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B2AWD5

- CBPYA_PODAN

UniProt

B2AWD5 - CBPYA_PODAN

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Protein

Carboxypeptidase Y homolog A

Gene
CPYA, PODANS_7_6790
Organism
Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei278 – 2781 By similarity
Active sitei470 – 4701 By similarity
Active sitei529 – 5291 By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS10.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:CPYA
Ordered Locus Names:PODANS_7_6790
OrganismiPodospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
Taxonomic identifieri515849 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesLasiosphaeriaceaePodospora
ProteomesiUP000001197: Chromosome 7

Subcellular locationi

Vacuole By similarity

GO - Cellular componenti

  1. vacuole Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed predictionAdd
BLAST
Propeptidei18 – 137120 By similarityPRO_0000407472Add
BLAST
Chaini138 – 554417Carboxypeptidase Y homolog APRO_0000407473Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi191 ↔ 431 By similarity
Glycosylationi222 – 2221N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi325 ↔ 339 By similarity
Disulfide bondi349 ↔ 372 By similarity
Disulfide bondi356 ↔ 365 By similarity
Disulfide bondi394 ↔ 401 By similarity
Glycosylationi518 – 5181N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Structurei

3D structure databases

ProteinModelPortaliB2AWD5.
SMRiB2AWD5. Positions 137-549.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal

Phylogenomic databases

KOiK13289.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B2AWD5-1 [UniParc]FASTAAdd to Basket

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MRVAASTVLL GVASAASFQQ QTQHVLSSGY ERAQAGMKPL AEQFVDAAGK    50
PIANIEEAFH GMTAEVKALW DEIKLLVPES AFNHSNWFTK PKPARRRHDW 100
DHVVKGADVQ KLWVQGESGE DHRQVDGKLA DFNLRVKAVD PSKLGVDKVK 150
QYSGYLDDEA NDKHLFYWFF ESRNDPKNDP VVLWLNGGPG CSSLTGLFLE 200
LGPSSIDKKL KVVNNEFSWN NNASVIFLDQ PVNVGYSYSG NSVSNTIAAG 250
KDVYALLSLF FHQFPEYAKQ DFHIAGESYA GHYIPVFASE ILSHKNRNIN 300
LKSILIGNGL TDGLTQYEHY RPMACGKGGY PAVLDESECR SMDNALPRCQ 350
SLIQNCYDSG SVWSCVPASI YCNNALIGPY QRTGQNVYDI RGKCEDSSNL 400
CYSALGWISD YLNQQDVMDA LGVEVSGYES CNFDINRNFL FQGDWMQPFH 450
RLVPNILKEI PVLIYAGDAD YICNWLGNQA WTEALEWPGK KNFNKASIKD 500
LKLAGAEKEY GKVKASGNFT FMQVYQAGHM VPMDQPENSL DFLNRWLGGE 550
WFAK 554
Length:554
Mass (Da):61,984
Last modified:May 20, 2008 - v1
Checksum:i7CD452763862547D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU633900 Genomic DNA. Translation: CAP68709.1.
RefSeqiXP_001908036.1. XM_001908001.1.

Genome annotation databases

GeneIDi6192366.
KEGGipan:PODANSg5071.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU633900 Genomic DNA. Translation: CAP68709.1 .
RefSeqi XP_001908036.1. XM_001908001.1.

3D structure databases

ProteinModelPortali B2AWD5.
SMRi B2AWD5. Positions 137-549.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 6192366.
KEGGi pan:PODANSg5071.

Phylogenomic databases

KOi K13289.

Family and domain databases

Gene3Di 3.40.50.1820. 2 hits.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S / ATCC MYA-4624 / DSM 980 / FGSC 10383.

Entry informationi

Entry nameiCBPYA_PODAN
AccessioniPrimary (citable) accession number: B2AWD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: May 20, 2008
Last modified: June 11, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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