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B2AWD5

- CBPYA_PODAN

UniProt

B2AWD5 - CBPYA_PODAN

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Protein

Carboxypeptidase Y homolog A

Gene

CPYA

Organism
Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).By similarity

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei278 – 2781PROSITE-ProRule annotation
Active sitei470 – 4701PROSITE-ProRule annotation
Active sitei529 – 5291PROSITE-ProRule annotation

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS10.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:CPYA
Ordered Locus Names:PODANS_7_6790
OrganismiPodospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
Taxonomic identifieri515849 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesLasiosphaeriaceaePodospora
ProteomesiUP000001197: Chromosome 7

Subcellular locationi

Vacuole By similarity

GO - Cellular componenti

  1. vacuole Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Propeptidei18 – 137120By similarityPRO_0000407472Add
BLAST
Chaini138 – 554417Carboxypeptidase Y homolog APRO_0000407473Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi191 ↔ 431By similarity
Glycosylationi222 – 2221N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi325 ↔ 339By similarity
Disulfide bondi349 ↔ 372By similarity
Disulfide bondi356 ↔ 365By similarity
Disulfide bondi394 ↔ 401By similarity
Glycosylationi518 – 5181N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Structurei

3D structure databases

ProteinModelPortaliB2AWD5.
SMRiB2AWD5. Positions 137-549.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

KOiK13289.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B2AWD5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRVAASTVLL GVASAASFQQ QTQHVLSSGY ERAQAGMKPL AEQFVDAAGK
60 70 80 90 100
PIANIEEAFH GMTAEVKALW DEIKLLVPES AFNHSNWFTK PKPARRRHDW
110 120 130 140 150
DHVVKGADVQ KLWVQGESGE DHRQVDGKLA DFNLRVKAVD PSKLGVDKVK
160 170 180 190 200
QYSGYLDDEA NDKHLFYWFF ESRNDPKNDP VVLWLNGGPG CSSLTGLFLE
210 220 230 240 250
LGPSSIDKKL KVVNNEFSWN NNASVIFLDQ PVNVGYSYSG NSVSNTIAAG
260 270 280 290 300
KDVYALLSLF FHQFPEYAKQ DFHIAGESYA GHYIPVFASE ILSHKNRNIN
310 320 330 340 350
LKSILIGNGL TDGLTQYEHY RPMACGKGGY PAVLDESECR SMDNALPRCQ
360 370 380 390 400
SLIQNCYDSG SVWSCVPASI YCNNALIGPY QRTGQNVYDI RGKCEDSSNL
410 420 430 440 450
CYSALGWISD YLNQQDVMDA LGVEVSGYES CNFDINRNFL FQGDWMQPFH
460 470 480 490 500
RLVPNILKEI PVLIYAGDAD YICNWLGNQA WTEALEWPGK KNFNKASIKD
510 520 530 540 550
LKLAGAEKEY GKVKASGNFT FMQVYQAGHM VPMDQPENSL DFLNRWLGGE

WFAK
Length:554
Mass (Da):61,984
Last modified:May 20, 2008 - v1
Checksum:i7CD452763862547D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU633900 Genomic DNA. Translation: CAP68709.1.
RefSeqiXP_001908036.1. XM_001908001.1.

Genome annotation databases

GeneIDi6192366.
KEGGipan:PODANSg5071.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU633900 Genomic DNA. Translation: CAP68709.1 .
RefSeqi XP_001908036.1. XM_001908001.1.

3D structure databases

ProteinModelPortali B2AWD5.
SMRi B2AWD5. Positions 137-549.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 6192366.
KEGGi pan:PODANSg5071.

Phylogenomic databases

KOi K13289.

Family and domain databases

Gene3Di 3.40.50.1820. 2 hits.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S / ATCC MYA-4624 / DSM 980 / FGSC 10383.

Entry informationi

Entry nameiCBPYA_PODAN
AccessioniPrimary (citable) accession number: B2AWD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: May 20, 2008
Last modified: October 29, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3