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B1ZWE7 (B1ZWE7_OPITP) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UvrABC system protein B HAMAP-Rule MF_00204

Short name=Protein UvrB HAMAP-Rule MF_00204
Alternative name(s):
Excinuclease ABC subunit B HAMAP-Rule MF_00204
Gene names
Name:uvrB HAMAP-Rule MF_00204
Ordered Locus Names:Oter_3618 EMBL ACB76895.1
OrganismOpitutus terrae (strain DSM 11246 / PB90-1) [Complete proteome] [HAMAP] EMBL ACB76895.1
Taxonomic identifier452637 [NCBI]
Taxonomic lineageBacteriaVerrucomicrobiaOpitutaeOpitutalesOpitutaceaeOpitutus

Protein attributes

Sequence length677 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA2B2 complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage By similarity. HAMAP-Rule MF_00204 SAAS SAAS024759

Subunit structure

Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex By similarity. HAMAP-Rule MF_00204 RuleBase RU003587 SAAS SAAS024759

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00204 RuleBase RU003587 SAAS SAAS024759.

Domain

The beta-hairpin motif is involved in DNA binding By similarity. HAMAP-Rule MF_00204

Sequence similarities

Belongs to the UvrB family. HAMAP-Rule MF_00204 RuleBase RU003587

Contains 1 UVR domain. HAMAP-Rule MF_00204 RuleBase RU003587

Contains 1 helicase ATP-binding domain. HAMAP-Rule MF_00204

Contains 1 helicase C-terminal domain. HAMAP-Rule MF_00204

Contains UVR domain. SAAS SAAS024759

Contains helicase ATP-binding domain. SAAS SAAS024759

Contains helicase C-terminal domain. SAAS SAAS024759

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain24 – 182159Helicase ATP-binding By similarity HAMAP-Rule MF_00204
Domain427 – 580154Helicase C-terminal By similarity HAMAP-Rule MF_00204
Domain615 – 65036UVR By similarity HAMAP-Rule MF_00204
Nucleotide binding37 – 448ATP By similarity HAMAP-Rule MF_00204
Motif90 – 11324Beta-hairpin By similarity HAMAP-Rule MF_00204

Sequences

Sequence LengthMass (Da)Tools
B1ZWE7 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: 64278350A1D42CFA

FASTA67776,846
        10         20         30         40         50         60 
MLFKLHADYQ PTGDQPQAIE QLVASIHAGN RHQTLLGVTG SGKTFTMANV IARCERPTLI 

        70         80         90        100        110        120 
ISHNKTLAAQ LYSEFKNFFP ENAVEYFVSY YDYYQPEAYI ASSDTYIEKD SSINEEIERL 

       130        140        150        160        170        180 
RIAATSSLVS RRDVVVVASV SCIYGLGSPE EFTELRIPLR RGEQLGRHRF LERLVDNIYD 

       190        200        210        220        230        240 
RNDYELKRGT FRVRGDVVDV MPAYLEHGLR VEFFGDEVEA ITEFDPVSGK VLRNLEQFDL 

       250        260        270        280        290        300 
YPANQYVTSR GRLDPAIRSI KAELDERVAY FEQKGQYLEA QRVRMRTNYD LEMLQEMGFC 

       310        320        330        340        350        360 
NGIENYSRHL TGRKAGERPF CLIDFFPKDF LLMIDESHAT VPQIGGMFNG DRARKQTLVD 

       370        380        390        400        410        420 
FGFRLPSALD NRPQTFEEFE QITHQALYVS ATPAEFELKR STVVAEQLVR PTGLLDPEIV 

       430        440        450        460        470        480 
IRPTKGQVEN LIGEIKAAAA AGERVLVTTL TKRLSEDLTS YLREAKIRVE YLHSDIDAIE 

       490        500        510        520        530        540 
RVEILRNLRL GNFDVLIGIN LLREGLDLPE VALVAILDAD KEGFLRSETS LVQTAGRAAR 

       550        560        570        580        590        600 
HEKGRVIFYA DNITESIRRT VEIVKYRREK QLAYNVEHGI TPRSVKRAAQ ASLHVYDGSG 

       610        620        630        640        650        660 
ERDEAAVAEE VDDVAAVIAE LEDEMQEAAG RLEFERAAVL RDQINALKSG EYRKPAKPLA 

       670 
AKYPSRKPRA KASGRRR 

« Hide

References

[1]"Complete sequence of Opitutus terrae PB90-1."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Pitluck S., Goltsman E., Clum A., Sun H., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Smidt H., Richardson P.
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 11246 / PB90-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001032 Genomic DNA. Translation: ACB76895.1.
RefSeqYP_001820495.1. NC_010571.1.

3D structure databases

ProteinModelPortalB1ZWE7.
SMRB1ZWE7. Positions 3-587.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING452637.Oter_3618.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACB76895; ACB76895; Oter_3618.
GeneID6204514.
KEGGote:Oter_3618.
PATRIC22818983. VBIOpiTer17422_3753.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0556.
HOGENOMHOG000073580.
KOK03702.
OMAMQYERND.
OrthoDBEOG6B360R.
ProtClustDBCLSK2800724.

Enzyme and pathway databases

BioCycOTER452637:GHBR-3683-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 4 hits.
4.10.860.10. 1 hit.
HAMAPMF_00204. UvrB.
InterProIPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR001943. UVR_dom.
IPR004807. UvrB.
IPR024759. UvrB_YAD/RRR_dom.
[Graphical view]
PANTHERPTHR24029. PTHR24029. 1 hit.
PfamPF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
PF02151. UVR. 1 hit.
PF12344. UvrB. 1 hit.
[Graphical view]
SMARTSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMSSF46600. SSF46600. 1 hit.
SSF52540. SSF52540. 3 hits.
TIGRFAMsTIGR00631. uvrb. 1 hit.
PROSITEPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50151. UVR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB1ZWE7_OPITP
AccessionPrimary (citable) accession number: B1ZWE7
Entry history
Integrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: April 16, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)