Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

B2A531 (EX7L_NATTJ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Exodeoxyribonuclease 7 large subunit

EC=3.1.11.6
Alternative name(s):
Exodeoxyribonuclease VII large subunit
Short name=Exonuclease VII large subunit
Gene names
Name:xseA
Ordered Locus Names:Nther_1699
OrganismNatranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF) [Complete proteome] [HAMAP]
Taxonomic identifier457570 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaNatranaerobialesNatranaerobiaceaeNatranaerobius

Protein attributes

Sequence length423 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides By similarity. HAMAP-Rule MF_00378

Catalytic activity

Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates. HAMAP-Rule MF_00378

Subunit structure

Heterooligomer composed of large and small subunits By similarity.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00378.

Sequence similarities

Belongs to the XseA family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionExonuclease
Hydrolase
Nuclease
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

exodeoxyribonuclease VII complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionexodeoxyribonuclease VII activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

nucleic acid binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 423423Exodeoxyribonuclease 7 large subunit HAMAP-Rule MF_00378
PRO_1000122074

Sequences

Sequence LengthMass (Da)Tools
B2A531 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: A9E44D468BAC3B4D

FASTA42348,390
        10         20         30         40         50         60 
MSERTVTVSQ LTNYLKNLLL QDHNLKNVLV RGEISNFKHH SSGHMYFTLK DEGASLRCVM 

        70         80         90        100        110        120 
FRNRNWNLDF SPQDGMDVIV QGVVGIFERA GLYQLYVEKM YSHGLGSLHL AFEQLKEKLA 

       130        140        150        160        170        180 
EEGIFNEEYK KTLPPFPKKI AVVTSPTGAA VRDMIVTISR RFPLTSILLI PVRVQGEYAA 

       190        200        210        220        230        240 
SEIRAGIDYA NSIDDIDVIL VGRGGGSLEE IWPFNTEEVA RAIFSSKAPV ISCVGHETDF 

       250        260        270        280        290        300 
TISDFVSDLR APTPTAAAEL VVPDQVELKR QVSDYKHRLT KALYHKYRNL DQRVVELLDR 

       310        320        330        340        350        360 
PVMKNPYTLI SERKKELEYL DQRLLREVYH LFKLKRNKYS SLVEQLDSLS PLKTLGRGYT 

       370        380        390        400        410        420 
FCQTHDGDIV RSVTDIEQED ILKLTFFDGS AKCLVKEKQE HHISEDHSNL NSLCNEEEDY 


DRQ 

« Hide

References

[1]"Complete sequence of chromosome of Natranaerobius thermophilus JW/NM-WN-LF."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Lykidis A., Mesbah N.M., Wiegel J.
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001034 Genomic DNA. Translation: ACB85273.1.
RefSeqYP_001917861.1. NC_010718.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING457570.Nther_1699.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACB85273; ACB85273; Nther_1699.
GeneID6317043.
KEGGnth:Nther_1699.
PATRIC22672092. VBINatThe92436_1743.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1570.
HOGENOMHOG000229265.
KOK03601.
OMASKINCIM.
OrthoDBEOG64R65J.

Enzyme and pathway databases

BioCycNTHE457570:GHRL-1740-MONOMER.

Family and domain databases

HAMAPMF_00378. Exonuc_7_L.
InterProIPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR025824. OB-fold_nuc-bd_dom.
[Graphical view]
PfamPF02601. Exonuc_VII_L. 2 hits.
PF13742. tRNA_anti_2. 1 hit.
[Graphical view]
TIGRFAMsTIGR00237. xseA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameEX7L_NATTJ
AccessionPrimary (citable) accession number: B2A531
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 20, 2008
Last modified: May 14, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families