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B2A3Q6

- FTHS_NATTJ

UniProt

B2A3Q6 - FTHS_NATTJ

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Natranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (20 May 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciNTHE457570:GHRL-95-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Nther_0083
    OrganismiNatranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF)
    Taxonomic identifieri457570 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaNatranaerobialesNatranaerobiaceaeNatranaerobius
    ProteomesiUP000001683: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 556556Formate--tetrahydrofolate ligasePRO_1000196818Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi457570.Nther_0083.

    Structurei

    3D structure databases

    ProteinModelPortaliB2A3Q6.
    SMRiB2A3Q6. Positions 4-554.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2A3Q6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSDIEIARG APMRPIKDIA SEVGIKDEEL ELYGDYKAKI TFDAWKRLKD    50
    KPDGNLILVT AITPTPAGEG KSTTTVGLGQ ALKRLGKNTM VALREPSLGP 100
    SFGVKGGAAG GGYSQVVPME DINLHFTGDI HAITTAHNLL SAAIDNHIHQ 150
    GNNLDIDARR INWRRVVDLN DRALRNTVVA LGGRGNGFPR EDGFDITVAS 200
    EIMAILCLAT DIKDLKERLS KIIIGYTRDR QPVTVADLKM QGSMAVLLKD 250
    AIKPNLVQTY ENVPAFVHGG PFANIAHGCN SAMATQMGVK MSDYLVTEAG 300
    FGADLGAEKF FNIKCRFAGL NPDAAVVVAT ARALKMHGGV EKDNLKEENL 350
    EALEKGFENL EKHMENINKF GVPAVVAVNR FPTDTEKELE LLINKCQEKG 400
    YRVALSEVFA KGGEGGEEVA KEVLDIIDSK ESNFKYLYDV DKSMEEKIET 450
    IAKEIYGASD VEFTPTARRN IKQLAQKGLD QVPVCMAKTQ FSFSDDPKLL 500
    GRPKDFSITV KRVRISAGAG FAVAMTGDIM TMPGLPKQPA AEEIDIDDDG 550
    QITGLF 556
    Length:556
    Mass (Da):60,470
    Last modified:May 20, 2008 - v1
    Checksum:i4DDEA3634A3794E8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001034 Genomic DNA. Translation: ACB83682.1.
    RefSeqiWP_012446573.1. NC_010718.1.
    YP_001916270.1. NC_010718.1.

    Genome annotation databases

    EnsemblBacteriaiACB83682; ACB83682; Nther_0083.
    GeneIDi6316276.
    KEGGinth:Nther_0083.
    PATRICi22668754. VBINatThe92436_0100.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001034 Genomic DNA. Translation: ACB83682.1 .
    RefSeqi WP_012446573.1. NC_010718.1.
    YP_001916270.1. NC_010718.1.

    3D structure databases

    ProteinModelPortali B2A3Q6.
    SMRi B2A3Q6. Positions 4-554.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 457570.Nther_0083.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACB83682 ; ACB83682 ; Nther_0083 .
    GeneIDi 6316276.
    KEGGi nth:Nther_0083.
    PATRICi 22668754. VBINatThe92436_0100.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci NTHE457570:GHRL-95-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Natranaerobius thermophilus JW/NM-WN-LF."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.
      , Kyrpides N., Lykidis A., Mesbah N.M., Wiegel J.
      Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF.

    Entry informationi

    Entry nameiFTHS_NATTJ
    AccessioniPrimary (citable) accession number: B2A3Q6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3