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Protein

ATP-dependent protease subunit HslV

Gene

hslV

Organism
Cupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CIP 107171 / LMG 19424 / R1) (Ralstonia taiwanensis (strain LMG 19424))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.UniRule annotation

Catalytic activityi

ATP-dependent cleavage of peptide bonds with broad specificity.UniRule annotation

Enzyme regulationi

Allosterically activated by HslU binding.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei7UniRule annotation1
Metal bindingi162Sodium; via carbonyl oxygenUniRule annotation1
Metal bindingi165Sodium; via carbonyl oxygenUniRule annotation1
Metal bindingi168Sodium; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Keywords - Ligandi

Metal-binding, Sodium

Enzyme and pathway databases

BioCyciCTAI164546:GJNE-142-MONOMER.
CTAI977880:GLC7-142-MONOMER.

Protein family/group databases

MEROPSiT01.006.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent protease subunit HslVUniRule annotation (EC:3.4.25.2UniRule annotation)
Gene namesi
Name:hslVUniRule annotation
Ordered Locus Names:RALTA_A0142
OrganismiCupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CIP 107171 / LMG 19424 / R1) (Ralstonia taiwanensis (strain LMG 19424))
Taxonomic identifieri977880 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
Proteomesi
  • UP000001692 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001008871 – 178ATP-dependent protease subunit HslVAdd BLAST178

Interactioni

Subunit structurei

A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.UniRule annotation

Protein-protein interaction databases

STRINGi977880.RALTA_A0142.

Structurei

3D structure databases

ProteinModelPortaliB2AGB6.
SMRiB2AGB6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family. HslV subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108R5P. Bacteria.
COG5405. LUCA.
HOGENOMiHOG000064533.
KOiK01419.
OMAiIMKGNAR.

Family and domain databases

CDDicd01913. protease_HslV. 1 hit.
Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00248. HslV. 1 hit.
InterProiIPR022281. ATP-dep_Prtase_HsIV_su.
IPR029055. Ntn_hydrolases_N.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
[Graphical view]
PIRSFiPIRSF039093. HslV. 1 hit.
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR03692. ATP_dep_HslV. 1 hit.
PROSITEiPS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2AGB6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQYHGTTIV SVRRGNQVAL GGDGQVTLGN IVMKGTARKV RRIYNGKVLV
60 70 80 90 100
GFAGSTADAF SLLDRFEAKL EKYQGNLTRA AVDLAKDWRS DRALRRLEAM
110 120 130 140 150
LITADRDTTL VITGNGDVLD PEGGIAAIGS GGAYAQSAAK ALMENTEMAP
160 170
KDVVEKALTI AGELCIYTNT NFVIETLE
Length:178
Mass (Da):19,097
Last modified:May 20, 2008 - v1
Checksum:i4B2D01AE73DA88A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU633749 Genomic DNA. Translation: CAP62815.1.
RefSeqiWP_012351483.1. NC_010528.1.

Genome annotation databases

EnsemblBacteriaiCAP62815; CAP62815; RALTA_A0142.
KEGGicti:RALTA_A0142.
PATRICi21526914. VBICupTai42494_0143.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU633749 Genomic DNA. Translation: CAP62815.1.
RefSeqiWP_012351483.1. NC_010528.1.

3D structure databases

ProteinModelPortaliB2AGB6.
SMRiB2AGB6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi977880.RALTA_A0142.

Protein family/group databases

MEROPSiT01.006.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAP62815; CAP62815; RALTA_A0142.
KEGGicti:RALTA_A0142.
PATRICi21526914. VBICupTai42494_0143.

Phylogenomic databases

eggNOGiENOG4108R5P. Bacteria.
COG5405. LUCA.
HOGENOMiHOG000064533.
KOiK01419.
OMAiIMKGNAR.

Enzyme and pathway databases

BioCyciCTAI164546:GJNE-142-MONOMER.
CTAI977880:GLC7-142-MONOMER.

Family and domain databases

CDDicd01913. protease_HslV. 1 hit.
Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00248. HslV. 1 hit.
InterProiIPR022281. ATP-dep_Prtase_HsIV_su.
IPR029055. Ntn_hydrolases_N.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
[Graphical view]
PIRSFiPIRSF039093. HslV. 1 hit.
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR03692. ATP_dep_HslV. 1 hit.
PROSITEiPS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHSLV_CUPTR
AccessioniPrimary (citable) accession number: B2AGB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: November 2, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.