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B2A571

- B2A571_NATTJ

UniProt

B2A571 - B2A571_NATTJ

Protein

Alanine racemase

Gene

Nther_0307

Organism
Natranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (20 May 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei40 – 401Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei138 – 1381SubstrateUniRule annotation
    Active sitei267 – 2671Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei315 – 3151Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciNTHE457570:GHRL-333-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:Nther_0307Imported
    OrganismiNatranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF)Imported
    Taxonomic identifieri457570 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaNatranaerobialesNatranaerobiaceaeNatranaerobius
    ProteomesiUP000001683: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei40 – 401N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi457570.Nther_0307.

    Structurei

    3D structure databases

    ProteinModelPortaliB2A571.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0787.
    HOGENOMiHOG000031444.
    KOiK01775.
    OMAiLWQLEAI.
    OrthoDBiEOG6PP9NJ.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2A571-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSESIPVRPT FSEINLDNLS YNFNRIREHV NNKKIMGIIK ADGYGHGAVE    50
    IAEELLNQGV DYLGVAILDE AVELRKAGIA APILILGYTP VEHVDVCLKY 100
    GITPTIYTYE MAEALSQTAR KMGKTAFVHV KIDTGMGRIG IAPENSAEFV 150
    KNISKLPSLE VEGVFTHFSV ADEEDKTYTQ QQINSFEKAL KMLEDEGIEI 200
    PLKHAANSPA TIDLPDAYFD MVRVGLALFG LYPSPHMKEK ISLKPVMSLK 250
    TQVSHVKQVP KGTSISYGRK FITEDESIIG TLPVGYADGF TRLLSNIGEV 300
    IVNGKRVPIV GAICMDQCMF LGDDVPEIGI GDEVVIIGEQ DGTQITVEDI 350
    ADKLGTINYE IVTMVDKRVP RLYLKNGKLI KKKSLNSKMY 390
    Length:390
    Mass (Da):43,000
    Last modified:May 20, 2008 - v1
    Checksum:i8480BEDCC77C1B9F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001034 Genomic DNA. Translation: ACB83905.1.
    RefSeqiWP_012446793.1. NC_010718.1.
    YP_001916493.1. NC_010718.1.

    Genome annotation databases

    EnsemblBacteriaiACB83905; ACB83905; Nther_0307.
    GeneIDi6316140.
    KEGGinth:Nther_0307.
    PATRICi22669232. VBINatThe92436_0326.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001034 Genomic DNA. Translation: ACB83905.1 .
    RefSeqi WP_012446793.1. NC_010718.1.
    YP_001916493.1. NC_010718.1.

    3D structure databases

    ProteinModelPortali B2A571.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 457570.Nther_0307.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACB83905 ; ACB83905 ; Nther_0307 .
    GeneIDi 6316140.
    KEGGi nth:Nther_0307.
    PATRICi 22669232. VBINatThe92436_0326.

    Phylogenomic databases

    eggNOGi COG0787.
    HOGENOMi HOG000031444.
    KOi K01775.
    OMAi LWQLEAI.
    OrthoDBi EOG6PP9NJ.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci NTHE457570:GHRL-333-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Natranaerobius thermophilus JW/NM-WN-LF."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.
      , Kyrpides N., Lykidis A., Mesbah N.M., Wiegel J.
      Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LFImported.

    Entry informationi

    Entry nameiB2A571_NATTJ
    AccessioniPrimary (citable) accession number: B2A571
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 20, 2008
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3