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B2AAJ5

- 3HAO_PODAN

UniProt

B2AAJ5 - 3HAO_PODAN

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Protein

3-hydroxyanthranilate 3,4-dioxygenase

Gene

BNA1

Organism
Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.UniRule annotation

Catalytic activityi

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.UniRule annotation

Cofactori

Fe2+ ion.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei44 – 441DioxygenUniRule annotation
Metal bindingi48 – 481Iron; catalyticUniRule annotation
Metal bindingi54 – 541Iron; catalyticUniRule annotation
Binding sitei54 – 541SubstrateUniRule annotation
Metal bindingi95 – 951Iron; catalyticUniRule annotation
Binding sitei99 – 991SubstrateUniRule annotation
Binding sitei109 – 1091SubstrateUniRule annotation
Metal bindingi124 – 1241Divalent metal cationUniRule annotation
Metal bindingi127 – 1271Divalent metal cationUniRule annotation
Metal bindingi161 – 1611Divalent metal cationUniRule annotation
Metal bindingi164 – 1641Divalent metal cationUniRule annotation

GO - Molecular functioni

  1. 3-hydroxyanthranilate 3,4-dioxygenase activity Source: UniProtKB-HAMAP
  2. ferrous iron binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  4. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00253; UER00330.

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyanthranilate 3,4-dioxygenaseUniRule annotation (EC:1.13.11.6UniRule annotation)
Alternative name(s):
3-hydroxyanthranilate oxygenaseUniRule annotation
Short name:
3-HAOUniRule annotation
3-hydroxyanthranilic acid dioxygenaseUniRule annotation
Short name:
HADUniRule annotation
Biosynthesis of nicotinic acid protein 1UniRule annotation
Gene namesi
Name:BNA1UniRule annotation
Ordered Locus Names:PODANS_1_4230
OrganismiPodospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
Taxonomic identifieri515849 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesLasiosphaeriaceaePodospora
ProteomesiUP000001197: Chromosome 1

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1851853-hydroxyanthranilate 3,4-dioxygenasePRO_0000361994Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliB2AAJ5.
SMRiB2AAJ5. Positions 3-164.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 3-HAO family.UniRule annotation

Phylogenomic databases

KOiK00452.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
HAMAPiMF_00825. 3_HAO.
InterProiIPR010329. 3hydroanth_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR15497. PTHR15497. 1 hit.
PfamiPF06052. 3-HAO. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR03037. anthran_nbaC. 1 hit.

Sequencei

Sequence statusi: Complete.

B2AAJ5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLTQPINLPK WLEENSHLLK PPINNYCVYN EGFTVMIVGG PNARTDYHIN
60 70 80 90 100
QTPEWFYQHR GAMLLKIVDP TDNNTFKDII IRQGDMFLLP PNTPHNPVRF
110 120 130 140 150
ADTVGIVLEQ ERPEGSIDRM RWYCQSCKEI VHEASFHCTD LGTQIKAAVE
160 170 180
AFKEDEEKRT CKKCGEVAAW KPAEGSLKDP NLEEA
Length:185
Mass (Da):21,186
Last modified:May 20, 2008 - v1
Checksum:iD50D06BC49568576
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU633438 Genomic DNA. Translation: CAP60107.1.
RefSeqiXP_001912625.1. XM_001912590.1.

Genome annotation databases

GeneIDi6196987.
KEGGipan:PODANSg09674.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU633438 Genomic DNA. Translation: CAP60107.1 .
RefSeqi XP_001912625.1. XM_001912590.1.

3D structure databases

ProteinModelPortali B2AAJ5.
SMRi B2AAJ5. Positions 3-164.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 6196987.
KEGGi pan:PODANSg09674.

Phylogenomic databases

KOi K00452.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00330 .

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
HAMAPi MF_00825. 3_HAO.
InterProi IPR010329. 3hydroanth_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR15497. PTHR15497. 1 hit.
Pfami PF06052. 3-HAO. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR03037. anthran_nbaC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S / ATCC MYA-4624 / DSM 980 / FGSC 10383.

Entry informationi

Entry namei3HAO_PODAN
AccessioniPrimary (citable) accession number: B2AAJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: May 20, 2008
Last modified: October 29, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3