B2A2U7 (PYRB_NATTJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	Nther_2765

Organism

Natranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF) [Complete proteome] [HAMAP]

Taxonomic identifier

457570 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Natranaerobiales › Natranaerobiaceae › Natranaerobius

Protein attributes

Sequence length	313 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 313	313	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_1000088780

Sequences

	Sequence		Length	Mass (Da)
	B2A2U7 [UniParc]. Last modified May 20, 2008. Version 1. Checksum: E3555D3046CF1AFF	FASTA	313	34,524
	10 20 30 40 50 60 MGLQRKSLLG LKDMEKSEIE SILDSTESMK EIVQRKNKKL PTLKGFSMVN LFYEPSTRTR 70 80 90 100 110 120 SSFEMAGKYL GADTTNMSAS ASSVAKGENL IDTGKTLEAM GINLIVMRHP LAGAPRLLAN 130 140 150 160 170 180 NLSCSIINAG DGYHEHPTQA LLDMFTIKEY KGSLKGLKVT IIGDIYHSRV ARSNIWGLTK 190 200 210 220 230 240 MGADVRLAGP PTLLDQRVFT EMGASCYYRV EDALADADVV MALRIQRERQ GKTLLPSLRE 250 260 270 280 290 300 YARLYGINQE RFKLAKKDAL LLHPGPVNRG IELTSELMNS EKSVIEEQVT NGVAIRMALL 310 YHLSGGEDNG DIA

References

[1]

"Complete sequence of chromosome of Natranaerobius thermophilus JW/NM-WN-LF." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Lykidis A., Mesbah N.M., Wiegel J. Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001034 Genomic DNA. Translation: ACB86315.1.
RefSeq	YP_001918903.1. NC_010718.1.
3D structure databases
ProteinModelPortal	B2A2U7.
ModBase	Search...
Protein-protein interaction databases
STRING	B2A2U7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6315750.
GenomeReviews	Gene locus Nther_2765 in contig CP001034_GR.
KEGG	nth:Nther_2765.
PATRIC	22674337. VBINatThe92436_2845.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG579429.
OMA	VGIPIIN.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
KO	K00609.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. Asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_NATTJ

Accession

Primary (citable) accession number: B2A2U7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	May 20, 2008
Last modified:	January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program