B2A4R9 (GLMM_NATTJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoglucosamine mutase
EC=5.4.2.10

Gene names

Name:	glmM
Ordered Locus Names:	Nther_0242

Organism

Natranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF) [Complete proteome] [HAMAP]

Taxonomic identifier

457570 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Natranaerobiales › Natranaerobiaceae › Natranaerobius

Protein attributes

Sequence length	442 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate By similarity. HAMAP MF_01554_B
Catalytic activity	Alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate. HAMAP MF_01554_B
Cofactor	Binds 1 magnesium ion per subunit By similarity. HAMAP MF_01554_B
Post-translational modification	Activated by phosphorylation By similarity. HAMAP MF_01554_B
Sequence similarities	Belongs to the phosphohexose mutase family.

Ontologies

Keywords
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: InterPro phosphoglucosamine mutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 442	442	Phosphoglucosamine mutase HAMAP MF_01554_B		PRO_1000201121
Sites
	Active site	98	1	Phosphoserine intermediate By similarity
	Metal binding	98	1	Magnesium; via phosphate group By similarity
	Metal binding	236	1	Magnesium By similarity
	Metal binding	238	1	Magnesium By similarity
	Metal binding	240	1	Magnesium By similarity
Amino acid modifications
	Modified residue	98	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	B2A4R9 [UniParc]. Last modified May 20, 2008. Version 1. Checksum: A2C8F93EF7A381F6	FASTA	442	48,032
	10 20 30 40 50 60 MPKLFGTDGV RGVANEDLTP ELCLKIGRAA GEYLKSYGDT VLVGRDTRLS GTMLEAALSA 70 80 90 100 110 120 GLASVGLKVE RLGIVTTPAV AFLASREDVA GGAMISASHN PVPDNGVKFF DNKGYKLAES 130 140 150 160 170 180 HEEQIENYLE KELSRPTGTD IGKVLPENNK LIENYIQELI DKYPLDLSNY KIVLDCAYGA 190 200 210 220 230 240 TYQIAPRLFK KLGAEIIPLH AENRGEKINV ECGSTNPELT SRTVVEEGAD LGFSFDGDGD 250 260 270 280 290 300 RIIALDEEGN QVNGDKIMAI LAKDMKSRGE LKNDKLIATV MSNLGLKLAL KELGIALEET 310 320 330 340 350 360 KVGDRNVLNR MREQDCVLGG EQSGHIINLQ DNTTGDGVLT GLKLMKVLID TGQSLKQLAS 370 380 390 400 410 420 IMEELPQLLV NVKVSNKDSA INSQKVQEEK SKVEKQLGSK GRVLIRPSGT EPVIRVMVEG 430 440 ENRETLHEVA NHLTQVIKKA AE

References

[1]

"Complete sequence of chromosome of Natranaerobius thermophilus JW/NM-WN-LF." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Lykidis A., Mesbah N.M., Wiegel J. Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001034 Genomic DNA. Translation: ACB83841.1.
RefSeq	YP_001916429.1. NC_010718.1.
3D structure databases
ProteinModelPortal	B2A4R9.
ModBase	Search...
Protein-protein interaction databases
STRING	B2A4R9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6316000.
GenomeReviews	Gene locus Nther_0242 in contig CP001034_GR.
KEGG	nth:Nther_0242.
PATRIC	22669092. VBINatThe92436_0259.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG644964.
OMA	GVGSTHL.
Family and domain databases
HAMAP	MF_01554_B. GlmM_B. [Tree]
InterPro	IPR005844. A-D-PHexomutase_a/b/a-I. IPR016055. A-D-PHexomutase_a/b/a-I/II/III. IPR005845. A-D-PHexomutase_a/b/a-II. IPR005846. A-D-PHexomutase_a/b/a-III. IPR005843. A-D-PHexomutase_C. IPR005841. Alpha-D-phosphohexomutase_SF. IPR006352. GlmM. [Graphical view]
Gene3D	G3DSA:3.40.120.10. A-D-PHexomutase_a/b/a-I/II/III. 3 hits.
KO	K03431.
Pfam	PF02878. PGM_PMM_I. 1 hit. PF02879. PGM_PMM_II. 1 hit. PF02880. PGM_PMM_III. 1 hit. PF00408. PGM_PMM_IV. 1 hit. [Graphical view]
PRINTS	PR00509. PGMPMM.
SUPFAM	SSF53738. A-D-PHexomutase_a/b/a-I/II/III. 2 hits.
TIGRFAMs	TIGR01455. GlmM. 1 hit.
PROSITE	PS00710. PGM_PMM. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLMM_NATTJ

Accession

Primary (citable) accession number: B2A4R9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	May 20, 2008
Last modified:	January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program