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B2A531

- EX7L_NATTJ

UniProt

B2A531 - EX7L_NATTJ

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Protein

Exodeoxyribonuclease 7 large subunit

Gene

xseA

Organism
Natranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.UniRule annotation

Catalytic activityi

Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.UniRule annotation

GO - Molecular functioni

  1. exodeoxyribonuclease VII activity Source: UniProtKB-HAMAP
  2. nucleic acid binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Enzyme and pathway databases

BioCyciNTHE457570:GHRL-1740-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Exodeoxyribonuclease 7 large subunitUniRule annotation (EC:3.1.11.6UniRule annotation)
Alternative name(s):
Exodeoxyribonuclease VII large subunitUniRule annotation
Short name:
Exonuclease VII large subunitUniRule annotation
Gene namesi
Name:xseAUniRule annotation
Ordered Locus Names:Nther_1699
OrganismiNatranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF)
Taxonomic identifieri457570 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaNatranaerobialesNatranaerobiaceaeNatranaerobius
ProteomesiUP000001683: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
  2. exodeoxyribonuclease VII complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 423423Exodeoxyribonuclease 7 large subunitPRO_1000122074Add
BLAST

Interactioni

Subunit structurei

Heterooligomer composed of large and small subunits.UniRule annotation

Protein-protein interaction databases

STRINGi457570.Nther_1699.

Family & Domainsi

Sequence similaritiesi

Belongs to the XseA family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1570.
HOGENOMiHOG000229265.
KOiK03601.
OMAiSKINCIM.
OrthoDBiEOG64R65J.

Family and domain databases

HAMAPiMF_00378. Exonuc_7_L.
InterProiIPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR025824. OB-fold_nuc-bd_dom.
[Graphical view]
PfamiPF02601. Exonuc_VII_L. 2 hits.
PF13742. tRNA_anti_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00237. xseA. 1 hit.

Sequencei

Sequence statusi: Complete.

B2A531-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSERTVTVSQ LTNYLKNLLL QDHNLKNVLV RGEISNFKHH SSGHMYFTLK
60 70 80 90 100
DEGASLRCVM FRNRNWNLDF SPQDGMDVIV QGVVGIFERA GLYQLYVEKM
110 120 130 140 150
YSHGLGSLHL AFEQLKEKLA EEGIFNEEYK KTLPPFPKKI AVVTSPTGAA
160 170 180 190 200
VRDMIVTISR RFPLTSILLI PVRVQGEYAA SEIRAGIDYA NSIDDIDVIL
210 220 230 240 250
VGRGGGSLEE IWPFNTEEVA RAIFSSKAPV ISCVGHETDF TISDFVSDLR
260 270 280 290 300
APTPTAAAEL VVPDQVELKR QVSDYKHRLT KALYHKYRNL DQRVVELLDR
310 320 330 340 350
PVMKNPYTLI SERKKELEYL DQRLLREVYH LFKLKRNKYS SLVEQLDSLS
360 370 380 390 400
PLKTLGRGYT FCQTHDGDIV RSVTDIEQED ILKLTFFDGS AKCLVKEKQE
410 420
HHISEDHSNL NSLCNEEEDY DRQ
Length:423
Mass (Da):48,390
Last modified:May 20, 2008 - v1
Checksum:iA9E44D468BAC3B4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001034 Genomic DNA. Translation: ACB85273.1.
RefSeqiWP_012448141.1. NC_010718.1.
YP_001917861.1. NC_010718.1.

Genome annotation databases

EnsemblBacteriaiACB85273; ACB85273; Nther_1699.
GeneIDi6317043.
KEGGinth:Nther_1699.
PATRICi22672092. VBINatThe92436_1743.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001034 Genomic DNA. Translation: ACB85273.1 .
RefSeqi WP_012448141.1. NC_010718.1.
YP_001917861.1. NC_010718.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 457570.Nther_1699.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACB85273 ; ACB85273 ; Nther_1699 .
GeneIDi 6317043.
KEGGi nth:Nther_1699.
PATRICi 22672092. VBINatThe92436_1743.

Phylogenomic databases

eggNOGi COG1570.
HOGENOMi HOG000229265.
KOi K03601.
OMAi SKINCIM.
OrthoDBi EOG64R65J.

Enzyme and pathway databases

BioCyci NTHE457570:GHRL-1740-MONOMER.

Family and domain databases

HAMAPi MF_00378. Exonuc_7_L.
InterProi IPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR025824. OB-fold_nuc-bd_dom.
[Graphical view ]
Pfami PF02601. Exonuc_VII_L. 2 hits.
PF13742. tRNA_anti_2. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00237. xseA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Natranaerobius thermophilus JW/NM-WN-LF."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.
    , Kyrpides N., Lykidis A., Mesbah N.M., Wiegel J.
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF.

Entry informationi

Entry nameiEX7L_NATTJ
AccessioniPrimary (citable) accession number: B2A531
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 20, 2008
Last modified: November 26, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3