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Protein

Bifunctional ribose 1,5-bisphosphokinase-thymidine phosphorylase

Gene

phnN

Organism
Cupriavidus taiwanensis (strain R1 / LMG 19424) (Ralstonia taiwanensis (strain LMG 19424))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP).By similarity

Catalytic activityi

ATP + alpha-D-ribose 1,5-bisphosphate = ADP + 5-phospho-alpha-D-ribose 1-diphosphate.
Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 198ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCTAI164546:GJNE-3573-MONOMER.
CTAI977880:GLC7-3573-MONOMER.
UniPathwayiUPA00087; UER00175.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional ribose 1,5-bisphosphokinase-thymidine phosphorylase
Including the following 2 domains:
Ribose 1,5-bisphosphate phosphokinase PhnN (EC:2.7.4.23)
Alternative name(s):
Ribose 1,5-bisphosphokinase
Putative thymidine phosphorylase (EC:2.4.2.4)
Alternative name(s):
TdRPase
Gene namesi
Name:phnN
Ordered Locus Names:RALTA_B0356
OrganismiCupriavidus taiwanensis (strain R1 / LMG 19424) (Ralstonia taiwanensis (strain LMG 19424))
Taxonomic identifieri164546 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000001692 Componenti: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 601601Bifunctional ribose 1,5-bisphosphokinase-thymidine phosphorylasePRO_0000412779Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi164546.RALTA_B0356.

Structurei

3D structure databases

ProteinModelPortaliB2AIF3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

In the N-terminal section; belongs to the ribose 1,5-bisphosphokinase family.Curated
In the C-terminal section; belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.Curated

Phylogenomic databases

eggNOGiCOG0213.
HOGENOMiHOG000252767.
KOiK00758.
OMAiMNAITRP.
OrthoDBiEOG61ZTGG.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
3.40.50.300. 2 hits.
3.90.1170.30. 1 hit.
HAMAPiMF_00703. Thymid_phosp_2.
MF_00836. PhnN.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR000312. Glycosyl_Trfase_fam3.
IPR027417. P-loop_NTPase.
IPR012699. PhnN.
IPR013102. PYNP_C.
IPR017872. Pyrmidine_PPase_CS.
IPR028579. Thym_Pase_Put.
IPR000053. Thymidine/pyrmidine_PPase.
[Graphical view]
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiPF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
SM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMiSSF52418. SSF52418. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsiTIGR02322. phosphon_PhnN. 1 hit.
PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2AIF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNASGTFFFV VGPSGAGKDA LMDGARAALD DNYVFARRVI TRPEGAVGEA
60 70 80 90 100
HEAVSEAEFA RRQRSGEFLV TWDAHDLRYG LPCSLMSELE RGRHVVANGS
110 120 130 140 150
RAVIAELAQR LPRFVVVLVT APQDVLARRI AARGRESGEQ IARRVARTGA
160 170 180 190 200
ALPPEVRCLT VLNDSTLEVG RARFVEALRH GTRVASDGAP ASRTNLMAKL
210 220 230 240 250
RGEPLDQAAY VAVLQDAMAG RYTEAELTEF LVAATRSLDD QEVVALARAR
260 270 280 290 300
TVFTPRIKWD EPIVVDKHSI GGVPGSRITL IVVPIVAAYG LAMPKTSSRA
310 320 330 340 350
ITSAAGTADA METVARVDLA HDDVRRCVAQ ARACIAWNGR LNHSVVDDVM
360 370 380 390 400
NAITRPLRLD SRRWAVASIL SKKYTAGATH VIVDLPYGPQ TKLATRADAE
410 420 430 440 450
ALGAMFEHVG KGLGLHVRAL VTDGSRPIGR GIGPALEVRD VRQVLANDPC
460 470 480 490 500
APADLREKAL RFAGEIIAFD ARVGSPAEGL RIATALLSEG KAKAAFDRIA
510 520 530 540 550
ATQGARPEPV APGAHTCVVS ATMQGRVAAI DGLRISGVAR AAGAPRELGA
560 570 580 590 600
GVDLLCTIGA KVESGQPLYR IHAGSDAALA AAAALARAGG ECSEAVRIDP

D
Length:601
Mass (Da):63,485
Last modified:May 20, 2008 - v1
Checksum:i2C4BD4BA05B4E774
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU633750 Genomic DNA. Translation: CAP63552.1.

Genome annotation databases

EnsemblBacteriaiCAP63552; CAP63552; RALTA_B0356.
KEGGicti:RALTA_B0356.
PATRICi21534507. VBICupTai42494_3868.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU633750 Genomic DNA. Translation: CAP63552.1.

3D structure databases

ProteinModelPortaliB2AIF3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi164546.RALTA_B0356.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAP63552; CAP63552; RALTA_B0356.
KEGGicti:RALTA_B0356.
PATRICi21534507. VBICupTai42494_3868.

Phylogenomic databases

eggNOGiCOG0213.
HOGENOMiHOG000252767.
KOiK00758.
OMAiMNAITRP.
OrthoDBiEOG61ZTGG.

Enzyme and pathway databases

UniPathwayiUPA00087; UER00175.
BioCyciCTAI164546:GJNE-3573-MONOMER.
CTAI977880:GLC7-3573-MONOMER.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
3.40.50.300. 2 hits.
3.90.1170.30. 1 hit.
HAMAPiMF_00703. Thymid_phosp_2.
MF_00836. PhnN.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR000312. Glycosyl_Trfase_fam3.
IPR027417. P-loop_NTPase.
IPR012699. PhnN.
IPR013102. PYNP_C.
IPR017872. Pyrmidine_PPase_CS.
IPR028579. Thym_Pase_Put.
IPR000053. Thymidine/pyrmidine_PPase.
[Graphical view]
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiPF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
SM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMiSSF52418. SSF52418. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsiTIGR02322. phosphon_PhnN. 1 hit.
PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: R1 / LMG 19424.

Entry informationi

Entry nameiRBKTP_CUPTR
AccessioniPrimary (citable) accession number: B2AIF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: May 20, 2008
Last modified: April 29, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.