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Protein

60 kDa chaperonin

Gene

groL

Organism
Natranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperoninUniRule annotation
Alternative name(s):
GroEL proteinUniRule annotation
Protein Cpn60UniRule annotation
Gene namesi
Name:groLUniRule annotation
Synonyms:groELUniRule annotation
Ordered Locus Names:Nther_0450
OrganismiNatranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF)
Taxonomic identifieri457570 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaNatranaerobialesNatranaerobiaceaeNatranaerobius
Proteomesi
  • UP000001683 Componenti: Chromosome

Subcellular locationi

B2A5V3:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001300391 – 54860 kDa chaperoninAdd BLAST548

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

Protein-protein interaction databases

STRINGi457570.Nther_0450.

Structurei

3D structure databases

ProteinModelPortaliB2A5V3.
SMRiB2A5V3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ9. Bacteria.
COG0459. LUCA.
HOGENOMiHOG000076290.
KOiK04077.
OMAiTDTDKME.
OrthoDBiPOG091H00E7.

Family and domain databases

CDDicd03344. GroEL. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiView protein in InterPro
IPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
PANTHERiPTHR11353. PTHR11353. 1 hit.
PfamiView protein in Pfam
PF00118. Cpn60_TCP1. 1 hit.
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiView protein in PROSITE
PS00296. CHAPERONINS_CPN60. 1 hit.

Sequencei

Sequence statusi: Complete.

B2A5V3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKDIKFRED ARARLEQGVN KLADTLKVTL GPKGRNVVLD KKFGSPQITN
60 70 80 90 100
DGVTIARDID LEDNYENMGA QLVKEVATQT NDVAGDGTTT ATILAQAMVN
110 120 130 140 150
EGIKNVTAGA NPMIIRKGIQ KAVDRAVEEL QKNAVSVEDK ESISQVASIS
160 170 180 190 200
ANDEEVGKLI AEAMEKVGKD GVITVEESKS FKTDLNVVEG MQFDRGYVSP
210 220 230 240 250
YMVTDNEKME AHLEEPYILI TDKKIGNIQE ILPVLEKIVE QGKEVLLIAE
260 270 280 290 300
DIEGEALATL VVNKLRGTFT CVGVKAPGFG DRRKAMLEDI AVLTGGQVIS
310 320 330 340 350
EDVGLELKNA DISMLGRARQ VTITKDDTTI VDGYGNEEDI QKRITQLRTQ
360 370 380 390 400
IEETTSDFDR EKLEERLAKL AGGVAVVEVG AATETEMKEK KLRIEDALNS
410 420 430 440 450
TRAAVEEGIV AGGGTALIDV LPSLEEVQAD GDESTGVSIV RRALEEPVRQ
460 470 480 490 500
LAHNSGAEGS IVAEQVKQKG TNIGFNALEN DYTNMLDAGV VDPKKVTRSA
510 520 530 540
LENAGSIAAM FLTTEAVVAD LPDEDDNDDG DMGGGAPGMG GMGGMPGM
Length:548
Mass (Da):58,678
Last modified:May 20, 2008 - v1
Checksum:i299C4EB8E379CE19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001034 Genomic DNA. Translation: ACB84046.1.
RefSeqiWP_012446933.1. NC_010718.1.

Genome annotation databases

EnsemblBacteriaiACB84046; ACB84046; Nther_0450.
KEGGinth:Nther_0450.

Similar proteinsi

Entry informationi

Entry nameiCH60_NATTJ
AccessioniPrimary (citable) accession number: B2A5V3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 20, 2008
Last modified: October 25, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families