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B2A4X5

- GLSA_NATTJ

UniProt

B2A4X5 - GLSA_NATTJ

Protein

Glutaminase

Gene

glsA

Organism
Natranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (20 May 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei66 – 661SubstrateUniRule annotation
    Binding sitei117 – 1171SubstrateUniRule annotation
    Binding sitei162 – 1621SubstrateUniRule annotation
    Binding sitei169 – 1691SubstrateUniRule annotation
    Binding sitei193 – 1931SubstrateUniRule annotation
    Binding sitei244 – 2441SubstrateUniRule annotation
    Binding sitei262 – 2621Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. glutaminase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glutamine metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciNTHE457570:GHRL-325-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GlutaminaseUniRule annotation (EC:3.5.1.2UniRule annotation)
    Gene namesi
    Name:glsAUniRule annotation
    Ordered Locus Names:Nther_0299
    OrganismiNatranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF)
    Taxonomic identifieri457570 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaNatranaerobialesNatranaerobiaceaeNatranaerobius
    ProteomesiUP000001683: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 308308GlutaminasePRO_1000132909Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi457570.Nther_0299.

    Structurei

    3D structure databases

    ProteinModelPortaliB2A4X5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutaminase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2066.
    HOGENOMiHOG000216890.
    KOiK01425.
    OMAiQRARRIN.
    OrthoDBiEOG6N94BK.

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    HAMAPiMF_00313. Glutaminase.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR015868. Glutaminase.
    [Graphical view]
    PANTHERiPTHR12544. PTHR12544. 1 hit.
    PfamiPF04960. Glutaminase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56601. SSF56601. 1 hit.
    TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B2A4X5-1 [UniParc]FASTAAdd to Basket

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    MINNVNQEIL RAFVENNRPL AHDGRLPTYI PALMNANKQD FGIHITELDG    50
    NSHYYGSFQI PFTVQSISKI ITLAMAIMDN GEELVFSRVG MEPTEDKFNS 100
    ILPLEMSSAY PPNPMINAGA IVVTSLIKGR TAGEQFERIL DFTRALADNK 150
    NIQVDENAFL SERETGNMNR SLAYYLKDAN VINGNVEEIL ETYFRHCSIL 200
    VTAEDLSRIA YIFANDGKDI EGKQLIPAKV CKIVRAIMAM SGFYDESGEF 250
    AVRVGIPAKS GVGGGIIGVV PGYMGIGLYG PALNNKGTSI VGFNVLEELT 300
    SYLQVGIY 308
    Length:308
    Mass (Da):33,820
    Last modified:May 20, 2008 - v1
    Checksum:iAB01FAB6E85734C3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001034 Genomic DNA. Translation: ACB83897.1.
    RefSeqiWP_012446785.1. NC_010718.1.
    YP_001916485.1. NC_010718.1.

    Genome annotation databases

    EnsemblBacteriaiACB83897; ACB83897; Nther_0299.
    GeneIDi6316121.
    KEGGinth:Nther_0299.
    PATRICi22669216. VBINatThe92436_0318.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001034 Genomic DNA. Translation: ACB83897.1 .
    RefSeqi WP_012446785.1. NC_010718.1.
    YP_001916485.1. NC_010718.1.

    3D structure databases

    ProteinModelPortali B2A4X5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 457570.Nther_0299.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACB83897 ; ACB83897 ; Nther_0299 .
    GeneIDi 6316121.
    KEGGi nth:Nther_0299.
    PATRICi 22669216. VBINatThe92436_0318.

    Phylogenomic databases

    eggNOGi COG2066.
    HOGENOMi HOG000216890.
    KOi K01425.
    OMAi QRARRIN.
    OrthoDBi EOG6N94BK.

    Enzyme and pathway databases

    BioCyci NTHE457570:GHRL-325-MONOMER.

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    HAMAPi MF_00313. Glutaminase.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR015868. Glutaminase.
    [Graphical view ]
    PANTHERi PTHR12544. PTHR12544. 1 hit.
    Pfami PF04960. Glutaminase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56601. SSF56601. 1 hit.
    TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Natranaerobius thermophilus JW/NM-WN-LF."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.
      , Kyrpides N., Lykidis A., Mesbah N.M., Wiegel J.
      Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF.

    Entry informationi

    Entry nameiGLSA_NATTJ
    AccessioniPrimary (citable) accession number: B2A4X5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3