Reviewed, UniProtKB/Swiss-Prot B2AND4 (MTLD_PODAN)

Names and origin

Protein names	Recommended name:     Mannitol-1-phosphate 5-dehydrogenase       Short name=M1PDH       Short name=MPDH       Short name=MPD     EC=1.1.1.17
Organism	Podospora anserina
Taxonomic identifier	5145 [NCBI]
Taxonomic lineage	Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Lasiosphaeriaceae › Podospora

Protein attributes

Sequence length	397 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NAD(H)-dependent interconversion of D-fructose 6-phosphate and D-mannitol 1-phosphate in the mannitol metabolic pathway By similarity.
Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH.
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 397	397	Mannitol-1-phosphate 5-dehydrogenase		PRO_0000371535
Regions
	Nucleotide binding	9 – 20	12	NAD By similarity
Sites
	Active site	220	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B2AND4-1 [UniParc]. Last modified May 20, 2008. Version 1. Checksum: 1CA27B417CFEA4ED	FASTA	397	44,155
	10 20 30 40 50 60 MERNTPKKAV HFGAGNIGRG FVACFLHESG YEVIFAEVND ATVSKLNTHK SYKVIEVGAE 70 80 90 100 110 120 GTTEKTITNY RAINSRSNEA ALVEEIATAD VVTCSVGPNI LKFLAPVIAK GLAARSTDLT 130 140 150 160 170 180 PAAVIACENA IGATDTLAEF IKSPENTNPA LLEDYDKRAT FANSAIDRIV PAQDPDAGLD 190 200 210 220 230 240 VKLEKFYEWV VEKTPFKEWA VPDIKGIKWV DNLQPFIERK LYTVNTGHAT AAYYGYTRRK 250 260 270 280 290 300 STVYDALQDK DIRDEVKNAL KETADLITEK HGIDEEEQKQ YVDKIVRRIS NPHLEDAVER 310 320 330 340 350 360 VGRAPLRKLS RKERFIGPAA ELAENGKDCS ALLDAAEMAF RFQNVEGDDE SFELAKIMEE 370 380 390 KKPEEVVQEV CGLQPSEKLY PQVVDIVKRV QADSNEE

References

[1]

"The genome sequence of the model ascomycete fungus Podospora anserina." Espagne E., Lespinet O., Malagnac F., Da Silva C., Jaillon O., Porcel B.M., Couloux A., Aury J.-M., Segurens B., Poulain J., Anthouard V., Grossetete S., Khalili H., Coppin E., Dequard-Chablat M., Picard M., Contamine V., Arnaise S. , Bourdais A., Berteaux-Lecellier V., Gautheret D., de Vries R.P., Battaglia E., Coutinho P.M., Danchin E.G.J., Henrissat B., El Khoury R., Sainsard-Chanet A., Boivin A., Pinan-Lucarre B., Sellem C.H., Debuchy R., Wincker P., Weissenbach J., Silar P. Genome Biol. 9:RESEARCH77.1-RESEARCH77.22(2008) [PubMed: 18460219] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: S.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CU633872 Genomic DNA. Translation: CAP65533.1.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR013328. DH_multihelical. IPR013118. Mannitol_DH_C. IPR000669. Mannitol_DH_core. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
PROSITE	PS00974. MANNITOL_DHGENASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_PODAN

Accession

Primary (citable) accession number: B2AND4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 5, 2009
Last sequence update:	May 20, 2008
Last modified:	June 16, 2009
This is version 7 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)