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B2A524

- NADK_NATTJ

UniProt

B2A524 - NADK_NATTJ

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Protein

NAD kinase

Gene

nadK

Organism
Natranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei68 – 681Proton acceptorUniRule annotation
Binding sitei73 – 731NADUniRule annotation
Binding sitei153 – 1531NADUniRule annotation
Binding sitei172 – 1721NADUniRule annotation
Binding sitei242 – 2421NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi68 – 692NADUniRule annotation
Nucleotide bindingi142 – 1432NADUniRule annotation
Nucleotide bindingi183 – 1886NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciNTHE457570:GHRL-1733-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Nther_1692
OrganismiNatranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF)
Taxonomic identifieri457570 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaNatranaerobialesNatranaerobiaceaeNatranaerobius
ProteomesiUP000001683: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 286286NAD kinasePRO_1000120873Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi457570.Nther_1692.

Structurei

3D structure databases

ProteinModelPortaliB2A524.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227222.
KOiK00858.
OMAiTHEMLYH.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

B2A524 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRSVGLIPNI QKDQVAEITS RMYKILSEHD IDVYLTHEGA DLIGTESAGV
60 70 80 90 100
SSDVMGEVAE MIIILGGDGT ILKAAREYAP YDIPLLGINL GKMGFLAEIE
110 120 130 140 150
ANEVMAYLES LLTGNYTIEE RMMLDATVLR DRKEITTFSA LNDVIIAKGP
160 170 180 190 200
FSRIIEVETK VGGNYLETYP GDGLIVTSPT GSTGYSFSAG GPIISSNLEV
210 220 230 240 250
MMITPICPHL MHNRSVIISS DEVVTAKMKT NYAVVVLTVD GQQGFTLQDG
260 270 280
DEIKVKKSNY KTKLVKLRRR SFYQLLNEKL TGGQEV
Length:286
Mass (Da):31,323
Last modified:May 20, 2008 - v1
Checksum:i49FCE0753D2BB4BA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001034 Genomic DNA. Translation: ACB85266.1.
RefSeqiWP_012448134.1. NC_010718.1.
YP_001917854.1. NC_010718.1.

Genome annotation databases

EnsemblBacteriaiACB85266; ACB85266; Nther_1692.
GeneIDi6314335.
KEGGinth:Nther_1692.
PATRICi22672078. VBINatThe92436_1736.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001034 Genomic DNA. Translation: ACB85266.1 .
RefSeqi WP_012448134.1. NC_010718.1.
YP_001917854.1. NC_010718.1.

3D structure databases

ProteinModelPortali B2A524.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 457570.Nther_1692.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACB85266 ; ACB85266 ; Nther_1692 .
GeneIDi 6314335.
KEGGi nth:Nther_1692.
PATRICi 22672078. VBINatThe92436_1736.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227222.
KOi K00858.
OMAi THEMLYH.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci NTHE457570:GHRL-1733-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Natranaerobius thermophilus JW/NM-WN-LF."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.
    , Kyrpides N., Lykidis A., Mesbah N.M., Wiegel J.
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF.

Entry informationi

Entry nameiNADK_NATTJ
AccessioniPrimary (citable) accession number: B2A524
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 20, 2008
Last modified: October 29, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3