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B2AWA0

- B2AWA0_PODAN

UniProt

B2AWA0 - B2AWA0_PODAN

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Protein
Histone-lysine N-methyltransferase, H3 lysine-79 specific
Gene
PODANS_7_6450
Organism
Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei397 – 3971S-adenosyl-L-methionine By similarityUniRule annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Alternative name(s):
Histone H3-K79 methyltransferase
Gene namesi
ORF Names:PODANS_7_6450Imported
OrganismiPodospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)Imported
Taxonomic identifieri515849 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesLasiosphaeriaceaePodospora
ProteomesiUP000001197: Chromosome 7

Subcellular locationi

Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB2AWA0.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni348 – 3514S-adenosyl-L-methionine binding By similarityUniRule annotation
Regioni371 – 38010S-adenosyl-L-methionine binding By similarityUniRule annotation
Regioni433 – 4342S-adenosyl-L-methionine binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK11427.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021162. Histone_H3-K79_MeTrfase_fungi.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
PIRSFiPIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2AWA0-1 [UniParc]FASTAAdd to Basket

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MSIFNQKSKF KVKTEVRAVK KTLPEKPKPK PTSAPPSTSR IPSSVRASPS    50
TTSTLRASPL PPSARKSQIG SSRYLDPSSA LKAPSSSTSS NSRKRPRASH 100
SPASPSFDSD SDSDSASDDD WQDQLDPRKR LKRLEQLRRH DPNRRVRHPK 150
MWKGDRESEG ELLPIIHAVE VASLSEKCQP VMGLSRDEVG VRLRYPGSNH 200
REKYACSILM STFYNCHLLF STKVYELVKG KDKIEGAQDI LTVVRHVASI 250
YLSEEEARPF LDQNSGIYRR LERCKNLNDG KGFKEALKEY SESLFALQRK 300
GVIAKNLENM RGVPQELVAF ILDQVYDRTV APKVELLAKY ENGTDNVYGE 350
LLHPFISDIF ERTQLTSDMV FVDLGSGVGN VVLQAALEIG CESWGCEMME 400
NACNLADAQK REFAARCRLW GVAPGKVHLE RGDFRKNEPI LESLKRADVV 450
LVNNQAFTSQ LNDNLVNMFL DLKIGCKIVS LKTFVHDNKL AENDVASSIL 500
DVEHLTYPEE YVSWTGAAGT YCISTRK 527
Length:527
Mass (Da):59,069
Last modified:May 20, 2008 - v1
Checksum:iD8294BDF1C4B5CC5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU633900 Genomic DNA. Translation: CAP68674.1.
RefSeqiXP_001908001.1. XM_001907966.1.

Genome annotation databases

GeneIDi6192592.
KEGGipan:PODANSg5036.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU633900 Genomic DNA. Translation: CAP68674.1 .
RefSeqi XP_001908001.1. XM_001907966.1.

3D structure databases

ProteinModelPortali B2AWA0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 6192592.
KEGGi pan:PODANSg5036.

Phylogenomic databases

KOi K11427.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021162. Histone_H3-K79_MeTrfase_fungi.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF08123. DOT1. 1 hit.
[Graphical view ]
PIRSFi PIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51569. DOT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S / ATCC MYA-4624 / DSM 980 / FGSC 10383.

Entry informationi

Entry nameiB2AWA0_PODAN
AccessioniPrimary (citable) accession number: B2AWA0
Entry historyi
Integrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: June 11, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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