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Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene

PODANS_7_6450

Organism
Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei397 – 3971S-adenosyl-L-methionineUniRule annotation

GO - Molecular functioni

  1. histone methyltransferase activity (H3-K79 specific) Source: InterPro

GO - Biological processi

  1. chromatin silencing at telomere Source: InterPro
  2. DNA damage checkpoint Source: InterPro
  3. DNA repair Source: InterPro
  4. regulation of cell cycle Source: InterPro
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Alternative name(s):
Histone H3-K79 methyltransferaseUniRule annotation
Gene namesi
ORF Names:PODANS_7_6450Imported
OrganismiPodospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)Imported
Taxonomic identifieri515849 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesLasiosphaeriaceaePodospora
ProteomesiUP000001197: Chromosome 7

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni348 – 3514S-adenosyl-L-methionine bindingUniRule annotation
Regioni371 – 38010S-adenosyl-L-methionine bindingUniRule annotation
Regioni433 – 4342S-adenosyl-L-methionine bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.UniRule annotation

Phylogenomic databases

KOiK11427.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR021162. Dot1.
IPR025789. DOT1_dom.
IPR013110. DOT1_dom_Pfam.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
PIRSFiPIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2AWA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIFNQKSKF KVKTEVRAVK KTLPEKPKPK PTSAPPSTSR IPSSVRASPS
60 70 80 90 100
TTSTLRASPL PPSARKSQIG SSRYLDPSSA LKAPSSSTSS NSRKRPRASH
110 120 130 140 150
SPASPSFDSD SDSDSASDDD WQDQLDPRKR LKRLEQLRRH DPNRRVRHPK
160 170 180 190 200
MWKGDRESEG ELLPIIHAVE VASLSEKCQP VMGLSRDEVG VRLRYPGSNH
210 220 230 240 250
REKYACSILM STFYNCHLLF STKVYELVKG KDKIEGAQDI LTVVRHVASI
260 270 280 290 300
YLSEEEARPF LDQNSGIYRR LERCKNLNDG KGFKEALKEY SESLFALQRK
310 320 330 340 350
GVIAKNLENM RGVPQELVAF ILDQVYDRTV APKVELLAKY ENGTDNVYGE
360 370 380 390 400
LLHPFISDIF ERTQLTSDMV FVDLGSGVGN VVLQAALEIG CESWGCEMME
410 420 430 440 450
NACNLADAQK REFAARCRLW GVAPGKVHLE RGDFRKNEPI LESLKRADVV
460 470 480 490 500
LVNNQAFTSQ LNDNLVNMFL DLKIGCKIVS LKTFVHDNKL AENDVASSIL
510 520
DVEHLTYPEE YVSWTGAAGT YCISTRK
Length:527
Mass (Da):59,069
Last modified:May 20, 2008 - v1
Checksum:iD8294BDF1C4B5CC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU633900 Genomic DNA. Translation: CAP68674.1.
RefSeqiXP_001908001.1. XM_001907966.1.

Genome annotation databases

GeneIDi6192592.
KEGGipan:PODANSg5036.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU633900 Genomic DNA. Translation: CAP68674.1.
RefSeqiXP_001908001.1. XM_001907966.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi6192592.
KEGGipan:PODANSg5036.

Phylogenomic databases

KOiK11427.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR021162. Dot1.
IPR025789. DOT1_dom.
IPR013110. DOT1_dom_Pfam.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
PIRSFiPIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S / ATCC MYA-4624 / DSM 980 / FGSC 10383Imported.

Entry informationi

Entry nameiB2AWA0_PODAN
AccessioniPrimary (citable) accession number: B2AWA0
Entry historyi
Integrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: March 4, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.