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B2A951

- DAPB_PODAN

UniProt

B2A951 - DAPB_PODAN

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Protein

Probable dipeptidyl-aminopeptidase B

Gene
DAPB, PODANS_1_8430
Organism
Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei769 – 7691Charge relay system By similarity
Active sitei846 – 8461Charge relay system By similarity
Active sitei879 – 8791Charge relay system By similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:DAPB
Ordered Locus Names:PODANS_1_8430
OrganismiPodospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
Taxonomic identifieri515849 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesLasiosphaeriaceaePodospora
ProteomesiUP000001197: Chromosome 1

Subcellular locationi

Vacuole membrane; Single-pass type II membrane protein By similarity
Note: Lysosome-like vacuoles By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 108108Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei109 – 12921Helical; Signal-anchor for type II membrane protein; Reviewed predictionAdd
BLAST
Topological domaini130 – 927798Vacuolar Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 927927Probable dipeptidyl-aminopeptidase BPRO_0000412159Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi365 – 3651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi530 – 5301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi828 – 8281N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliB2A951.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK01282.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

B2A951-1 [UniParc]FASTAAdd to Basket

« Hide

MAPAPGMAPY SDEPTGPFHR PEHNDESTGR MSHESESSVS TTSIVFDRIE    50
ERLAAKEGHF ELDDHDPMKE ADDDDNDLET GRFLGGRSST QEEDFPAKND 100
GMNRGMRRTL IIVAGLLISA WVVGLFFYVS HKSYKPASQI EHDPQATVVQ 150
GTGKQVTLDQ VMGSYWRAES HSISWIESPD GEDGLLLLKD GPGKDFLVVE 200
DVRTQNSAGV NAAVDVASSR TLIKERHFDF GGQTHTPGRV WPSKDLKKVL 250
IATNLEANWR HSFYASYWVF DVDMQIAEPL IPGEPNVRVQ LAQWSPTSDA 300
IAYVRDNNLF LRSLKHDKVV QITKDGGAEV FNGVPDWVYE EEVFSGNSAT 350
WWSEDGNYIA YLRTNETGVP EYPVQYFLSR PSGTEPAPGE ESYPEVRQIK 400
YPKAGAHNPV VNLKFYDVAR DESFTVEISG RFADDDRLIT EVVWAGGQVI 450
VKETNRVSDV LRVVLVDVAA RTGKAVRELD VKAIDGGWFE ITHKTKYIPA 500
DPSKGREQDG YIDMVIHDDN DHLAYFTPLN NSEPIMLTSG HWEVVDAPST 550
VDLDNNIVYF VATKESSIQR HVYQVDLSGN NLKAVTDTGS EGYYDISFSA 600
GTGYALLSYR GPNIPWQKVI STPANAHKYE HMVEENKELA KSAREYELPI 650
KIYGTIKVDG VELNYVERRP PHFDKNKKYP VLFQQYSGPG SQSVNKRFTV 700
DYQSYVAAGL GYVCVTVDGR GTGFIGRKNR VIIRGDLGKW EAHDQIAAAK 750
IWASKSYVDE ERLAIWGWSF GGFNTLKTLE QDGGRTFKYG MAVAPVTDWR 800
FYDSIYTERY MLTPQTNGHG YDTSAINNVT ALKQSVRFLM MHGVADDNVH 850
MQNSLTLLDK LNMVGVENYD VHVFPDSDHG IYFHNANRIV YDKLTNWLIN 900
AFNGEWIKVA NAKPQKKRSI QPILPIL 927
Length:927
Mass (Da):104,169
Last modified:May 20, 2008 - v1
Checksum:i288D2A5A7DD9AC52
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU633438 Genomic DNA. Translation: CAP60552.1.
RefSeqiXP_001913070.1. XM_001913035.1.

Genome annotation databases

GeneIDi6197654.
KEGGipan:PODANSg10119.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU633438 Genomic DNA. Translation: CAP60552.1 .
RefSeqi XP_001913070.1. XM_001913035.1.

3D structure databases

ProteinModelPortali B2A951.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 6197654.
KEGGi pan:PODANSg10119.

Phylogenomic databases

KOi K01282.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S / ATCC MYA-4624 / DSM 980 / FGSC 10383.

Entry informationi

Entry nameiDAPB_PODAN
AccessioniPrimary (citable) accession number: B2A951
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: May 20, 2008
Last modified: June 11, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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