Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Catalase-peroxidase

Gene

katG

Organism
Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per monomer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei90 – 901Transition state stabilizerUniRule annotation
Active sitei94 – 941Proton acceptorUniRule annotation
Metal bindingi282 – 2821Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei5373. PanCP01.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:Pa_6_11240
ORF Names:PODANS_6_11240
OrganismiPodospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
Taxonomic identifieri515849 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesLasiosphaeriaceaePodospora
Proteomesi
  • UP000001197 Componenti: Chromosome 6

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 755755Catalase-peroxidasePRO_0000354110Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki93 ↔ 241Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-267)UniRule annotation
Cross-linki241 ↔ 267Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-93)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiB2ASU5.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi515849.XP_001906797.1.

Structurei

3D structure databases

ProteinModelPortaliB2ASU5.
SMRiB2ASU5. Positions 18-745.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG410IEWS. Eukaryota.
COG0376. LUCA.
KOiK03782.
OrthoDBiEOG092C0YTX.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2ASU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGECPVNHTK SANVAGGGTR NIDWWPNQLR LNILRQHTAA SDPFHKEFNY
60 70 80 90 100
AAAFKSLDYN ALKKDLTDLM TNSQDWWPAD FGHYGGLFIR MAWHSAGTYR
110 120 130 140 150
VFDGRGGGGQ GQQRFAPLNS WPDNVSLDKA RRLLWPIKQK YGNKISWADL
160 170 180 190 200
MLLTGNVALE SMGFKTFGFA GGRPDTWEAD ESAYWGGETT WLGNEARYAH
210 220 230 240 250
GQEGIAGKGI VSGDESKKNH TDIHNRDLES PLAAAHMGLI YVNPEGPDGN
260 270 280 290 300
PDPVAAARDI RVTFGRMAMD DEETVALIAG GHTFGKTHGA APADNVGAEP
310 320 330 340 350
EAASIEQQGF GWSNKYGSGK GPDTITSGLE VIWTKNPTKW TNQFFEYLFK
360 370 380 390 400
YEWELTKSPA GANQWVAKNA EPFIPDAYDP NKKHLPRMLT TDLSLRFDPG
410 420 430 440 450
FEKISRRFLE HTDQFADAFA RAWFKLLHRD MGPRSRWLGP EIPSEVLLWE
460 470 480 490 500
DPLPPLDHPV IDNNDIAAIK REILATGLAP QKLISTAWAS ASTFRGSDKR
510 520 530 540 550
GGANGARIRL APQKDWKVNN PAQLAEVLGA LEDVQKRFNE QATGGKKVSL
560 570 580 590 600
ADVIVLGGVA ALEQAAGVSV PFTPGRTDAS QEQTDVHSFE HLEPYADGFR
610 620 630 640 650
NYGHGNDRVK TEQYLVDRAH LLTLTAPELA VLVGGLRVLG ANYDGSDHGV
660 670 680 690 700
FTAQPGKLTN DFFVNLLDPN TEWTNVDGKG EVFEGKDRAT GQKKWTGTRA
710 720 730 740 750
DLIFGSHSEL RAIAEVYGSA DGQEKFVKDF VAAWDKVMNL DRFDLEQGAG

SSPKL
Length:755
Mass (Da):83,151
Last modified:May 20, 2008 - v1
Checksum:i1821E47DB46A0B9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU633898 Genomic DNA. Translation: CAP67468.1.
FO904941 Genomic DNA. Translation: CDP30334.1.
RefSeqiXP_001906797.1. XM_001906762.1.

Genome annotation databases

EnsemblFungiiCAP67468; CAP67468; PODANS_6_11240.
GeneIDi6191100.
KEGGipan:PODANSg3830.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU633898 Genomic DNA. Translation: CAP67468.1.
FO904941 Genomic DNA. Translation: CDP30334.1.
RefSeqiXP_001906797.1. XM_001906762.1.

3D structure databases

ProteinModelPortaliB2ASU5.
SMRiB2ASU5. Positions 18-745.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi515849.XP_001906797.1.

Protein family/group databases

PeroxiBasei5373. PanCP01.

Proteomic databases

PRIDEiB2ASU5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAP67468; CAP67468; PODANS_6_11240.
GeneIDi6191100.
KEGGipan:PODANSg3830.

Phylogenomic databases

eggNOGiENOG410IEWS. Eukaryota.
COG0376. LUCA.
KOiK03782.
OrthoDBiEOG092C0YTX.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_PODAN
AccessioniPrimary (citable) accession number: B2ASU5
Secondary accession number(s): A0A090CUI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: May 20, 2008
Last modified: September 7, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.