J.-M., Segurens B., Poulain J., Anthouard V., Grossetete S., Khalili H., Coppin E., Dequard-Chablat M., Picard M., Contamine V., Arnaise S. , Bourdais A., Berteaux-Lecellier V., Gautheret D., de Vries R.P., Battaglia E., Coutinho P.M., Danchin E.G.J., Henrissat B., El Khoury R., Sainsard-Chanet A., Boivin A., Pinan-Lucarre B., Sellem C.H., Debuchy R., Wincker P., Weissenbach J., Silar P. Genome Biol. 9:R77.1-R77.22(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: S / ATCC MYA-4624 / DSM 980 / FGSC 10383.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU633900 Genomic DNA. Translation: CAP68880.1.
RefSeq	XP_001908207.1. XM_001908172.1.
3D structure databases
ProteinModelPortal	B2AWV6.
ModBase	Search...
Protein family/group databases
MEROPS	M24.003.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6192025.
KEGG	pan:PODANSg5242.
Phylogenomic databases
KO	K01262.
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR000587. Creatinase. IPR000994. Pept_M24_structural-domain. IPR001131. Peptidase_M24B_aminopep-P_CS. [Graphical view]
Pfam	PF01321. Creatinase_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP1_PODAN

Accession

Primary (citable) accession number: B2AWV6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	May 20, 2008
Last modified:	March 6, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program