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B2ATB0

- LCPS_PODAN

UniProt

B2ATB0 - LCPS_PODAN

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Protein

Bifunctional lycopene cyclase/phytoene synthase

Gene
PODANS_1_15240
Organism
Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Bifunctional enzyme that catalyzes the reactions from geranylgeranyl diphosphate to phytoene (phytoene synthase) and lycopene to beta-carotene via the intermediate gamma-carotene (lycopene cyclase) By similarity.

Catalytic activityi

Carotenoid psi-end group = carotenoid beta-end group.
2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.

Pathwayi

GO - Molecular functioni

  1. geranylgeranyl-diphosphate geranylgeranyltransferase activity Source: UniProtKB-EC
  2. intramolecular lyase activity Source: InterPro

GO - Biological processi

  1. carotenoid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Transferase

Keywords - Biological processi

Carotenoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00799; UER00773.
UPA00802.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional lycopene cyclase/phytoene synthase
Including the following 2 domains:
Lycopene beta-cyclase (EC:5.5.1.19)
Alternative name(s):
Lycopene cyclase
Phytoene synthase (EC:2.5.1.32)
Gene namesi
Ordered Locus Names:PODANS_1_15240
OrganismiPodospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
Taxonomic identifieri515849 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesLasiosphaeriaceaePodospora
ProteomesiUP000001197: Chromosome 1

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2821Helical; Reviewed predictionAdd
BLAST
Transmembranei31 – 5121Helical; Reviewed predictionAdd
BLAST
Transmembranei77 – 9721Helical; Reviewed predictionAdd
BLAST
Transmembranei117 – 13620Helical; Reviewed predictionAdd
BLAST
Transmembranei147 – 16721Helical; Reviewed predictionAdd
BLAST
Transmembranei169 – 18921Helical; Reviewed predictionAdd
BLAST
Transmembranei231 – 25121Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 593593Bifunctional lycopene cyclase/phytoene synthasePRO_0000409241Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliB2ATB0.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 242242Lycopene beta-cyclaseAdd
BLAST
Regioni249 – 593345Phytoene synthaseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the lycopene beta-cyclase family.
In the C-terminal section; belongs to the phytoene/squalene synthase family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK17841.

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR017825. Lycopene_cyclase_dom.
IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamiPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
TIGRFAMsiTIGR03462. CarR_dom_SF. 2 hits.
PROSITEiPS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2ATB0-1 [UniParc]FASTAAdd to Basket

« Hide

MAYDYALVHL KYTIPLAALL TVIAYPIFHR IHFLQIGSLI VVSFLATLPW    50
DSYLIRSNIW TYPPDAIIGP RLYGIPIEEL FFFVIQTYIT SLFYILLSKP 100
LFHPLYLSTQ RNPPQRIARG KVIGQGILVA LTLYGVHQIR TGGPGTYLGL 150
ILAWAFPFAL LTFTVAGRFI LTLPLTSTVV PIIIPTVYLW LVDELALGRG 200
TWAIESGTKL GWCLFGVLDI EEATFFLATN ILIVFGMAVF DQYLAIIFAF 250
PHLFPKVPRS PTPLMLVQSR FSNTKQYDLE RIAGLSDAVT RLKAKSRSFY 300
LANSLFTGRL RIDLILLYSF CRLADDLVDD STSRTEVKSW TTKLYKFLDL 350
HYKSDVKANK ARINDYIDEA FPPEAKSALK YLPATILPSQ PLYQLIEGFE 400
LDSQFSFHDS SESAKYPIVD EDKLNYYGQC VAGTVGELCV ALIIEHCEPE 450
MPDERKKMLM SVSRTMGVAL QYVNIARDIV VDAEMGRVYL PTTWLKEEGL 500
TPEDVVAHPR GKHVENLRRR LLSEAFKLYD EARPKMNGIP KEARGPMIGA 550
VETYMEIGRV LRELEGGVEL ERGKATVPGG RRLKTVLKAL FSA 593
Length:593
Mass (Da):66,914
Last modified:May 20, 2008 - v1
Checksum:iB7430708736FDB86
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU633899 Genomic DNA. Translation: CAP67633.1.
RefSeqiXP_001906962.1. XM_001906927.1.

Genome annotation databases

GeneIDi6191495.
KEGGipan:PODANSg3995.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU633899 Genomic DNA. Translation: CAP67633.1 .
RefSeqi XP_001906962.1. XM_001906927.1.

3D structure databases

ProteinModelPortali B2ATB0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 6191495.
KEGGi pan:PODANSg3995.

Phylogenomic databases

KOi K17841.

Enzyme and pathway databases

UniPathwayi UPA00799 ; UER00773 .
UPA00802 .

Family and domain databases

Gene3Di 1.10.600.10. 1 hit.
InterProi IPR017825. Lycopene_cyclase_dom.
IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view ]
Pfami PF00494. SQS_PSY. 1 hit.
[Graphical view ]
SUPFAMi SSF48576. SSF48576. 1 hit.
TIGRFAMsi TIGR03462. CarR_dom_SF. 2 hits.
PROSITEi PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S / ATCC MYA-4624 / DSM 980 / FGSC 10383.

Entry informationi

Entry nameiLCPS_PODAN
AccessioniPrimary (citable) accession number: B2ATB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: May 20, 2008
Last modified: February 19, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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