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B2A531

- EX7L_NATTJ

UniProt

B2A531 - EX7L_NATTJ

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Protein
Exodeoxyribonuclease 7 large subunit
Gene
xseA, Nther_1699
Organism
Natranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides By similarity.UniRule annotation

Catalytic activityi

Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.UniRule annotation

GO - Molecular functioni

  1. exodeoxyribonuclease VII activity Source: UniProtKB-HAMAP
  2. nucleic acid binding Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Exonuclease, Hydrolase, Nuclease

    Enzyme and pathway databases

    BioCyciNTHE457570:GHRL-1740-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Exodeoxyribonuclease 7 large subunit (EC:3.1.11.6)
    Alternative name(s):
    Exodeoxyribonuclease VII large subunit
    Short name:
    Exonuclease VII large subunit
    Gene namesi
    Name:xseA
    Ordered Locus Names:Nther_1699
    OrganismiNatranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF)
    Taxonomic identifieri457570 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaNatranaerobialesNatranaerobiaceaeNatranaerobius
    ProteomesiUP000001683: Chromosome

    Subcellular locationi

    Cytoplasm By similarity UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. exodeoxyribonuclease VII complex Source: InterPro
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 423423Exodeoxyribonuclease 7 large subunitUniRule annotation
    PRO_1000122074Add
    BLAST

    Interactioni

    Subunit structurei

    Heterooligomer composed of large and small subunits By similarity.

    Protein-protein interaction databases

    STRINGi457570.Nther_1699.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the XseA family.

    Phylogenomic databases

    eggNOGiCOG1570.
    HOGENOMiHOG000229265.
    KOiK03601.
    OMAiSKINCIM.
    OrthoDBiEOG64R65J.

    Family and domain databases

    HAMAPiMF_00378. Exonuc_7_L.
    InterProiIPR003753. Exonuc_VII_L.
    IPR020579. Exonuc_VII_lsu_C.
    IPR025824. OB-fold_nuc-bd_dom.
    [Graphical view]
    PfamiPF02601. Exonuc_VII_L. 2 hits.
    PF13742. tRNA_anti_2. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00237. xseA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B2A531-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSERTVTVSQ LTNYLKNLLL QDHNLKNVLV RGEISNFKHH SSGHMYFTLK    50
    DEGASLRCVM FRNRNWNLDF SPQDGMDVIV QGVVGIFERA GLYQLYVEKM 100
    YSHGLGSLHL AFEQLKEKLA EEGIFNEEYK KTLPPFPKKI AVVTSPTGAA 150
    VRDMIVTISR RFPLTSILLI PVRVQGEYAA SEIRAGIDYA NSIDDIDVIL 200
    VGRGGGSLEE IWPFNTEEVA RAIFSSKAPV ISCVGHETDF TISDFVSDLR 250
    APTPTAAAEL VVPDQVELKR QVSDYKHRLT KALYHKYRNL DQRVVELLDR 300
    PVMKNPYTLI SERKKELEYL DQRLLREVYH LFKLKRNKYS SLVEQLDSLS 350
    PLKTLGRGYT FCQTHDGDIV RSVTDIEQED ILKLTFFDGS AKCLVKEKQE 400
    HHISEDHSNL NSLCNEEEDY DRQ 423
    Length:423
    Mass (Da):48,390
    Last modified:May 20, 2008 - v1
    Checksum:iA9E44D468BAC3B4D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001034 Genomic DNA. Translation: ACB85273.1.
    RefSeqiYP_001917861.1. NC_010718.1.

    Genome annotation databases

    EnsemblBacteriaiACB85273; ACB85273; Nther_1699.
    GeneIDi6317043.
    KEGGinth:Nther_1699.
    PATRICi22672092. VBINatThe92436_1743.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001034 Genomic DNA. Translation: ACB85273.1 .
    RefSeqi YP_001917861.1. NC_010718.1.

    3D structure databases

    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 457570.Nther_1699.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACB85273 ; ACB85273 ; Nther_1699 .
    GeneIDi 6317043.
    KEGGi nth:Nther_1699.
    PATRICi 22672092. VBINatThe92436_1743.

    Phylogenomic databases

    eggNOGi COG1570.
    HOGENOMi HOG000229265.
    KOi K03601.
    OMAi SKINCIM.
    OrthoDBi EOG64R65J.

    Enzyme and pathway databases

    BioCyci NTHE457570:GHRL-1740-MONOMER.

    Family and domain databases

    HAMAPi MF_00378. Exonuc_7_L.
    InterProi IPR003753. Exonuc_VII_L.
    IPR020579. Exonuc_VII_lsu_C.
    IPR025824. OB-fold_nuc-bd_dom.
    [Graphical view ]
    Pfami PF02601. Exonuc_VII_L. 2 hits.
    PF13742. tRNA_anti_2. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00237. xseA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Natranaerobius thermophilus JW/NM-WN-LF."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.
      , Kyrpides N., Lykidis A., Mesbah N.M., Wiegel J.
      Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF.

    Entry informationi

    Entry nameiEX7L_NATTJ
    AccessioniPrimary (citable) accession number: B2A531
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: May 20, 2008
    Last modified: May 14, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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