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Protein

NAD kinase

Gene

nadK

Organism
Natranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei68Proton acceptorUniRule annotation1
Binding sitei73NADUniRule annotation1
Binding sitei153NADUniRule annotation1
Binding sitei172NADUniRule annotation1
Binding sitei242NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi68 – 69NADUniRule annotation2
Nucleotide bindingi142 – 143NADUniRule annotation2
Nucleotide bindingi183 – 188NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Nther_1692
OrganismiNatranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF)
Taxonomic identifieri457570 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaNatranaerobialesNatranaerobiaceaeNatranaerobius
Proteomesi
  • UP000001683 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001208731 – 286NAD kinaseAdd BLAST286

Interactioni

Protein-protein interaction databases

STRINGi457570.Nther_1692

Structurei

3D structure databases

ProteinModelPortaliB2A524
SMRiB2A524
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
HOGENOMiHOG000227222
KOiK00858
OMAiVNLGHVG
OrthoDBiPOG091H02D1

Family and domain databases

Gene3Di2.60.200.301 hit
3.40.50.103302 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

B2A524-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSVGLIPNI QKDQVAEITS RMYKILSEHD IDVYLTHEGA DLIGTESAGV
60 70 80 90 100
SSDVMGEVAE MIIILGGDGT ILKAAREYAP YDIPLLGINL GKMGFLAEIE
110 120 130 140 150
ANEVMAYLES LLTGNYTIEE RMMLDATVLR DRKEITTFSA LNDVIIAKGP
160 170 180 190 200
FSRIIEVETK VGGNYLETYP GDGLIVTSPT GSTGYSFSAG GPIISSNLEV
210 220 230 240 250
MMITPICPHL MHNRSVIISS DEVVTAKMKT NYAVVVLTVD GQQGFTLQDG
260 270 280
DEIKVKKSNY KTKLVKLRRR SFYQLLNEKL TGGQEV
Length:286
Mass (Da):31,323
Last modified:May 20, 2008 - v1
Checksum:i49FCE0753D2BB4BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001034 Genomic DNA Translation: ACB85266.1
RefSeqiWP_012448134.1, NC_010718.1

Genome annotation databases

EnsemblBacteriaiACB85266; ACB85266; Nther_1692
KEGGinth:Nther_1692

Similar proteinsi

Entry informationi

Entry nameiNADK_NATTJ
AccessioniPrimary (citable) accession number: B2A524
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 20, 2008
Last modified: February 28, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome