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B2AIF3

- RBKTP_CUPTR

UniProt

B2AIF3 - RBKTP_CUPTR

Protein

Bifunctional ribose 1,5-bisphosphokinase-thymidine phosphorylase

Gene

phnN

Organism
Cupriavidus taiwanensis (strain R1 / LMG 19424) (Ralstonia taiwanensis (strain LMG 19424))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (20 May 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP).By similarity

    Catalytic activityi

    ATP + alpha-D-ribose 1,5-bisphosphate = ADP + 5-phospho-alpha-D-ribose 1-diphosphate.
    Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 198ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphorylase activity Source: InterPro
    3. ribose 1,5-bisphosphate phosphokinase activity Source: UniProtKB-EC
    4. thymidine phosphorylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. 5-phosphoribose 1-diphosphate biosynthetic process Source: UniProtKB-UniPathway
    2. pyrimidine nucleobase metabolic process Source: InterPro
    3. pyrimidine nucleoside metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCTAI164546:GJNE-3573-MONOMER.
    CTAI977880:GLC7-3573-MONOMER.
    UniPathwayiUPA00087; UER00175.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional ribose 1,5-bisphosphokinase-thymidine phosphorylase
    Including the following 2 domains:
    Ribose 1,5-bisphosphate phosphokinase PhnN (EC:2.7.4.23)
    Alternative name(s):
    Ribose 1,5-bisphosphokinase
    Putative thymidine phosphorylase (EC:2.4.2.4)
    Alternative name(s):
    TdRPase
    Gene namesi
    Name:phnN
    Ordered Locus Names:RALTA_B0356
    OrganismiCupriavidus taiwanensis (strain R1 / LMG 19424) (Ralstonia taiwanensis (strain LMG 19424))
    Taxonomic identifieri164546 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
    ProteomesiUP000001692: Chromosome 2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 601601Bifunctional ribose 1,5-bisphosphokinase-thymidine phosphorylasePRO_0000412779Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi164546.RALTA_B0356.

    Structurei

    3D structure databases

    ProteinModelPortaliB2AIF3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    In the N-terminal section; belongs to the ribose 1,5-bisphosphokinase family.Curated
    In the C-terminal section; belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG0213.
    HOGENOMiHOG000252767.
    KOiK00758.
    OMAiCLIWGGH.
    OrthoDBiEOG61ZTGG.

    Family and domain databases

    Gene3Di3.40.1030.10. 1 hit.
    3.40.50.300. 2 hits.
    3.90.1170.30. 1 hit.
    HAMAPiMF_00703. Thymid_phosp_2.
    MF_00836. PhnN.
    InterProiIPR008145. GK/Ca_channel_bsu.
    IPR000312. Glycosyl_Trfase_fam3.
    IPR027417. P-loop_NTPase.
    IPR012699. PhnN.
    IPR013102. PYNP_C.
    IPR000053. Pyrmidine_PPase.
    IPR017872. Pyrmidine_PPase_CS.
    IPR028579. Thym_Pase_Put.
    [Graphical view]
    PANTHERiPTHR10515. PTHR10515. 1 hit.
    PfamiPF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view]
    SMARTiSM00072. GuKc. 1 hit.
    SM00941. PYNP_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF52418. SSF52418. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsiTIGR02322. phosphon_PhnN. 1 hit.
    PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2AIF3-1 [UniParc]FASTAAdd to Basket

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    MNASGTFFFV VGPSGAGKDA LMDGARAALD DNYVFARRVI TRPEGAVGEA    50
    HEAVSEAEFA RRQRSGEFLV TWDAHDLRYG LPCSLMSELE RGRHVVANGS 100
    RAVIAELAQR LPRFVVVLVT APQDVLARRI AARGRESGEQ IARRVARTGA 150
    ALPPEVRCLT VLNDSTLEVG RARFVEALRH GTRVASDGAP ASRTNLMAKL 200
    RGEPLDQAAY VAVLQDAMAG RYTEAELTEF LVAATRSLDD QEVVALARAR 250
    TVFTPRIKWD EPIVVDKHSI GGVPGSRITL IVVPIVAAYG LAMPKTSSRA 300
    ITSAAGTADA METVARVDLA HDDVRRCVAQ ARACIAWNGR LNHSVVDDVM 350
    NAITRPLRLD SRRWAVASIL SKKYTAGATH VIVDLPYGPQ TKLATRADAE 400
    ALGAMFEHVG KGLGLHVRAL VTDGSRPIGR GIGPALEVRD VRQVLANDPC 450
    APADLREKAL RFAGEIIAFD ARVGSPAEGL RIATALLSEG KAKAAFDRIA 500
    ATQGARPEPV APGAHTCVVS ATMQGRVAAI DGLRISGVAR AAGAPRELGA 550
    GVDLLCTIGA KVESGQPLYR IHAGSDAALA AAAALARAGG ECSEAVRIDP 600
    D 601
    Length:601
    Mass (Da):63,485
    Last modified:May 20, 2008 - v1
    Checksum:i2C4BD4BA05B4E774
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU633750 Genomic DNA. Translation: CAP63552.1.
    RefSeqiYP_001796789.1. NC_010530.1.

    Genome annotation databases

    EnsemblBacteriaiCAP63552; CAP63552; RALTA_B0356.
    GeneIDi6302658.
    KEGGicti:RALTA_B0356.
    PATRICi21534507. VBICupTai42494_3868.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU633750 Genomic DNA. Translation: CAP63552.1 .
    RefSeqi YP_001796789.1. NC_010530.1.

    3D structure databases

    ProteinModelPortali B2AIF3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 164546.RALTA_B0356.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAP63552 ; CAP63552 ; RALTA_B0356 .
    GeneIDi 6302658.
    KEGGi cti:RALTA_B0356.
    PATRICi 21534507. VBICupTai42494_3868.

    Phylogenomic databases

    eggNOGi COG0213.
    HOGENOMi HOG000252767.
    KOi K00758.
    OMAi CLIWGGH.
    OrthoDBi EOG61ZTGG.

    Enzyme and pathway databases

    UniPathwayi UPA00087 ; UER00175 .
    BioCyci CTAI164546:GJNE-3573-MONOMER.
    CTAI977880:GLC7-3573-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1030.10. 1 hit.
    3.40.50.300. 2 hits.
    3.90.1170.30. 1 hit.
    HAMAPi MF_00703. Thymid_phosp_2.
    MF_00836. PhnN.
    InterProi IPR008145. GK/Ca_channel_bsu.
    IPR000312. Glycosyl_Trfase_fam3.
    IPR027417. P-loop_NTPase.
    IPR012699. PhnN.
    IPR013102. PYNP_C.
    IPR000053. Pyrmidine_PPase.
    IPR017872. Pyrmidine_PPase_CS.
    IPR028579. Thym_Pase_Put.
    [Graphical view ]
    PANTHERi PTHR10515. PTHR10515. 1 hit.
    Pfami PF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view ]
    SMARTi SM00072. GuKc. 1 hit.
    SM00941. PYNP_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52418. SSF52418. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsi TIGR02322. phosphon_PhnN. 1 hit.
    PROSITEi PS00647. THYMID_PHOSPHORYLASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: R1 / LMG 19424.

    Entry informationi

    Entry nameiRBKTP_CUPTR
    AccessioniPrimary (citable) accession number: B2AIF3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 21, 2011
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3