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Protein

Acetaldehyde dehydrogenase

Gene

mhpF

Organism
Cupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CIP 107171 / LMG 19424 / R1) (Ralstonia taiwanensis (strain LMG 19424))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei130Acyl-thioester intermediateUniRule annotation1
Binding sitei272NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi161 – 169NADUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAromatic hydrocarbons catabolism
LigandNAD

Enzyme and pathway databases

BioCyciCTAI977880:G1GJV-3554-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenaseUniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]UniRule annotation
Gene namesi
Name:mhpFUniRule annotation
Ordered Locus Names:RALTA_B0400
OrganismiCupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CIP 107171 / LMG 19424 / R1) (Ralstonia taiwanensis (strain LMG 19424))
Taxonomic identifieri977880 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
Proteomesi
  • UP000001692 Componenti: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003876531 – 301Acetaldehyde dehydrogenaseAdd BLAST301

Interactioni

Protein-protein interaction databases

STRINGi977880.RALTA_B0400

Structurei

3D structure databases

ProteinModelPortaliB2AIJ6
SMRiB2AIJ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DIV Bacteria
COG4569 LUCA
HOGENOMiHOG000052149
KOiK18366
OMAiTSAYVHK

Family and domain databases

HAMAPiMF_01657 Ac_ald_DH_ac, 1 hit
InterProiView protein in InterPro
IPR003361 Acetaldehyde_dehydrogenase
IPR015426 Acetylaldehyde_DH_C
IPR036291 NAD(P)-bd_dom_sf
IPR000534 Semialdehyde_DH_NAD-bd
PfamiView protein in Pfam
PF09290 AcetDehyd-dimer, 1 hit
PF01118 Semialdhyde_dh, 1 hit
PIRSFiPIRSF015689 Actaldh_dh_actl, 1 hit
SMARTiView protein in SMART
SM00859 Semialdhyde_dh, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR03215 ac_ald_DH_ac, 1 hit

Sequencei

Sequence statusi: Complete.

B2AIJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKIRCALIG PGNIGTDLLY KLRRSDILEP VWMVGVEPTS EGLARARELG
60 70 80 90 100
LKTTSDGIDG LLPHLEADDI RIAFDATSAY VHAEHSAKLT ARGVRVIDLT
110 120 130 140 150
PAAIGPFCVP PVNLAAHIGS NEMNVNMVTC GGQATIPMVY AVSRVQPVAY
160 170 180 190 200
GEIVATVSSR SVGPGTRRNI DEFTRTTAGA IEAVGGARQG KAIIVINPAE
210 220 230 240 250
PPLIMRDTIH CLTEDAPDVA AITASVHDMI AEVRKYVPGY TLKNGPVFDG
260 270 280 290 300
KRVSIFLEVE GLGDYLPKYA GNLDIMTASA ARTAECIAAA MRAGSPETAT

A
Length:301
Mass (Da):31,790
Last modified:May 20, 2008 - v1
Checksum:iD1F71ACCECE65A70
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU633750 Genomic DNA Translation: CAP63595.1
RefSeqiWP_012355249.1, NC_010530.1

Genome annotation databases

EnsemblBacteriaiCAP63595; CAP63595; RALTA_B0400
GeneIDi29764455
KEGGicti:RALTA_B0400

Similar proteinsi

Entry informationi

Entry nameiACDH_CUPTR
AccessioniPrimary (citable) accession number: B2AIJ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 20, 2008
Last modified: April 25, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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