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Protein

ATP-dependent protease subunit HslV

Gene

hslV

Organism
Cupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CIP 107171 / LMG 19424 / R1) (Ralstonia taiwanensis (strain LMG 19424))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.UniRule annotation

Catalytic activityi

ATP-dependent cleavage of peptide bonds with broad specificity.UniRule annotation

Enzyme regulationi

Allosterically activated by HslU binding.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei7UniRule annotation1
Metal bindingi162Sodium; via carbonyl oxygenUniRule annotation1
Metal bindingi165Sodium; via carbonyl oxygenUniRule annotation1
Metal bindingi168Sodium; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAllosteric enzyme, Hydrolase, Protease, Threonine protease
LigandMetal-binding, Sodium

Protein family/group databases

MEROPSiT01.006

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent protease subunit HslVUniRule annotation (EC:3.4.25.2UniRule annotation)
Gene namesi
Name:hslVUniRule annotation
Ordered Locus Names:RALTA_A0142
OrganismiCupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CIP 107171 / LMG 19424 / R1) (Ralstonia taiwanensis (strain LMG 19424))
Taxonomic identifieri977880 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
Proteomesi
  • UP000001692 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001008871 – 178ATP-dependent protease subunit HslVAdd BLAST178

Interactioni

Subunit structurei

A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.UniRule annotation

Protein-protein interaction databases

STRINGi977880.RALTA_A0142

Structurei

3D structure databases

ProteinModelPortaliB2AGB6
SMRiB2AGB6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family. HslV subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108R5P Bacteria
COG5405 LUCA
HOGENOMiHOG000064533
KOiK01419
OMAiIMKGNAR

Family and domain databases

CDDicd01913 protease_HslV, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00248 HslV, 1 hit
InterProiView protein in InterPro
IPR022281 ATP-dep_Prtase_HsIV_su
IPR029055 Ntn_hydrolases_N
IPR001353 Proteasome_sua/b
IPR023333 Proteasome_suB-type
PANTHERiPTHR32194 PTHR32194, 1 hit
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PIRSFiPIRSF039093 HslV, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR03692 ATP_dep_HslV, 1 hit
PROSITEiView protein in PROSITE
PS51476 PROTEASOME_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

B2AGB6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQYHGTTIV SVRRGNQVAL GGDGQVTLGN IVMKGTARKV RRIYNGKVLV
60 70 80 90 100
GFAGSTADAF SLLDRFEAKL EKYQGNLTRA AVDLAKDWRS DRALRRLEAM
110 120 130 140 150
LITADRDTTL VITGNGDVLD PEGGIAAIGS GGAYAQSAAK ALMENTEMAP
160 170
KDVVEKALTI AGELCIYTNT NFVIETLE
Length:178
Mass (Da):19,097
Last modified:May 20, 2008 - v1
Checksum:i4B2D01AE73DA88A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU633749 Genomic DNA Translation: CAP62815.1
RefSeqiWP_012351483.1, NC_010528.1

Genome annotation databases

EnsemblBacteriaiCAP62815; CAP62815; RALTA_A0142
GeneIDi29762097
KEGGicti:RALTA_A0142

Similar proteinsi

Entry informationi

Entry nameiHSLV_CUPTR
AccessioniPrimary (citable) accession number: B2AGB6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: April 25, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
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