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B2ATB0 (LCPS_PODAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional lycopene cyclase/phytoene synthase

Including the following 2 domains:

  1. Lycopene beta-cyclase
    EC=5.5.1.19
    Alternative name(s):
    Lycopene cyclase
  2. Phytoene synthase
    EC=2.5.1.32
Gene names
Ordered Locus Names:PODANS_1_15240
OrganismPodospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina) [Complete proteome]
Taxonomic identifier515849 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesLasiosphaeriaceaePodospora

Protein attributes

Sequence length593 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Bifunctional enzyme that catalyzes the reactions from geranylgeranyl diphosphate to phytoene (phytoene synthase) and lycopene to beta-carotene via the intermediate gamma-carotene (lycopene cyclase) By similarity.

Catalytic activity

Carotenoid psi-end group = carotenoid beta-end group.

2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.

Pathway

Carotenoid biosynthesis; beta-carotene biosynthesis.

Carotenoid biosynthesis; phytoene biosynthesis; all-trans-phytoene from geranylgeranyl diphosphate: step 1/1.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

In the N-terminal section; belongs to the lycopene beta-cyclase family.

In the C-terminal section; belongs to the phytoene/squalene synthase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 593593Bifunctional lycopene cyclase/phytoene synthase
PRO_0000409241

Regions

Transmembrane8 – 2821Helical; Potential
Transmembrane31 – 5121Helical; Potential
Transmembrane77 – 9721Helical; Potential
Transmembrane117 – 13620Helical; Potential
Transmembrane147 – 16721Helical; Potential
Transmembrane169 – 18921Helical; Potential
Transmembrane231 – 25121Helical; Potential
Region1 – 242242Lycopene beta-cyclase
Region249 – 593345Phytoene synthase

Sequences

Sequence LengthMass (Da)Tools
B2ATB0 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: B7430708736FDB86

FASTA59366,914
        10         20         30         40         50         60 
MAYDYALVHL KYTIPLAALL TVIAYPIFHR IHFLQIGSLI VVSFLATLPW DSYLIRSNIW 

        70         80         90        100        110        120 
TYPPDAIIGP RLYGIPIEEL FFFVIQTYIT SLFYILLSKP LFHPLYLSTQ RNPPQRIARG 

       130        140        150        160        170        180 
KVIGQGILVA LTLYGVHQIR TGGPGTYLGL ILAWAFPFAL LTFTVAGRFI LTLPLTSTVV 

       190        200        210        220        230        240 
PIIIPTVYLW LVDELALGRG TWAIESGTKL GWCLFGVLDI EEATFFLATN ILIVFGMAVF 

       250        260        270        280        290        300 
DQYLAIIFAF PHLFPKVPRS PTPLMLVQSR FSNTKQYDLE RIAGLSDAVT RLKAKSRSFY 

       310        320        330        340        350        360 
LANSLFTGRL RIDLILLYSF CRLADDLVDD STSRTEVKSW TTKLYKFLDL HYKSDVKANK 

       370        380        390        400        410        420 
ARINDYIDEA FPPEAKSALK YLPATILPSQ PLYQLIEGFE LDSQFSFHDS SESAKYPIVD 

       430        440        450        460        470        480 
EDKLNYYGQC VAGTVGELCV ALIIEHCEPE MPDERKKMLM SVSRTMGVAL QYVNIARDIV 

       490        500        510        520        530        540 
VDAEMGRVYL PTTWLKEEGL TPEDVVAHPR GKHVENLRRR LLSEAFKLYD EARPKMNGIP 

       550        560        570        580        590 
KEARGPMIGA VETYMEIGRV LRELEGGVEL ERGKATVPGG RRLKTVLKAL FSA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU633899 Genomic DNA. Translation: CAP67633.1.
RefSeqXP_001906962.1. XM_001906927.1.

3D structure databases

ProteinModelPortalB2ATB0.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6191495.
KEGGpan:PODANSg3995.

Phylogenomic databases

KOK17841.

Enzyme and pathway databases

UniPathwayUPA00799; UER00773.
UPA00802.

Family and domain databases

Gene3D1.10.600.10. 1 hit.
InterProIPR017825. Lycopene_cyclase_dom.
IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMSSF48576. SSF48576. 1 hit.
TIGRFAMsTIGR03462. CarR_dom_SF. 2 hits.
PROSITEPS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLCPS_PODAN
AccessionPrimary (citable) accession number: B2ATB0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: May 20, 2008
Last modified: February 19, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways