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Protein

Holliday junction ATP-dependent DNA helicase RuvB

Gene

ruvB

Organism
Cupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CIP 107171 / LMG 19424 / R1) (Ralstonia taiwanensis (strain LMG 19424))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi69 – 76ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase
Biological processDNA damage, DNA recombination, DNA repair, SOS response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCTAI977880:G1GJV-446-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Holliday junction ATP-dependent DNA helicase RuvBUniRule annotation (EC:3.6.4.12UniRule annotation)
Gene namesi
Name:ruvBUniRule annotation
Ordered Locus Names:RALTA_A0453
OrganismiCupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CIP 107171 / LMG 19424 / R1) (Ralstonia taiwanensis (strain LMG 19424))
Taxonomic identifieri977880 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
Proteomesi
  • UP000001692 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000896371 – 354Holliday junction ATP-dependent DNA helicase RuvBAdd BLAST354

Interactioni

Subunit structurei

Forms a complex with RuvA.UniRule annotation

Protein-protein interaction databases

STRINGi977880.RALTA_A0453

Structurei

3D structure databases

ProteinModelPortaliB2AH72
SMRiB2AH72
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CKJ Bacteria
COG2255 LUCA
HOGENOMiHOG000218623
KOiK03551
OMAiDEIHRMS

Family and domain databases

Gene3Di1.10.10.10, 1 hit
HAMAPiMF_00016 DNA_helic_RuvB, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR004605 DNA_helicase_Holl-junc_RuvB
IPR008823 DNA_helicase_Holl-junc_RuvB_C
IPR027417 P-loop_NTPase
IPR008824 RuvB_N
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR42848 PTHR42848, 1 hit
PfamiView protein in Pfam
PF05491 RuvB_C, 1 hit
PF05496 RuvB_N, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005323 DNA_helicase_Holl-junc_RuvB_C, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00635 ruvB, 1 hit

Sequencei

Sequence statusi: Complete.

B2AH72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIETDKLAAP ARVIAATPAS SQEEAFERAL RPKLLDEYVG QEKVRGQLDI
60 70 80 90 100
FMHAARKRRE ALDHVLLFGP PGLGKTTLAH IIAREMGVSL RQTSGPVLER
110 120 130 140 150
PGDLAALLTN LEANDVLFID EIHRLSPVVE EILYPALEDY QIDIMIGEGP
160 170 180 190 200
AARSVKLDLQ PFTLVGATTR AGMLTNPLRD RFGIVARLEF YTAEELARIV
210 220 230 240 250
TRSAQLLQAR IDPQGALEIA RRARGTPRIA NRLLRRVRDY AEVKGDGTIT
260 270 280 290 300
REMADAALAM LDVDRVGFDL MDRKLLEAVL HKFGGGPVGV DNLAAAIGEE
310 320 330 340 350
RDTIEDVLEP YLIQQGYLQR TPRGRVATAA AYRHFGLASP QGMAGDAGEL

FGDA
Length:354
Mass (Da):38,791
Last modified:May 20, 2008 - v1
Checksum:i6BE2F9D2B31A25D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU633749 Genomic DNA Translation: CAP63121.1
RefSeqiWP_012351782.1, NC_010528.1

Genome annotation databases

EnsemblBacteriaiCAP63121; CAP63121; RALTA_A0453
GeneIDi29760702
KEGGicti:RALTA_A0453

Similar proteinsi

Entry informationi

Entry nameiRUVB_CUPTR
AccessioniPrimary (citable) accession number: B2AH72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: April 25, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health