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Protein

Bifunctional lycopene cyclase/phytoene synthase

Gene

Pa_1_15240

Organism
Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Bifunctional enzyme that catalyzes the reactions from geranylgeranyl diphosphate to phytoene (phytoene synthase) and lycopene to beta-carotene via the intermediate gamma-carotene (lycopene cyclase).By similarity

Catalytic activityi

Carotenoid psi-end group = carotenoid beta-end group.
2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.

Pathwayi: beta-carotene biosynthesis

This protein is involved in the pathway beta-carotene biosynthesis, which is part of Carotenoid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway beta-carotene biosynthesis and in Carotenoid biosynthesis.

Pathwayi: phytoene biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes all-trans-phytoene from geranylgeranyl diphosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Bifunctional lycopene cyclase/phytoene synthase (Pa_1_15240)
This subpathway is part of the pathway phytoene biosynthesis, which is itself part of Carotenoid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes all-trans-phytoene from geranylgeranyl diphosphate, the pathway phytoene biosynthesis and in Carotenoid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Multifunctional enzyme, Transferase
Biological processCarotenoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00799; UER00773
UPA00802

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional lycopene cyclase/phytoene synthase
Including the following 2 domains:
Lycopene beta-cyclase (EC:5.5.1.19)
Alternative name(s):
Lycopene cyclase
Phytoene synthase (EC:2.5.1.32)
Gene namesi
Ordered Locus Names:Pa_1_15240
ORF Names:PODANS_1_15240
OrganismiPodospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
Taxonomic identifieri515849 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesLasiosphaeriaceaePodospora
Proteomesi
  • UP000001197 Componenti: Chromosome 1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Transmembranei31 – 51HelicalSequence analysisAdd BLAST21
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Transmembranei117 – 136HelicalSequence analysisAdd BLAST20
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Transmembranei169 – 189HelicalSequence analysisAdd BLAST21
Transmembranei231 – 251HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004092411 – 593Bifunctional lycopene cyclase/phytoene synthaseAdd BLAST593

Proteomic databases

PRIDEiB2ATB0

Interactioni

Protein-protein interaction databases

STRINGi515849.XP_001906962.1

Structurei

3D structure databases

ProteinModelPortaliB2ATB0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 242Lycopene beta-cyclaseAdd BLAST242
Regioni249 – 593Phytoene synthaseAdd BLAST345

Sequence similaritiesi

In the N-terminal section; belongs to the lycopene beta-cyclase family.Curated
In the C-terminal section; belongs to the phytoene/squalene synthase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFST Eukaryota
COG1562 LUCA
KOiK17841
OrthoDBiEOG092C1GQ8

Family and domain databases

CDDicd00683 Trans_IPPS_HH, 1 hit
Gene3Di1.10.600.10, 1 hit
InterProiView protein in InterPro
IPR008949 Isoprenoid_synthase_dom_sf
IPR017825 Lycopene_cyclase_dom
IPR002060 Squ/phyt_synthse
IPR019845 Squalene/phytoene_synthase_CS
IPR033904 Trans_IPPS_HH
PfamiView protein in Pfam
PF00494 SQS_PSY, 1 hit
SUPFAMiSSF48576 SSF48576, 1 hit
TIGRFAMsiTIGR03462 CarR_dom_SF, 2 hits
PROSITEiView protein in PROSITE
PS01045 SQUALEN_PHYTOEN_SYN_2, 1 hit

Sequencei

Sequence statusi: Complete.

B2ATB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYDYALVHL KYTIPLAALL TVIAYPIFHR IHFLQIGSLI VVSFLATLPW
60 70 80 90 100
DSYLIRSNIW TYPPDAIIGP RLYGIPIEEL FFFVIQTYIT SLFYILLSKP
110 120 130 140 150
LFHPLYLSTQ RNPPQRIARG KVIGQGILVA LTLYGVHQIR TGGPGTYLGL
160 170 180 190 200
ILAWAFPFAL LTFTVAGRFI LTLPLTSTVV PIIIPTVYLW LVDELALGRG
210 220 230 240 250
TWAIESGTKL GWCLFGVLDI EEATFFLATN ILIVFGMAVF DQYLAIIFAF
260 270 280 290 300
PHLFPKVPRS PTPLMLVQSR FSNTKQYDLE RIAGLSDAVT RLKAKSRSFY
310 320 330 340 350
LANSLFTGRL RIDLILLYSF CRLADDLVDD STSRTEVKSW TTKLYKFLDL
360 370 380 390 400
HYKSDVKANK ARINDYIDEA FPPEAKSALK YLPATILPSQ PLYQLIEGFE
410 420 430 440 450
LDSQFSFHDS SESAKYPIVD EDKLNYYGQC VAGTVGELCV ALIIEHCEPE
460 470 480 490 500
MPDERKKMLM SVSRTMGVAL QYVNIARDIV VDAEMGRVYL PTTWLKEEGL
510 520 530 540 550
TPEDVVAHPR GKHVENLRRR LLSEAFKLYD EARPKMNGIP KEARGPMIGA
560 570 580 590
VETYMEIGRV LRELEGGVEL ERGKATVPGG RRLKTVLKAL FSA
Length:593
Mass (Da):66,914
Last modified:May 20, 2008 - v1
Checksum:iB7430708736FDB86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU633899 Genomic DNA Translation: CAP67633.1
FO904936 Genomic DNA Translation: CDP23892.1
RefSeqiXP_001906962.1, XM_001906927.1

Genome annotation databases

EnsemblFungiiCAP67633; CAP67633; PODANS_1_15240
GeneIDi6191495
KEGGipan:PODANSg3995

Similar proteinsi

Entry informationi

Entry nameiLCPS_PODAN
AccessioniPrimary (citable) accession number: B2ATB0
Secondary accession number(s): A0A090CF73
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: May 20, 2008
Last modified: May 23, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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