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Protein

Bifunctional lycopene cyclase/phytoene synthase

Gene

PODANS_1_15240

Organism
Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme that catalyzes the reactions from geranylgeranyl diphosphate to phytoene (phytoene synthase) and lycopene to beta-carotene via the intermediate gamma-carotene (lycopene cyclase).By similarity

Catalytic activityi

Carotenoid psi-end group = carotenoid beta-end group.
2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.

Pathway: beta-carotene biosynthesis

This protein is involved in the pathway beta-carotene biosynthesis, which is part of Carotenoid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway beta-carotene biosynthesis and in Carotenoid biosynthesis.

Pathway: phytoene biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes all-trans-phytoene from geranylgeranyl diphosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Bifunctional lycopene cyclase/phytoene synthase (PODANS_1_15240)
This subpathway is part of the pathway phytoene biosynthesis, which is itself part of Carotenoid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes all-trans-phytoene from geranylgeranyl diphosphate, the pathway phytoene biosynthesis and in Carotenoid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Transferase

Keywords - Biological processi

Carotenoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00799; UER00773.
UPA00802.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional lycopene cyclase/phytoene synthase
Including the following 2 domains:
Lycopene beta-cyclase (EC:5.5.1.19)
Alternative name(s):
Lycopene cyclase
Phytoene synthase (EC:2.5.1.32)
Gene namesi
Ordered Locus Names:PODANS_1_15240
OrganismiPodospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
Taxonomic identifieri515849 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesLasiosphaeriaceaePodospora
ProteomesiUP000001197 Componenti: Chromosome 1

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2821HelicalSequence AnalysisAdd
BLAST
Transmembranei31 – 5121HelicalSequence AnalysisAdd
BLAST
Transmembranei77 – 9721HelicalSequence AnalysisAdd
BLAST
Transmembranei117 – 13620HelicalSequence AnalysisAdd
BLAST
Transmembranei147 – 16721HelicalSequence AnalysisAdd
BLAST
Transmembranei169 – 18921HelicalSequence AnalysisAdd
BLAST
Transmembranei231 – 25121HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 593593Bifunctional lycopene cyclase/phytoene synthasePRO_0000409241Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi515849.XP_001906962.1.

Structurei

3D structure databases

ProteinModelPortaliB2ATB0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 242242Lycopene beta-cyclaseAdd
BLAST
Regioni249 – 593345Phytoene synthaseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the lycopene beta-cyclase family.Curated
In the C-terminal section; belongs to the phytoene/squalene synthase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK17841.

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR008949. Isoprenoid_synthase_dom.
IPR017825. Lycopene_cyclase_dom.
IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
[Graphical view]
PfamiPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
TIGRFAMsiTIGR03462. CarR_dom_SF. 2 hits.
PROSITEiPS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2ATB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYDYALVHL KYTIPLAALL TVIAYPIFHR IHFLQIGSLI VVSFLATLPW
60 70 80 90 100
DSYLIRSNIW TYPPDAIIGP RLYGIPIEEL FFFVIQTYIT SLFYILLSKP
110 120 130 140 150
LFHPLYLSTQ RNPPQRIARG KVIGQGILVA LTLYGVHQIR TGGPGTYLGL
160 170 180 190 200
ILAWAFPFAL LTFTVAGRFI LTLPLTSTVV PIIIPTVYLW LVDELALGRG
210 220 230 240 250
TWAIESGTKL GWCLFGVLDI EEATFFLATN ILIVFGMAVF DQYLAIIFAF
260 270 280 290 300
PHLFPKVPRS PTPLMLVQSR FSNTKQYDLE RIAGLSDAVT RLKAKSRSFY
310 320 330 340 350
LANSLFTGRL RIDLILLYSF CRLADDLVDD STSRTEVKSW TTKLYKFLDL
360 370 380 390 400
HYKSDVKANK ARINDYIDEA FPPEAKSALK YLPATILPSQ PLYQLIEGFE
410 420 430 440 450
LDSQFSFHDS SESAKYPIVD EDKLNYYGQC VAGTVGELCV ALIIEHCEPE
460 470 480 490 500
MPDERKKMLM SVSRTMGVAL QYVNIARDIV VDAEMGRVYL PTTWLKEEGL
510 520 530 540 550
TPEDVVAHPR GKHVENLRRR LLSEAFKLYD EARPKMNGIP KEARGPMIGA
560 570 580 590
VETYMEIGRV LRELEGGVEL ERGKATVPGG RRLKTVLKAL FSA
Length:593
Mass (Da):66,914
Last modified:May 20, 2008 - v1
Checksum:iB7430708736FDB86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU633899 Genomic DNA. Translation: CAP67633.1.
RefSeqiXP_001906962.1. XM_001906927.1.

Genome annotation databases

GeneIDi6191495.
KEGGipan:PODANSg3995.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU633899 Genomic DNA. Translation: CAP67633.1.
RefSeqiXP_001906962.1. XM_001906927.1.

3D structure databases

ProteinModelPortaliB2ATB0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi515849.XP_001906962.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi6191495.
KEGGipan:PODANSg3995.

Phylogenomic databases

KOiK17841.

Enzyme and pathway databases

UniPathwayiUPA00799; UER00773.
UPA00802.

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR008949. Isoprenoid_synthase_dom.
IPR017825. Lycopene_cyclase_dom.
IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
[Graphical view]
PfamiPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
TIGRFAMsiTIGR03462. CarR_dom_SF. 2 hits.
PROSITEiPS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S / ATCC MYA-4624 / DSM 980 / FGSC 10383.

Entry informationi

Entry nameiLCPS_PODAN
AccessioniPrimary (citable) accession number: B2ATB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: May 20, 2008
Last modified: June 24, 2015
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.