Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Carboxypeptidase Y homolog A

Gene

CPYA

Organism
Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).By similarity

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei278PROSITE-ProRule annotation1
Active sitei470PROSITE-ProRule annotation1
Active sitei529PROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS10.001

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:CPYA
Ordered Locus Names:Pa_7_6790
ORF Names:PODANS_7_6790
OrganismiPodospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
Taxonomic identifieri515849 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesLasiosphaeriaceaePodospora
Proteomesi
  • UP000001197 Componenti: Chromosome 7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
PropeptideiPRO_000040747218 – 137By similarityAdd BLAST120
ChainiPRO_0000407473138 – 554Carboxypeptidase Y homolog AAdd BLAST417

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi191 ↔ 431By similarity
Glycosylationi222N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi325 ↔ 339By similarity
Disulfide bondi349 ↔ 372By similarity
Disulfide bondi356 ↔ 365By similarity
Disulfide bondi394 ↔ 401By similarity
Glycosylationi518N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PRIDEiB2AWD5

Interactioni

Protein-protein interaction databases

STRINGi515849.XP_001908036.1

Structurei

3D structure databases

ProteinModelPortaliB2AWD5
SMRiB2AWD5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1282 Eukaryota
COG2939 LUCA
KOiK13289
OrthoDBiEOG092C1EU7

Family and domain databases

Gene3Di3.40.50.1820, 2 hits
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
IPR008442 Propeptide_carboxypepY
IPR018202 Ser_caboxypep_ser_AS
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF05388 Carbpep_Y_N, 1 hit
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00131 CARBOXYPEPT_SER_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B2AWD5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVAASTVLL GVASAASFQQ QTQHVLSSGY ERAQAGMKPL AEQFVDAAGK
60 70 80 90 100
PIANIEEAFH GMTAEVKALW DEIKLLVPES AFNHSNWFTK PKPARRRHDW
110 120 130 140 150
DHVVKGADVQ KLWVQGESGE DHRQVDGKLA DFNLRVKAVD PSKLGVDKVK
160 170 180 190 200
QYSGYLDDEA NDKHLFYWFF ESRNDPKNDP VVLWLNGGPG CSSLTGLFLE
210 220 230 240 250
LGPSSIDKKL KVVNNEFSWN NNASVIFLDQ PVNVGYSYSG NSVSNTIAAG
260 270 280 290 300
KDVYALLSLF FHQFPEYAKQ DFHIAGESYA GHYIPVFASE ILSHKNRNIN
310 320 330 340 350
LKSILIGNGL TDGLTQYEHY RPMACGKGGY PAVLDESECR SMDNALPRCQ
360 370 380 390 400
SLIQNCYDSG SVWSCVPASI YCNNALIGPY QRTGQNVYDI RGKCEDSSNL
410 420 430 440 450
CYSALGWISD YLNQQDVMDA LGVEVSGYES CNFDINRNFL FQGDWMQPFH
460 470 480 490 500
RLVPNILKEI PVLIYAGDAD YICNWLGNQA WTEALEWPGK KNFNKASIKD
510 520 530 540 550
LKLAGAEKEY GKVKASGNFT FMQVYQAGHM VPMDQPENSL DFLNRWLGGE

WFAK
Length:554
Mass (Da):61,984
Last modified:May 20, 2008 - v1
Checksum:i7CD452763862547D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU633900 Genomic DNA Translation: CAP68709.1
FO904942 Genomic DNA Translation: CDP32179.1
RefSeqiXP_001908036.1, XM_001908001.1

Genome annotation databases

EnsemblFungiiCAP68709; CAP68709; PODANS_7_6790
GeneIDi6192366
KEGGipan:PODANSg5071

Similar proteinsi

Entry informationi

Entry nameiCBPYA_PODAN
AccessioniPrimary (citable) accession number: B2AWD5
Secondary accession number(s): A0A090CWP9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: May 20, 2008
Last modified: May 23, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health