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B2AND4 (MTLD_PODAN) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Mannitol-1-phosphate 5-dehydrogenase

Short name=M1PDH
Short name=MPD
Short name=MPDH
EC=1.1.1.17
Gene names
ORF Names:Pa_6_10260
OrganismPodospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina) [Complete proteome]
Taxonomic identifier515849 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesLasiosphaeriaceaePodospora

Protein attributes

Sequence length397 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NAD(H)-dependent interconversion of D-fructose 6-phosphate and D-mannitol 1-phosphate in the mannitol metabolic pathway By similarity.

Catalytic activity

D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH.

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the mannitol dehydrogenase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 397397Mannitol-1-phosphate 5-dehydrogenase
PRO_0000371535

Regions

Nucleotide binding9 – 2012NAD By similarity

Sites

Active site2201 By similarity

Sequences

Sequence LengthMass (Da)Tools
B2AND4 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: 1CA27B417CFEA4ED

FASTA39744,155
        10         20         30         40         50         60 
MERNTPKKAV HFGAGNIGRG FVACFLHESG YEVIFAEVND ATVSKLNTHK SYKVIEVGAE 

        70         80         90        100        110        120 
GTTEKTITNY RAINSRSNEA ALVEEIATAD VVTCSVGPNI LKFLAPVIAK GLAARSTDLT 

       130        140        150        160        170        180 
PAAVIACENA IGATDTLAEF IKSPENTNPA LLEDYDKRAT FANSAIDRIV PAQDPDAGLD 

       190        200        210        220        230        240 
VKLEKFYEWV VEKTPFKEWA VPDIKGIKWV DNLQPFIERK LYTVNTGHAT AAYYGYTRRK 

       250        260        270        280        290        300 
STVYDALQDK DIRDEVKNAL KETADLITEK HGIDEEEQKQ YVDKIVRRIS NPHLEDAVER 

       310        320        330        340        350        360 
VGRAPLRKLS RKERFIGPAA ELAENGKDCS ALLDAAEMAF RFQNVEGDDE SFELAKIMEE 

       370        380        390 
KKPEEVVQEV CGLQPSEKLY PQVVDIVKRV QADSNEE 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU633872 Genomic DNA. Translation: CAP65533.1.
RefSeqXP_003437448.1. XM_003437400.1.

3D structure databases

ProteinModelPortalB2AND4.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID11176499.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR023028. Mannitol_1_phos_5_DH.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
PfamPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSPR00084. MTLDHDRGNASE.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
PROSITEPS00974. MANNITOL_DHGENASE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTLD_PODAN
AccessionPrimary (citable) accession number: B2AND4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 20, 2008
Last modified: December 14, 2011
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families