Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acetyl-coenzyme A carboxylase carboxyl transferase subunits beta/alpha

Gene

accD

Organism
Natranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA (By similarity).By similarity

Catalytic activityi

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.
Proteins known to be involved in this subpathway in this organism are:
  1. Acetyl-coenzyme A carboxylase carboxyl transferase subunits beta/alpha (accD)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi44ZincBy similarity1
Metal bindingi47ZincBy similarity1
Metal bindingi63ZincBy similarity1
Metal bindingi66ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri44 – 66C4-typeSequence analysisAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00655; UER00711.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunits beta/alpha (EC:6.4.1.2)
Short name:
ACCase subunits beta/alpha
Short name:
Acetyl-CoA carboxylase carboxyltransferase subunits beta/alpha
Gene namesi
Name:accD
Synonyms:accA, accDA
Ordered Locus Names:Nther_0846
OrganismiNatranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF)
Taxonomic identifieri457570 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaNatranaerobialesNatranaerobiaceaeNatranaerobius
Proteomesi
  • UP000001683 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003591151 – 605Acetyl-coenzyme A carboxylase carboxyl transferase subunits beta/alphaAdd BLAST605

Proteomic databases

PRIDEiB2A865.

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterotetramer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits of ACCase subunit beta/alpha.By similarity

Protein-protein interaction databases

STRINGi457570.Nther_0846.

Structurei

3D structure databases

ProteinModelPortaliB2A865.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 306CoA carboxyltransferase N-terminalPROSITE-ProRule annotationAdd BLAST267
Domaini317 – 570CoA carboxyltransferase C-terminalPROSITE-ProRule annotationAdd BLAST254

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 269Acetyl-coenzyme A carboxylase carboxyl transferase subunit betaBy similarityAdd BLAST269
Regioni40 – 570CarboxyltransferasePROSITE-ProRule annotationAdd BLAST531
Regioni270 – 593Acetyl-coenzyme A carboxylase carboxyl transferase subunit alphaBy similarityAdd BLAST324

Sequence similaritiesi

In the N-terminal section; belongs to the AccD/PCCB family.Curated
In the C-terminal section; belongs to the AccA family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri44 – 66C4-typeSequence analysisAdd BLAST23

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG4107QTG. Bacteria.
COG0777. LUCA.
COG0825. LUCA.
HOGENOMiHOG000244564.
KOiK01962.
K01963.
OMAiAVIACEF.
OrthoDBiPOG091H04JK.

Family and domain databases

HAMAPiMF_00823. AcetylCoA_CT_alpha. 1 hit.
MF_01395. AcetylCoA_CT_beta. 1 hit.
InterProiView protein in InterPro
IPR001095. Acetyl_CoA_COase_a_su.
IPR000438. Acetyl_CoA_COase_Trfase_b_su.
IPR029045. ClpP/crotonase-like_dom.
IPR011763. COA_CT_C.
IPR011762. COA_CT_N.
PANTHERiPTHR42853. PTHR42853. 1 hit.
PfamiView protein in Pfam
PF03255. ACCA. 1 hit.
PRINTSiPR01069. ACCCTRFRASEA.
SUPFAMiSSF52096. SSF52096. 2 hits.
TIGRFAMsiTIGR00513. accA. 1 hit.
TIGR00515. accD. 1 hit.
PROSITEiView protein in PROSITE
PS50989. COA_CT_CTER. 1 hit.
PS50980. COA_CT_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

B2A865-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKGLFKKTK YISLNPERKT ELRSDQNDNK SNKPHIPDGL WEKCDSCKSI
60 70 80 90 100
IYAEDLKKNY HICHECGHHF RIGAQERINQ IIDEDTWVEL DQNIISENPL
110 120 130 140 150
EFEGYSEKVD KLQKKTELKE AILTGLGKIN GQQAVIGAMD SRFLMGSMGS
160 170 180 190 200
VVGEKVTRAI ETGIDENLPV IMFTASGGAR MQEGIYSLMQ MAKTSAAISK
210 220 230 240 250
LKDKGLPYIV VLTDPTTGGV TASFAMLGDI ILAEPNALIG FAGKRVIEQT
260 270 280 290 300
IKQKLPKEFQ RAEFLLKHGF VDKVINRKEM RNKLSHILKL HKTKQPSRML
310 320 330 340 350
DGNDCSYYSS KDASKKASAK SVEEIRQQGK KLTPYDKVKL VRSKERPTSL
360 370 380 390 400
DYIDNIFEGF IEFHGDRYFA DDTSIVGGLA FLNGLPVTVI GQQKGRDLQE
410 420 430 440 450
NIYRNFGMPN PEGYRKAVRL MQQAEKFNRP IINFVDTSGA GCGKGAEERG
460 470 480 490 500
QGEAIAQNLY TMSSLKVPII SLVIGEGGSG GALALTVADE VWMLENSVYS
510 520 530 540 550
IVSPEGFASI LWKDSSKAKE AADVMKITAQ DLQELQIIDK ILEEPYQDAS
560 570 580 590 600
KDGQAMSEII KNNLLKTLDN LSKKETNDLL TKRYEKFRSI GRFIEKSNLD

SSINQ
Length:605
Mass (Da):67,608
Last modified:May 20, 2008 - v1
Checksum:iE146C7C08BE9153C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001034 Genomic DNA. Translation: ACB84431.1.
RefSeqiWP_012447309.1. NC_010718.1.

Genome annotation databases

EnsemblBacteriaiACB84431; ACB84431; Nther_0846.
KEGGinth:Nther_0846.

Similar proteinsi

Entry informationi

Entry nameiACCDA_NATTJ
AccessioniPrimary (citable) accession number: B2A865
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: May 20, 2008
Last modified: June 7, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families