B2AKF9 (B2AKF9_CUPTR) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
6,7-dimethyl-8-ribityllumazine synthase 2 HAMAP MF_00178
Short name=DMRL synthase 2 HAMAP MF_00178
Short name=Lumazine synthase 2 HAMAP MF_00178
EC=2.5.1.9 HAMAP MF_00178

Alternative name(s):
Riboflavin synthase beta chain 2 HAMAP MF_00178

Gene names

Name:	ribE2 EMBL CAP63986.1
Synonyms:	ribH2 HAMAP MF_00178
Ordered Locus Names:	pRALTA_0326

Encoded on

Plasmid pRALTA EMBL CAP63986.1

Organism

Cupriavidus taiwanensis (strain R1 / LMG 19424) (Ralstonia taiwanensis (strain LMG 19424)) [Complete proteome] [HAMAP]

Taxonomic identifier

164546 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Cupriavidus

Protein attributes

Sequence length	179 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2-butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The beta subunit catalyzes the condensation of 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate yielding 6,7-dimethyl-8-lumazine By similarity. HAMAP MF_00178
Catalytic activity	2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine. HAMAP MF_00178
Pathway	Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2. HAMAP MF_00178
Sequence similarities	Belongs to the DMRL synthase family. HAMAP MF_00178

Ontologies

Keywords
Biological process	Riboflavin biosynthesis HAMAP MF_00178
Molecular function	Transferase HAMAP MF_00178 EMBL CAP63986.1
Technical term	Complete proteome Plasmid EMBL CAP63986.1
Gene Ontology (GO)
Biological process	riboflavin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	riboflavin synthase complex Inferred from electronic annotation. Source: InterPro
Molecular function	riboflavin synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B2AKF9 [UniParc]. Last modified May 20, 2008. Version 1. Checksum: B0165A2F9998FE8B	FASTA	179	19,697
	10 20 30 40 50 60 MKTSIFSRAA RVAFIQAEWH KDLLENALEG FLRRMVQLGV STDAVDFFEV PGAFEIPLFA 70 80 90 100 110 120 KRIATRGDYA AIIESALVVD GGIYRHEFVA QAVVEGLMRV QLETDTPVFS MVLTPHNFRA 130 140 150 160 170 EEHMRGFFAK LLIEKGDEVA DACVRAVGCL ERPGGCMSAE AARHLAPGRV GERLISTTA

References

[1]

"Genome sequence of the beta-rhizobium Cupriavidus taiwanensis and comparative genomics of rhizobia." Amadou C., Pascal G., Mangenot S., Glew M., Bontemps C., Capela D., Carrere S., Cruveiller S., Dossat C., Lajus A., Marchetti M., Poinsot V., Rouy Z., Servin B., Saad M., Schenowitz C., Barbe V., Batut J., Medigue C., Masson-Boivin C. Genome Res. 18:1472-1483(2008) [PubMed: 18490699] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU633751 Genomic DNA. Translation: CAP63986.1.
RefSeq	YP_001796180.1. NC_010529.1.
3D structure databases
ProteinModelPortal	B2AKF9.
ModBase	Search...
Protein-protein interaction databases
STRING	B2AKF9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6302074.
GenomeReviews	Gene locus pRALTA_0326 in contig CU633751_GR.
KEGG	cti:pRALTA_0326.
PATRIC	21533455. VBICupTai42494_3348.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG311126.
OMA	RRYTAIV.
Family and domain databases
HAMAP	MF_00178. Lumazine_synth. [Tree]
InterPro	IPR002180. DMRL_synthase. [Graphical view]
Gene3D	G3DSA:3.40.50.960. DMRL_synthase. 1 hit.
KO	K00794.
PANTHER	PTHR21058. DMRL_synthase. 1 hit.
Pfam	PF00885. DMRL_synthase. 1 hit. [Graphical view]
SUPFAM	SSF52121. DMRL_synthase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B2AKF9_CUPTR

Accession

Primary (citable) accession number: B2AKF9

Entry history

Integrated into UniProtKB/TrEMBL:	May 20, 2008
Last sequence update:	May 20, 2008
Last modified:	December 14, 2011
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)