Skip Header

Contribute Send feedback
Read comments (?) or add your own

B2AAJ5 (3HAO_PODAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 6, 2013. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-hydroxyanthranilate 3,4-dioxygenase
EC=1.13.11.6
Alternative name(s):
3-hydroxyanthranilate oxygenase
Short name=3-HAO
3-hydroxyanthranilic acid dioxygenase
Short name=HAD
Biosynthesis of nicotinic acid protein 1
Gene names
Name:BNA1
ORF Names:Pa_1_4230
OrganismPodospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina) [Complete proteome]
Taxonomic identifier515849 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Lasiosphaeriaceae › Podospora ›

Protein attributes

Sequence length185 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate By similarity. HAMAP-Rule MF_03019

Catalytic activity

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde. HAMAP-Rule MF_03019

Cofactor

Fe2+ ion By similarity.

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3. HAMAP-Rule MF_03019

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the 3-HAO family.

Ontologies

Keywords
   Biological processPyridine nucleotide biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionDioxygenase
Oxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processNAD biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function3-hydroxyanthranilate 3,4-dioxygenase activity

Inferred from electronic annotation. Source: EC

iron ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 1851853-hydroxyanthranilate 3,4-dioxygenase HAMAP-Rule MF_03019
PRO_0000361994

Sites

Metal binding481Iron; catalytic By similarity
Metal binding541Iron; catalytic By similarity
Metal binding951Iron; catalytic By similarity
Metal binding1241Divalent metal cation By similarity
Metal binding1271Divalent metal cation By similarity
Metal binding1611Divalent metal cation By similarity
Metal binding1641Divalent metal cation By similarity
Binding site441Dioxygen By similarity
Binding site541Substrate By similarity
Binding site991Substrate By similarity
Binding site1091Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
B2AAJ5 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: D50D06BC49568576

FASTA18521,186
        10         20         30         40         50         60 
MLTQPINLPK WLEENSHLLK PPINNYCVYN EGFTVMIVGG PNARTDYHIN QTPEWFYQHR 

        70         80         90        100        110        120 
GAMLLKIVDP TDNNTFKDII IRQGDMFLLP PNTPHNPVRF ADTVGIVLEQ ERPEGSIDRM 

       130        140        150        160        170        180 
RWYCQSCKEI VHEASFHCTD LGTQIKAAVE AFKEDEEKRT CKKCGEVAAW KPAEGSLKDP 


NLEEA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU633438 Genomic DNA. Translation: CAP60107.1.
RefSeqXP_001912625.1. XM_001912590.1.

3D structure databases

ProteinModelPortalB2AAJ5.
SMRB2AAJ5. Positions 3-164.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6196987.
KEGGpan:PODANSg09674.

Phylogenomic databases

KOK00452.

Enzyme and pathway databases

UniPathwayUPA00253; UER00330.

Family and domain databases

Gene3D2.60.120.10. 1 hit.
HAMAPMF_00825. 3_HAO.
InterProIPR010329. 3hydroanth_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERPTHR15497. PTHR15497. 1 hit.
PfamPF06052. 3-HAO. 1 hit.
[Graphical view]
SUPFAMSSF51182. RmlC_like_cupin. 1 hit.
TIGRFAMsTIGR03037. anthran_nbaC. 1 hit.
ProtoNetSearch...

Entry information

Entry name3HAO_PODAN
AccessionPrimary (citable) accession number: B2AAJ5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: May 20, 2008
Last modified: March 6, 2013
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents