ID   B2AAV8_PODAN            Unreviewed;       783 AA.
AC   B2AAV8;
DT   20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT   20-MAY-2008, sequence version 1.
DT   27-MAR-2024, entry version 82.
DE   RecName: Full=histone deacetylase {ECO:0000256|ARBA:ARBA00012111};
DE            EC=3.5.1.98 {ECO:0000256|ARBA:ARBA00012111};
GN   ORFNames=PODANS_1_5330 {ECO:0000313|EMBL:CAP60220.1};
OS   Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383)
OS   (Pleurage anserina).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Podosporaceae; Podospora;
OC   Podospora anserina.
OX   NCBI_TaxID=515849 {ECO:0000313|EMBL:CAP60220.1};
RN   [1] {ECO:0000313|EMBL:CAP60220.1, ECO:0000313|Proteomes:UP000001197}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S / ATCC MYA-4624 / DSM 980 / FGSC 10383
RC   {ECO:0000313|Proteomes:UP000001197}, and S mat+
RC   {ECO:0000313|EMBL:CAP60220.1};
RX   PubMed=18460219; DOI=10.1186/gb-2008-9-5-r77;
RA   Espagne E., Lespinet O., Malagnac F., Da Silva C., Jaillon O., Porcel B.M.,
RA   Couloux A., Aury J.-M., Segurens B., Poulain J., Anthouard V.,
RA   Grossetete S., Khalili H., Coppin E., Dequard-Chablat M., Picard M.,
RA   Contamine V., Arnaise S., Bourdais A., Berteaux-Lecellier V., Gautheret D.,
RA   de Vries R.P., Battaglia E., Coutinho P.M., Danchin E.G.J., Henrissat B.,
RA   El Khoury R., Sainsard-Chanet A., Boivin A., Pinan-Lucarre B., Sellem C.H.,
RA   Debuchy R., Wincker P., Weissenbach J., Silar P.;
RT   "The genome sequence of the model ascomycete fungus Podospora anserina.";
RL   Genome Biol. 9:R77.1-R77.22(2008).
RN   [2] {ECO:0000313|EMBL:CAP60220.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=S mat+ {ECO:0000313|EMBL:CAP60220.1};
RA   Genoscope - CEA;
RL   Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Proteomes:UP000001197}
RP   GENOME REANNOTATION.
RC   STRAIN=S / ATCC MYA-4624 / DSM 980 / FGSC 10383
RC   {ECO:0000313|Proteomes:UP000001197};
RX   PubMed=24558260; DOI=10.1534/genetics.113.159988;
RA   Grognet P., Bidard F., Kuchly C., Tong L.C.H., Coppin E., Benkhali J.A.,
RA   Couloux A., Wincker P., Debuchy R., Silar P.;
RT   "Maintaining two mating types: Structure of the mating type locus and its
RT   role in heterokaryosis in Podospora anserina.";
RL   Genetics 197:421-432(2014).
RN   [4] {ECO:0000313|EMBL:CDP22861.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Grognet P., Bidard F., Kuchly C., Chan Ho Tong L., Coppin E.,
RA   Ait Benkhali J., Couloux A., Wincker P., Debuchy R., Silar P.;
RT   "Maintaining two mating types: Structure of the mating type locus and its
RT   role in heterokaryosis in Podospora anserina.";
RL   Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the histone deacetylase family. HD type 1
CC       subfamily. {ECO:0000256|ARBA:ARBA00006457}.
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DR   EMBL; CU633438; CAP60220.1; -; Genomic_DNA.
DR   EMBL; FO904936; CDP22861.1; -; Genomic_DNA.
DR   RefSeq; XP_001912738.1; XM_001912703.1.
DR   AlphaFoldDB; B2AAV8; -.
DR   STRING; 515849.B2AAV8; -.
DR   GeneID; 6196758; -.
DR   KEGG; pan:PODANSg09787; -.
DR   VEuPathDB; FungiDB:PODANS_1_5330; -.
DR   eggNOG; KOG1342; Eukaryota.
DR   HOGENOM; CLU_007727_0_1_1; -.
DR   OrthoDB; 1327607at2759; -.
DR   Proteomes; UP000001197; Chromosome 1.
DR   GO; GO:1902494; C:catalytic complex; IEA:UniProt.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR   GO; GO:0004407; F:histone deacetylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0010468; P:regulation of gene expression; IEA:UniProt.
DR   CDD; cd10004; RPD3-like; 1.
DR   Gene3D; 3.40.800.20; Histone deacetylase domain; 1.
DR   InterPro; IPR000286; His_deacetylse.
DR   InterPro; IPR003084; His_deacetylse_1.
DR   InterPro; IPR023801; His_deacetylse_dom.
DR   InterPro; IPR037138; His_deacetylse_dom_sf.
DR   InterPro; IPR023696; Ureohydrolase_dom_sf.
DR   PANTHER; PTHR10625:SF13; HISTONE DEACETYLASE HDAC1; 1.
DR   PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR   Pfam; PF00850; Hist_deacetyl; 1.
DR   PRINTS; PR01270; HDASUPER.
DR   PRINTS; PR01271; HISDACETLASE.
DR   SUPFAM; SSF52768; Arginase/deacetylase; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001197}.
FT   DOMAIN          196..484
FT                   /note="Histone deacetylase"
FT                   /evidence="ECO:0000259|Pfam:PF00850"
FT   REGION          545..603
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          616..635
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          666..783
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        574..594
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        617..633
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        697..721
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        722..750
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        767..783
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   783 AA;  87632 MW;  90085EF360F56F60 CRC64;
     MDPLTSALSN LREPRRRRGI GELPSSLVAA AHGLSAEHQL FPHTQNGGAD FDSPTFLLSH
     GSERTYIKYE DDTRINLLNW PSHPGRAKLD WDSSRDPDPG FEPIPFCPPL LSPIRFLPSS
     REHEHHELDE LCETKETPPQ HTFSSIRFAT MSNSNSTDPA GVERTRPLFE VVKNDKKRVA
     YFYDSDIGNY AYVTGHPMKP HRIRLAHSLV MNYNVYKFLE IYRAKPAVTS EMTQFHTDEY
     IEFLQKVTPD NMDSFMREQG KYNVGDDCPV FDGLFEFCGI SAGGSMEGAA RLNREKCDIA
     INWAGGLHHA KKSEASGFCY VNDIVLAILE LLRFKKRVLY IDIDVHHGDG VEEAFYTTDR
     VMTVSFHKYG EYFPGTGELR DIGIGTGKHY AVNFPLRDGI DDVAYETIFE PVITNVMQYY
     QPEAVVLQCG GDSLSGDRLG CFNLSMRGHA NCVNFVRGFN LPTLVLGGGG YTMRNVARTW
     AYETGRLVGV EMDRVLPFNE YYEYYGPDYE LDVRNSNMEN ANSYEYLEKI KIQVIENLKR
     TAPVPSVQMQ DVPRQSMGVS DDQDDEMDDL DEDENKDVRM TQRQWEKRVE RQDEYEDSDD
     EDMAAANGVF KLNGRTRQET NFRDTKEDDT MEVDSGVATP AEQPVEITEN DDTMIDEALA
     EIAAEAEAEA QVKEPAATET APEAPTAAVD GDGDVDMGEV TESKAAETVI KTEDVEEPVP
     AKQDDSQSTA VVSPKKTTEV AAQPSRTSKS PEPAVAADKQ TESVPEASEV VPPTTTQDNT
     TNS
//