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B2AH76

- PUR9_CUPTR

UniProt

B2AH76 - PUR9_CUPTR

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Protein

Bifunctional purine biosynthesis protein PurH

Gene
purH, RALTA_A0457
Organism
Cupriavidus taiwanensis (strain R1 / LMG 19424) (Ralstonia taiwanensis (strain LMG 19424))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciCTAI164546:GJNE-456-MONOMER.
CTAI977880:GLC7-456-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:RALTA_A0457
OrganismiCupriavidus taiwanensis (strain R1 / LMG 19424) (Ralstonia taiwanensis (strain LMG 19424))
Taxonomic identifieri164546 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000001692: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 524524Bifunctional purine biosynthesis protein PurHUniRule annotationPRO_1000096059Add
BLAST

Proteomic databases

PRIDEiB2AH76.

Interactioni

Protein-protein interaction databases

STRINGi164546.RALTA_A0457.

Structurei

3D structure databases

ProteinModelPortaliB2AH76.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiCGVATGP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

B2AH76-1 [UniParc]FASTAAdd to Basket

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MIKQALLSVS DKTGIVEFAR ELNALGVTLL STGGTAKLLA DSGLPVTEVA    50
DYTGFPEMLD GRVKTLHPKV HGGILARRDL PEHMAALAEH DIPTIDLLVV 100
NLYPFQQTVA KDDCTLPDAI ENIDIGGPTM LRSAAKNHRD VTVIVDPADY 150
AVVLGEMRAN GNSVGYDTNF RLATKVFAHT AQYDGAITNY LTSLGADKSH 200
QARSAYPQTL NLAFDKVQEM RYGENPHQSA AFYRDLKAVD GALANYVQLQ 250
GKELSYNNIA DADAAWECVK SFDAAAAAAC VIIKHANPCG VALGANALEA 300
YDKAFKTDST SAFGGIIAFN VELDEAAAQA VAKQFVEVLI APSFSAAARA 350
VFAAKQNVRL LEIPLGKGIN QYDFKRVGGG LLVQSPDAKN VQPSELRVVT 400
RRHPTPKEMD DLMFAWRVAK FVKSNAIVFC GGGMTLGVGA GQMSRVDSAR 450
IASIKAQNAG LTLAGSAVAS DAFFPFRDGL DVVVDAGATC VIQPGGSVRD 500
DEVIAAADEH GIAMVLTGTR HFRH 524
Length:524
Mass (Da):55,790
Last modified:May 20, 2008 - v1
Checksum:iCE27DE3E6335C493
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU633749 Genomic DNA. Translation: CAP63125.1.
RefSeqiYP_001795845.1. NC_010528.1.

Genome annotation databases

EnsemblBacteriaiCAP63125; CAP63125; RALTA_A0457.
GeneIDi6301701.
KEGGicti:RALTA_A0457.
PATRICi21527560. VBICupTai42494_0464.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU633749 Genomic DNA. Translation: CAP63125.1 .
RefSeqi YP_001795845.1. NC_010528.1.

3D structure databases

ProteinModelPortali B2AH76.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 164546.RALTA_A0457.

Proteomic databases

PRIDEi B2AH76.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAP63125 ; CAP63125 ; RALTA_A0457 .
GeneIDi 6301701.
KEGGi cti:RALTA_A0457.
PATRICi 21527560. VBICupTai42494_0464.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi CGVATGP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci CTAI164546:GJNE-456-MONOMER.
CTAI977880:GLC7-456-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: R1 / LMG 19424.

Entry informationi

Entry nameiPUR9_CUPTR
AccessioniPrimary (citable) accession number: B2AH76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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