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B2AP14 (B2AP14_PODAN) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length474 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity. PIRNR PIRNR038800 HAMAP-Rule MF_03017

Catalytic activity

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine. PIRNR PIRNR038800 HAMAP-Rule MF_03017

L-kynurenine + H2O = anthranilate + L-alanine. PIRNR PIRNR038800 HAMAP-Rule MF_03017

Cofactor

Pyridoxal phosphate By similarity. PIRNR PIRNR038800 HAMAP-Rule MF_03017

Pathway

Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1. PIRNR PIRNR038800 HAMAP-Rule MF_03017

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3. PIRNR PIRNR038800 HAMAP-Rule MF_03017

Subunit structure

Homodimer By similarity. PIRNR PIRNR038800 HAMAP-Rule MF_03017

Subcellular location

Cytoplasm By similarity PIRNR PIRNR038800 HAMAP-Rule MF_03017.

Sequence similarities

Belongs to the kynureninase family. PIRNR PIRNR038800 HAMAP-Rule MF_03017

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region173 – 1764Pyridoxal phosphate binding By similarity HAMAP-Rule MF_03017

Sites

Binding site1451Pyridoxal phosphate; via amide nitrogen By similarity HAMAP-Rule MF_03017
Binding site1461Pyridoxal phosphate By similarity HAMAP-Rule MF_03017
Binding site2581Pyridoxal phosphate By similarity HAMAP-Rule MF_03017
Binding site2611Pyridoxal phosphate By similarity HAMAP-Rule MF_03017
Binding site2831Pyridoxal phosphate By similarity HAMAP-Rule MF_03017
Binding site3131Pyridoxal phosphate By similarity HAMAP-Rule MF_03017
Binding site3411Pyridoxal phosphate By similarity HAMAP-Rule MF_03017

Amino acid modifications

Modified residue2841N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_03017

Sequences

Sequence LengthMass (Da)Tools
B2AP14 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: DCB0CA4CB24A6003

FASTA47452,305
        10         20         30         40         50         60 
MDSLTAAFRS GQKPSFPAEA GTLEYAQSLD QQDKLGHLRK EFNIPTRTSL KKKALNGVSP 

        70         80         90        100        110        120 
GENDSEDEKS IYFVGNSLGA QPKAVRRALE SQLETWASIG VNGHFSTLEN SPLSSWQDLA 

       130        140        150        160        170        180 
ESCARKSVDL VGAAVPEEII YMNTLTANLH LMMASFYKPT AERDKVIIEW KPFPSDWYAI 

       190        200        210        220        230        240 
QSQIRHHNLS PSTSLIEIQP TPDLYLTTES ILATITEHAP STALVLLPGI QYYTGQLLDI 

       250        260        270        280        290        300 
KTITAHAHSL GIPCVGWDLA HAAGNVPLHL HDWNVDFAVW CTYKYINAGP GSTAGLFLHQ 

       310        320        330        340        350        360 
KHHSKNLDRL EGWYGADKSV RFLMEKEFKP SKGASGWQLS NPSAIDLASV SAALGVFESV 

       370        380        390        400        410        420 
GERYMERLRG KAVVLTGYLE CLLEGLIRGG VGRKGEEQAF RIITPGNPLE RGTQLSLMLR 

       430        440        450        460        470 
EGILEGVSKV LAEEGVVCDA RKPDVIRVAP VPMYCRFEDV WRFVEIFKGA LARV 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU633873 Genomic DNA. Translation: CAP65719.1.
RefSeqXP_001905477.1. XM_001905442.1.

3D structure databases

ProteinModelPortalB2AP14.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6189648.
KEGGpan:PODANSg2503.

Phylogenomic databases

KOK01556.

Enzyme and pathway databases

UniPathwayUPA00253; UER00329.
UPA00334; UER00455.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPMF_01970. Kynureninase.
InterProIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERPTHR14084. PTHR14084. 1 hit.
PfamPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFPIRSF038800. KYNU. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
TIGRFAMsTIGR01814. kynureninase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB2AP14_PODAN
AccessionPrimary (citable) accession number: B2AP14
Entry history
Integrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: July 9, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)