Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

16S rRNA (cytosine(967)-C(5))-methyltransferase

Gene

Nther_1337

Organism
Natranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.SAAS annotation

Catalytic activityi

S-adenosyl-L-methionine + cytosine(967) in 16S rRNA = S-adenosyl-L-homocysteine + 5-methylcytosine(967) in 16S rRNA.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei287S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei314S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei340S-adenosyl-L-methioninePROSITE-ProRule annotation1
Active sitei393NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotationSAAS annotation, RNA-bindingPROSITE-ProRule annotationSAAS annotation, Transferase
Biological processrRNA processingSAAS annotation
LigandS-adenosyl-L-methioninePROSITE-ProRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciNTHE457570:GHRL-1358-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
16S rRNA (cytosine(967)-C(5))-methyltransferaseSAAS annotation (EC:2.1.1.176SAAS annotation)
Gene namesi
Ordered Locus Names:Nther_1337Imported
OrganismiNatranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF)Imported
Taxonomic identifieri457570 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaNatranaerobialesNatranaerobiaceaeNatranaerobius
Proteomesi
  • UP000001683 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi457570.Nther_1337

Structurei

3D structure databases

ProteinModelPortaliB2A2K5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini173 – 459SAM_MT_RSMB_NOPInterPro annotationAdd BLAST287

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni263 – 269S-adenosyl-L-methionine bindingPROSITE-ProRule annotation7

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.PROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CYJ Bacteria
COG0144 LUCA
HOGENOMiHOG000037300
KOiK03500
OMAiLRVNRQH
OrthoDBiPOG091H02E2

Family and domain databases

Gene3Di1.10.940.10, 1 hit
InterProiView protein in InterPro
IPR001678 MeTrfase_RsmB/NOP2
IPR035926 NusB-like_sf
IPR006027 NusB_RsmB_TIM44
IPR023267 RCMT
IPR004573 rRNA_ssu_MeTfrase_B
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF01189 Methyltr_RsmB-F, 1 hit
PF01029 NusB, 1 hit
PRINTSiPR02008 RCMTFAMILY
SUPFAMiSSF48013 SSF48013, 1 hit
SSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00563 rsmB, 1 hit
PROSITEiView protein in PROSITE
PS51686 SAM_MT_RSMB_NOP, 1 hit

Sequencei

Sequence statusi: Complete.

B2A2K5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIKSSRELA FVAYTRIIQD QAYSNLVLNQ LLGKTDLLAQ DKALASRITY
60 70 80 90 100
GTLQWQGLID YYLKTLSHRP LSKLSNKALF LLRMGAYQIL FLDRVPPSAS
110 120 130 140 150
VNETVKVAHR RTHKGIANFV NGILRNLIRK KDQILLPSRD QDLLNYLSVK
160 170 180 190 200
YSHPYWMVKL WYDKYGLDKT ISIMDQNNST PEEAIRVNKL LTSLENLKNE
210 220 230 240 250
LEMTGIQSRL SSKIDDALLV DNLGDLNNNT LFNCGYFQVQ DINSMVVSHL
260 270 280 290 300
CDPQQGDNII DLCSAPGSKT THLVQLIDGQ GSILAVDIHE HRLKLVKEAC
310 320 330 340 350
RRLQVNNVNV KQADGTKLIS RDQQENNKQL KGQFDLCLID APCSGLGTLR
360 370 380 390 400
KRPELKWTIS EQDLNSLSTL QGKLLKAGSQ LVKPGGTLVY STCTINPQEN
410 420 430 440 450
EDQINDFLKN HPDFVMESPR AILKEDTLQG GMILSNNSLQ YFPELNLGDG
460
FYGARMKKTQ CE
Length:462
Mass (Da):52,169
Last modified:May 20, 2008 - v1
Checksum:iD47C5D1A13C1FFFF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001034 Genomic DNA Translation: ACB84920.1
RefSeqiWP_012447795.1, NC_010718.1

Genome annotation databases

EnsemblBacteriaiACB84920; ACB84920; Nther_1337
KEGGinth:Nther_1337

Entry informationi

Entry nameiB2A2K5_NATTJ
AccessioniPrimary (citable) accession number: B2A2K5
Entry historyiIntegrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health