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B2AIF3 (RBKTP_CUPTR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional ribose 1,5-bisphosphokinase-thymidine phosphorylase

Including the following 2 domains:

  1. Ribose 1,5-bisphosphate phosphokinase PhnN
    EC=2.7.4.23
    Alternative name(s):
    Ribose 1,5-bisphosphokinase
  2. Putative thymidine phosphorylase
    EC=2.4.2.4
    Alternative name(s):
    TdRPase
Gene names
Name:phnN
Ordered Locus Names:RALTA_B0356
OrganismCupriavidus taiwanensis (strain R1 / LMG 19424) (Ralstonia taiwanensis (strain LMG 19424)) [Complete proteome] [HAMAP]
Taxonomic identifier164546 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus

Protein attributes

Sequence length601 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) By similarity. HAMAP-Rule MF_00703

Catalytic activity

ATP + alpha-D-ribose 1,5-bisphosphate = ADP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_00703

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_00703

Pathway

Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II): step 3/3. HAMAP-Rule MF_00703

Sequence similarities

In the N-terminal section; belongs to the ribose 1,5-bisphosphokinase family.

In the C-terminal section; belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 601601Bifunctional ribose 1,5-bisphosphokinase-thymidine phosphorylase HAMAP-Rule MF_00703
PRO_0000412779

Regions

Nucleotide binding12 – 198ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
B2AIF3 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: 2C4BD4BA05B4E774

FASTA60163,485
        10         20         30         40         50         60 
MNASGTFFFV VGPSGAGKDA LMDGARAALD DNYVFARRVI TRPEGAVGEA HEAVSEAEFA 

        70         80         90        100        110        120 
RRQRSGEFLV TWDAHDLRYG LPCSLMSELE RGRHVVANGS RAVIAELAQR LPRFVVVLVT 

       130        140        150        160        170        180 
APQDVLARRI AARGRESGEQ IARRVARTGA ALPPEVRCLT VLNDSTLEVG RARFVEALRH 

       190        200        210        220        230        240 
GTRVASDGAP ASRTNLMAKL RGEPLDQAAY VAVLQDAMAG RYTEAELTEF LVAATRSLDD 

       250        260        270        280        290        300 
QEVVALARAR TVFTPRIKWD EPIVVDKHSI GGVPGSRITL IVVPIVAAYG LAMPKTSSRA 

       310        320        330        340        350        360 
ITSAAGTADA METVARVDLA HDDVRRCVAQ ARACIAWNGR LNHSVVDDVM NAITRPLRLD 

       370        380        390        400        410        420 
SRRWAVASIL SKKYTAGATH VIVDLPYGPQ TKLATRADAE ALGAMFEHVG KGLGLHVRAL 

       430        440        450        460        470        480 
VTDGSRPIGR GIGPALEVRD VRQVLANDPC APADLREKAL RFAGEIIAFD ARVGSPAEGL 

       490        500        510        520        530        540 
RIATALLSEG KAKAAFDRIA ATQGARPEPV APGAHTCVVS ATMQGRVAAI DGLRISGVAR 

       550        560        570        580        590        600 
AAGAPRELGA GVDLLCTIGA KVESGQPLYR IHAGSDAALA AAAALARAGG ECSEAVRIDP 


D 

« Hide

References

[1]"Genome sequence of the beta-rhizobium Cupriavidus taiwanensis and comparative genomics of rhizobia."
Amadou C., Pascal G., Mangenot S., Glew M., Bontemps C., Capela D., Carrere S., Cruveiller S., Dossat C., Lajus A., Marchetti M., Poinsot V., Rouy Z., Servin B., Saad M., Schenowitz C., Barbe V., Batut J., Medigue C., Masson-Boivin C.
Genome Res. 18:1472-1483(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: R1 / LMG 19424.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU633750 Genomic DNA. Translation: CAP63552.1.
RefSeqYP_001796789.1. NC_010530.1.

3D structure databases

ProteinModelPortalB2AIF3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING164546.RALTA_B0356.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAP63552; CAP63552; RALTA_B0356.
GeneID6302658.
KEGGcti:RALTA_B0356.
PATRIC21534507. VBICupTai42494_3868.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0213.
HOGENOMHOG000252767.
KOK00758.
OMACLIWGGH.
OrthoDBEOG61ZTGG.

Enzyme and pathway databases

BioCycCTAI164546:GJNE-3573-MONOMER.
CTAI977880:GLC7-3573-MONOMER.
UniPathwayUPA00087; UER00175.

Family and domain databases

Gene3D3.40.1030.10. 1 hit.
3.40.50.300. 2 hits.
3.90.1170.30. 1 hit.
HAMAPMF_00703. Thymid_phosp_2.
MF_00836. PhnN.
InterProIPR008145. GK/Ca_channel_bsu.
IPR000312. Glycosyl_Trfase_fam3.
IPR027417. P-loop_NTPase.
IPR012699. PhnN.
IPR013102. PYNP_C.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR028579. Thym_Pase_Put.
[Graphical view]
PANTHERPTHR10515. PTHR10515. 1 hit.
PfamPF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
SMARTSM00072. GuKc. 1 hit.
SM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMSSF52418. SSF52418. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsTIGR02322. phosphon_PhnN. 1 hit.
PROSITEPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRBKTP_CUPTR
AccessionPrimary (citable) accession number: B2AIF3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: May 20, 2008
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways