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B2A951 (DAPB_PODAN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable dipeptidyl-aminopeptidase B

Short name=DPAP B
EC=3.4.14.5
Gene names
Name:DAPB
Ordered Locus Names:PODANS_1_8430
OrganismPodospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina) [Complete proteome]
Taxonomic identifier515849 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesLasiosphaeriaceaePodospora

Protein attributes

Sequence length927 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activity

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Subcellular location

Vacuole membrane; Single-pass type II membrane protein By similarity. Note: Lysosome-like vacuoles By similarity.

Sequence similarities

Belongs to the peptidase S9B family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 927927Probable dipeptidyl-aminopeptidase B
PRO_0000412159

Regions

Topological domain1 – 108108Cytoplasmic Potential
Transmembrane109 – 12921Helical; Signal-anchor for type II membrane protein; Potential
Topological domain130 – 927798Vacuolar Potential

Sites

Active site7691Charge relay system By similarity
Active site8461Charge relay system By similarity
Active site8791Charge relay system By similarity

Amino acid modifications

Glycosylation3651N-linked (GlcNAc...) Potential
Glycosylation5301N-linked (GlcNAc...) Potential
Glycosylation8281N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
B2A951 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: 288D2A5A7DD9AC52

FASTA927104,169
        10         20         30         40         50         60 
MAPAPGMAPY SDEPTGPFHR PEHNDESTGR MSHESESSVS TTSIVFDRIE ERLAAKEGHF 

        70         80         90        100        110        120 
ELDDHDPMKE ADDDDNDLET GRFLGGRSST QEEDFPAKND GMNRGMRRTL IIVAGLLISA 

       130        140        150        160        170        180 
WVVGLFFYVS HKSYKPASQI EHDPQATVVQ GTGKQVTLDQ VMGSYWRAES HSISWIESPD 

       190        200        210        220        230        240 
GEDGLLLLKD GPGKDFLVVE DVRTQNSAGV NAAVDVASSR TLIKERHFDF GGQTHTPGRV 

       250        260        270        280        290        300 
WPSKDLKKVL IATNLEANWR HSFYASYWVF DVDMQIAEPL IPGEPNVRVQ LAQWSPTSDA 

       310        320        330        340        350        360 
IAYVRDNNLF LRSLKHDKVV QITKDGGAEV FNGVPDWVYE EEVFSGNSAT WWSEDGNYIA 

       370        380        390        400        410        420 
YLRTNETGVP EYPVQYFLSR PSGTEPAPGE ESYPEVRQIK YPKAGAHNPV VNLKFYDVAR 

       430        440        450        460        470        480 
DESFTVEISG RFADDDRLIT EVVWAGGQVI VKETNRVSDV LRVVLVDVAA RTGKAVRELD 

       490        500        510        520        530        540 
VKAIDGGWFE ITHKTKYIPA DPSKGREQDG YIDMVIHDDN DHLAYFTPLN NSEPIMLTSG 

       550        560        570        580        590        600 
HWEVVDAPST VDLDNNIVYF VATKESSIQR HVYQVDLSGN NLKAVTDTGS EGYYDISFSA 

       610        620        630        640        650        660 
GTGYALLSYR GPNIPWQKVI STPANAHKYE HMVEENKELA KSAREYELPI KIYGTIKVDG 

       670        680        690        700        710        720 
VELNYVERRP PHFDKNKKYP VLFQQYSGPG SQSVNKRFTV DYQSYVAAGL GYVCVTVDGR 

       730        740        750        760        770        780 
GTGFIGRKNR VIIRGDLGKW EAHDQIAAAK IWASKSYVDE ERLAIWGWSF GGFNTLKTLE 

       790        800        810        820        830        840 
QDGGRTFKYG MAVAPVTDWR FYDSIYTERY MLTPQTNGHG YDTSAINNVT ALKQSVRFLM 

       850        860        870        880        890        900 
MHGVADDNVH MQNSLTLLDK LNMVGVENYD VHVFPDSDHG IYFHNANRIV YDKLTNWLIN 

       910        920 
AFNGEWIKVA NAKPQKKRSI QPILPIL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU633438 Genomic DNA. Translation: CAP60552.1.
RefSeqXP_001913070.1. XM_001913035.1.

3D structure databases

ProteinModelPortalB2A951.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6197654.
KEGGpan:PODANSg10119.

Phylogenomic databases

KOK01282.

Family and domain databases

Gene3D2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMSSF53474. SSF53474. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDAPB_PODAN
AccessionPrimary (citable) accession number: B2A951
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: May 20, 2008
Last modified: June 11, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries