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B2A3Q6 (FTHS_NATTJ) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:Nther_0083
OrganismNatranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF) [Complete proteome] [HAMAP]
Taxonomic identifier457570 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaNatranaerobialesNatranaerobiaceaeNatranaerobius

Protein attributes

Sequence length556 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 556556Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_1000196818

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
B2A3Q6 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: 4DDEA3634A3794E8

FASTA55660,470
        10         20         30         40         50         60 
MKSDIEIARG APMRPIKDIA SEVGIKDEEL ELYGDYKAKI TFDAWKRLKD KPDGNLILVT 

        70         80         90        100        110        120 
AITPTPAGEG KSTTTVGLGQ ALKRLGKNTM VALREPSLGP SFGVKGGAAG GGYSQVVPME 

       130        140        150        160        170        180 
DINLHFTGDI HAITTAHNLL SAAIDNHIHQ GNNLDIDARR INWRRVVDLN DRALRNTVVA 

       190        200        210        220        230        240 
LGGRGNGFPR EDGFDITVAS EIMAILCLAT DIKDLKERLS KIIIGYTRDR QPVTVADLKM 

       250        260        270        280        290        300 
QGSMAVLLKD AIKPNLVQTY ENVPAFVHGG PFANIAHGCN SAMATQMGVK MSDYLVTEAG 

       310        320        330        340        350        360 
FGADLGAEKF FNIKCRFAGL NPDAAVVVAT ARALKMHGGV EKDNLKEENL EALEKGFENL 

       370        380        390        400        410        420 
EKHMENINKF GVPAVVAVNR FPTDTEKELE LLINKCQEKG YRVALSEVFA KGGEGGEEVA 

       430        440        450        460        470        480 
KEVLDIIDSK ESNFKYLYDV DKSMEEKIET IAKEIYGASD VEFTPTARRN IKQLAQKGLD 

       490        500        510        520        530        540 
QVPVCMAKTQ FSFSDDPKLL GRPKDFSITV KRVRISAGAG FAVAMTGDIM TMPGLPKQPA 

       550 
AEEIDIDDDG QITGLF 

« Hide

References

[1]"Complete sequence of chromosome of Natranaerobius thermophilus JW/NM-WN-LF."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Lykidis A., Mesbah N.M., Wiegel J.
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001034 Genomic DNA. Translation: ACB83682.1.
RefSeqYP_001916270.1. NC_010718.1.

3D structure databases

ProteinModelPortalB2A3Q6.
SMRB2A3Q6. Positions 4-554.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING457570.Nther_0083.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACB83682; ACB83682; Nther_0083.
GeneID6316276.
KEGGnth:Nther_0083.
PATRIC22668754. VBINatThe92436_0100.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycNTHE457570:GHRL-95-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_NATTJ
AccessionPrimary (citable) accession number: B2A3Q6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 20, 2008
Last modified: April 16, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways