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B2A3Q6

- FTHS_NATTJ

UniProt

B2A3Q6 - FTHS_NATTJ

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, Nther_0083
Organism
Natranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciNTHE457570:GHRL-95-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:Nther_0083
OrganismiNatranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF)
Taxonomic identifieri457570 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaNatranaerobialesNatranaerobiaceaeNatranaerobius
ProteomesiUP000001683: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Formate--tetrahydrofolate ligaseUniRule annotation
PRO_1000196818Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi457570.Nther_0083.

Structurei

3D structure databases

ProteinModelPortaliB2A3Q6.
SMRiB2A3Q6. Positions 4-554.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2A3Q6-1 [UniParc]FASTAAdd to Basket

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MKSDIEIARG APMRPIKDIA SEVGIKDEEL ELYGDYKAKI TFDAWKRLKD    50
KPDGNLILVT AITPTPAGEG KSTTTVGLGQ ALKRLGKNTM VALREPSLGP 100
SFGVKGGAAG GGYSQVVPME DINLHFTGDI HAITTAHNLL SAAIDNHIHQ 150
GNNLDIDARR INWRRVVDLN DRALRNTVVA LGGRGNGFPR EDGFDITVAS 200
EIMAILCLAT DIKDLKERLS KIIIGYTRDR QPVTVADLKM QGSMAVLLKD 250
AIKPNLVQTY ENVPAFVHGG PFANIAHGCN SAMATQMGVK MSDYLVTEAG 300
FGADLGAEKF FNIKCRFAGL NPDAAVVVAT ARALKMHGGV EKDNLKEENL 350
EALEKGFENL EKHMENINKF GVPAVVAVNR FPTDTEKELE LLINKCQEKG 400
YRVALSEVFA KGGEGGEEVA KEVLDIIDSK ESNFKYLYDV DKSMEEKIET 450
IAKEIYGASD VEFTPTARRN IKQLAQKGLD QVPVCMAKTQ FSFSDDPKLL 500
GRPKDFSITV KRVRISAGAG FAVAMTGDIM TMPGLPKQPA AEEIDIDDDG 550
QITGLF 556
Length:556
Mass (Da):60,470
Last modified:May 20, 2008 - v1
Checksum:i4DDEA3634A3794E8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001034 Genomic DNA. Translation: ACB83682.1.
RefSeqiWP_012446573.1. NC_010718.1.
YP_001916270.1. NC_010718.1.

Genome annotation databases

EnsemblBacteriaiACB83682; ACB83682; Nther_0083.
GeneIDi6316276.
KEGGinth:Nther_0083.
PATRICi22668754. VBINatThe92436_0100.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001034 Genomic DNA. Translation: ACB83682.1 .
RefSeqi WP_012446573.1. NC_010718.1.
YP_001916270.1. NC_010718.1.

3D structure databases

ProteinModelPortali B2A3Q6.
SMRi B2A3Q6. Positions 4-554.
ModBasei Search...

Protein-protein interaction databases

STRINGi 457570.Nther_0083.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACB83682 ; ACB83682 ; Nther_0083 .
GeneIDi 6316276.
KEGGi nth:Nther_0083.
PATRICi 22668754. VBINatThe92436_0100.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci NTHE457570:GHRL-95-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Natranaerobius thermophilus JW/NM-WN-LF."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.
    , Kyrpides N., Lykidis A., Mesbah N.M., Wiegel J.
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF.

Entry informationi

Entry nameiFTHS_NATTJ
AccessioniPrimary (citable) accession number: B2A3Q6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 20, 2008
Last modified: September 3, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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