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B2A8I5 (ACKA_NATTJ) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetate kinase
EC=2.7.2.1
Alternative name(s):
Acetokinase
Gene names
Name:ackA
Ordered Locus Names:Nther_2303
OrganismNatranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF) [Complete proteome] [HAMAP]
Taxonomic identifier457570 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Natranaerobiales › Natranaerobiaceae › Natranaerobius

Protein attributes

Sequence length398 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + acetate = ADP + acetyl phosphate. HAMAP MF_00020

ATP + propanoate = ADP + propanoyl phosphate. HAMAP MF_00020

Pathway

Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. HAMAP MF_00020

Subcellular location

Cytoplasm By similarity HAMAP MF_00020.

Sequence similarities

Belongs to the acetokinase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processorganic acid metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

acetate kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 398398Acetate kinase HAMAP MF_00020
PRO_1000089985

Sequences

Sequence LengthMass (Da)Tools
B2A8I5 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: 76B9B176F4B0AC00

FASTA39843,048
        10         20         30         40         50         60 
MKILVINCGS SSLKYQVFNM ENEDVLAKGA IERIGIEGSF LKHEPAGGEE VKIEKDVTDH 

        70         80         90        100        110        120 
KAAFKMVVDA ITDEGHGVLK DLKEIEAVGH RVVHGGEEFS GSVIIDDDVM NALESCINLA 

       130        140        150        160        170        180 
PLHNPPNIYG IEASKANMPG VPQVGVFDTA FHQTMPKKAY LYGIPYEYYE KHSVRRYGFH 

       190        200        210        220        230        240 
GTSHKYVASR AADMLGKPLE DLKLITCHLG NGASVAAINK GESVDTSMGL TPLEGLVMGT 

       250        260        270        280        290        300 
RSGSMDPSII KFLMDKEGLS IDEVDNILNK KSGVLGLSGL SNDFRDLEEA AAEGNERAEN 

       310        320        330        340        350        360 
TLEVFYYTVS KYIGSYLAAL NGADAIIFTA GLGENSPSVR EAVTENLSYA GIKVDKDKNQ 

       370        380        390 
VRGKETDIST DDASTRVLVV PTNEELMIAR EAKGLLGK

« Hide

References

[1]"Complete sequence of chromosome of Natranaerobius thermophilus JW/NM-WN-LF."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Lykidis A., Mesbah N.M., Wiegel J.
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001034 Genomic DNA. Translation: ACB85869.1.
RefSeqYP_001918457.1. NC_010718.1.

3D structure databases

ProteinModelPortalB2A8I5.
SMRB2A8I5. Positions 1-396.
ModBaseSearch...

Protein-protein interaction databases

STRINGB2A8I5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6314642.
GenomeReviewsGene locus Nther_2303 in contig CP001034_GR.
KEGGnth:Nther_2303.
PATRIC22673361. VBINatThe92436_2358.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG285863.
OMAMIAREVV.

Family and domain databases

HAMAPMF_00020. Acetate_kinase.
[Tree]
InterProIPR004372. Ac/Proprionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
[Graphical view]
KOK00925.
PANTHERPTHR21060. Acetate_kin. 1 hit.
PfamPF00871. Acetate_kinase. 1 hit.
[Graphical view]
PIRSFPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSPR00471. ACETATEKNASE.
TIGRFAMsTIGR00016. AckA. 1 hit.
PROSITEPS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACKA_NATTJ
AccessionPrimary (citable) accession number: B2A8I5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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