Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B2A3Q6

- FTHS_NATTJ

UniProt

B2A3Q6 - FTHS_NATTJ

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Natranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciNTHE457570:GHRL-95-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Nther_0083
OrganismiNatranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF)
Taxonomic identifieri457570 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaNatranaerobialesNatranaerobiaceaeNatranaerobius
ProteomesiUP000001683: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Formate--tetrahydrofolate ligasePRO_1000196818Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi457570.Nther_0083.

Structurei

3D structure databases

ProteinModelPortaliB2A3Q6.
SMRiB2A3Q6. Positions 4-554.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2A3Q6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKSDIEIARG APMRPIKDIA SEVGIKDEEL ELYGDYKAKI TFDAWKRLKD
60 70 80 90 100
KPDGNLILVT AITPTPAGEG KSTTTVGLGQ ALKRLGKNTM VALREPSLGP
110 120 130 140 150
SFGVKGGAAG GGYSQVVPME DINLHFTGDI HAITTAHNLL SAAIDNHIHQ
160 170 180 190 200
GNNLDIDARR INWRRVVDLN DRALRNTVVA LGGRGNGFPR EDGFDITVAS
210 220 230 240 250
EIMAILCLAT DIKDLKERLS KIIIGYTRDR QPVTVADLKM QGSMAVLLKD
260 270 280 290 300
AIKPNLVQTY ENVPAFVHGG PFANIAHGCN SAMATQMGVK MSDYLVTEAG
310 320 330 340 350
FGADLGAEKF FNIKCRFAGL NPDAAVVVAT ARALKMHGGV EKDNLKEENL
360 370 380 390 400
EALEKGFENL EKHMENINKF GVPAVVAVNR FPTDTEKELE LLINKCQEKG
410 420 430 440 450
YRVALSEVFA KGGEGGEEVA KEVLDIIDSK ESNFKYLYDV DKSMEEKIET
460 470 480 490 500
IAKEIYGASD VEFTPTARRN IKQLAQKGLD QVPVCMAKTQ FSFSDDPKLL
510 520 530 540 550
GRPKDFSITV KRVRISAGAG FAVAMTGDIM TMPGLPKQPA AEEIDIDDDG

QITGLF
Length:556
Mass (Da):60,470
Last modified:May 20, 2008 - v1
Checksum:i4DDEA3634A3794E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001034 Genomic DNA. Translation: ACB83682.1.
RefSeqiYP_001916270.1. NC_010718.1.

Genome annotation databases

EnsemblBacteriaiACB83682; ACB83682; Nther_0083.
GeneIDi6316276.
KEGGinth:Nther_0083.
PATRICi22668754. VBINatThe92436_0100.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001034 Genomic DNA. Translation: ACB83682.1 .
RefSeqi YP_001916270.1. NC_010718.1.

3D structure databases

ProteinModelPortali B2A3Q6.
SMRi B2A3Q6. Positions 4-554.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 457570.Nther_0083.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACB83682 ; ACB83682 ; Nther_0083 .
GeneIDi 6316276.
KEGGi nth:Nther_0083.
PATRICi 22668754. VBINatThe92436_0100.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci NTHE457570:GHRL-95-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Natranaerobius thermophilus JW/NM-WN-LF."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.
    , Kyrpides N., Lykidis A., Mesbah N.M., Wiegel J.
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF.

Entry informationi

Entry nameiFTHS_NATTJ
AccessioniPrimary (citable) accession number: B2A3Q6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 20, 2008
Last modified: November 26, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3