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B2AIJ6

- ACDH_CUPTR

UniProt

B2AIJ6 - ACDH_CUPTR

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Protein

Acetaldehyde dehydrogenase

Gene
mhpF, RALTA_B0400
Organism
Cupriavidus taiwanensis (strain R1 / LMG 19424) (Ralstonia taiwanensis (strain LMG 19424))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei130 – 1301Acyl-thioester intermediate By similarity
Binding sitei272 – 2721NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi161 – 1699NAD By similarity

GO - Molecular functioni

  1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
  2. NAD binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciCTAI164546:GJNE-3616-MONOMER.
CTAI977880:GLC7-3616-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase (EC:1.2.1.10)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]
Gene namesi
Name:mhpF
Ordered Locus Names:RALTA_B0400
OrganismiCupriavidus taiwanensis (strain R1 / LMG 19424) (Ralstonia taiwanensis (strain LMG 19424))
Taxonomic identifieri164546 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000001692: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301Acetaldehyde dehydrogenaseUniRule annotationPRO_0000387653Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi164546.RALTA_B0400.

Structurei

3D structure databases

ProteinModelPortaliB2AIJ6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK04073.
OMAiREVQKYV.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

B2AIJ6-1 [UniParc]FASTAAdd to Basket

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MNKIRCALIG PGNIGTDLLY KLRRSDILEP VWMVGVEPTS EGLARARELG    50
LKTTSDGIDG LLPHLEADDI RIAFDATSAY VHAEHSAKLT ARGVRVIDLT 100
PAAIGPFCVP PVNLAAHIGS NEMNVNMVTC GGQATIPMVY AVSRVQPVAY 150
GEIVATVSSR SVGPGTRRNI DEFTRTTAGA IEAVGGARQG KAIIVINPAE 200
PPLIMRDTIH CLTEDAPDVA AITASVHDMI AEVRKYVPGY TLKNGPVFDG 250
KRVSIFLEVE GLGDYLPKYA GNLDIMTASA ARTAECIAAA MRAGSPETAT 300
A 301
Length:301
Mass (Da):31,790
Last modified:May 20, 2008 - v1
Checksum:iD1F71ACCECE65A70
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU633750 Genomic DNA. Translation: CAP63595.1.
RefSeqiYP_001796832.1. NC_010530.1.

Genome annotation databases

EnsemblBacteriaiCAP63595; CAP63595; RALTA_B0400.
GeneIDi6302875.
KEGGicti:RALTA_B0400.
PATRICi21534597. VBICupTai42494_3913.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU633750 Genomic DNA. Translation: CAP63595.1 .
RefSeqi YP_001796832.1. NC_010530.1.

3D structure databases

ProteinModelPortali B2AIJ6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 164546.RALTA_B0400.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAP63595 ; CAP63595 ; RALTA_B0400 .
GeneIDi 6302875.
KEGGi cti:RALTA_B0400.
PATRICi 21534597. VBICupTai42494_3913.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K04073.
OMAi REVQKYV.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci CTAI164546:GJNE-3616-MONOMER.
CTAI977880:GLC7-3616-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: R1 / LMG 19424.

Entry informationi

Entry nameiACDH_CUPTR
AccessioniPrimary (citable) accession number: B2AIJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 20, 2008
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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