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B2A951

- DAPB_PODAN

UniProt

B2A951 - DAPB_PODAN

Protein

Probable dipeptidyl-aminopeptidase B

Gene

DAPB

Organism
Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (20 May 2008)
      Previous versions | rss
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    Functioni

    Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

    Catalytic activityi

    Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei769 – 7691Charge relay systemBy similarity
    Active sitei846 – 8461Charge relay systemBy similarity
    Active sitei879 – 8791Charge relay systemBy similarity

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-KW
    2. serine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease, Serine protease

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
    Short name:
    DPAP B
    Gene namesi
    Name:DAPB
    Ordered Locus Names:PODANS_1_8430
    OrganismiPodospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
    Taxonomic identifieri515849 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesLasiosphaeriaceaePodospora
    ProteomesiUP000001197: Chromosome 1

    Subcellular locationi

    Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
    Note: Lysosome-like vacuoles.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. vacuolar membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 927927Probable dipeptidyl-aminopeptidase BPRO_0000412159Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi365 – 3651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi530 – 5301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi828 – 8281N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliB2A951.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 108108CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini130 – 927798VacuolarSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei109 – 12921Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S9B family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    KOiK01282.

    Family and domain databases

    Gene3Di2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view]
    PfamiPF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B2A951-1 [UniParc]FASTAAdd to Basket

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    MAPAPGMAPY SDEPTGPFHR PEHNDESTGR MSHESESSVS TTSIVFDRIE    50
    ERLAAKEGHF ELDDHDPMKE ADDDDNDLET GRFLGGRSST QEEDFPAKND 100
    GMNRGMRRTL IIVAGLLISA WVVGLFFYVS HKSYKPASQI EHDPQATVVQ 150
    GTGKQVTLDQ VMGSYWRAES HSISWIESPD GEDGLLLLKD GPGKDFLVVE 200
    DVRTQNSAGV NAAVDVASSR TLIKERHFDF GGQTHTPGRV WPSKDLKKVL 250
    IATNLEANWR HSFYASYWVF DVDMQIAEPL IPGEPNVRVQ LAQWSPTSDA 300
    IAYVRDNNLF LRSLKHDKVV QITKDGGAEV FNGVPDWVYE EEVFSGNSAT 350
    WWSEDGNYIA YLRTNETGVP EYPVQYFLSR PSGTEPAPGE ESYPEVRQIK 400
    YPKAGAHNPV VNLKFYDVAR DESFTVEISG RFADDDRLIT EVVWAGGQVI 450
    VKETNRVSDV LRVVLVDVAA RTGKAVRELD VKAIDGGWFE ITHKTKYIPA 500
    DPSKGREQDG YIDMVIHDDN DHLAYFTPLN NSEPIMLTSG HWEVVDAPST 550
    VDLDNNIVYF VATKESSIQR HVYQVDLSGN NLKAVTDTGS EGYYDISFSA 600
    GTGYALLSYR GPNIPWQKVI STPANAHKYE HMVEENKELA KSAREYELPI 650
    KIYGTIKVDG VELNYVERRP PHFDKNKKYP VLFQQYSGPG SQSVNKRFTV 700
    DYQSYVAAGL GYVCVTVDGR GTGFIGRKNR VIIRGDLGKW EAHDQIAAAK 750
    IWASKSYVDE ERLAIWGWSF GGFNTLKTLE QDGGRTFKYG MAVAPVTDWR 800
    FYDSIYTERY MLTPQTNGHG YDTSAINNVT ALKQSVRFLM MHGVADDNVH 850
    MQNSLTLLDK LNMVGVENYD VHVFPDSDHG IYFHNANRIV YDKLTNWLIN 900
    AFNGEWIKVA NAKPQKKRSI QPILPIL 927
    Length:927
    Mass (Da):104,169
    Last modified:May 20, 2008 - v1
    Checksum:i288D2A5A7DD9AC52
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU633438 Genomic DNA. Translation: CAP60552.1.
    RefSeqiXP_001913070.1. XM_001913035.1.

    Genome annotation databases

    GeneIDi6197654.
    KEGGipan:PODANSg10119.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU633438 Genomic DNA. Translation: CAP60552.1 .
    RefSeqi XP_001913070.1. XM_001913035.1.

    3D structure databases

    ProteinModelPortali B2A951.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 6197654.
    KEGGi pan:PODANSg10119.

    Phylogenomic databases

    KOi K01282.

    Family and domain databases

    Gene3Di 2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view ]
    Pfami PF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: S / ATCC MYA-4624 / DSM 980 / FGSC 10383.

    Entry informationi

    Entry nameiDAPB_PODAN
    AccessioniPrimary (citable) accession number: B2A951
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3