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B1ZWE7

- B1ZWE7_OPITP

UniProt

B1ZWE7 - B1ZWE7_OPITP

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Protein

UvrABC system protein B

Gene

uvrB

Organism
Opitutus terrae (strain DSM 11246 / PB90-1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA2B2 complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.UniRule annotationSAAS annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi37 – 448ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: UniProtKB-HAMAP
  3. excinuclease ABC activity Source: UniProtKB-HAMAP
  4. helicase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. nucleotide-excision repair Source: UniProtKB-HAMAP
  2. SOS response Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Excision nucleaseUniRule annotation, HelicaseUniRule annotation, Hydrolase

Keywords - Biological processi

DNA damage, DNA excisionUniRule annotation, DNA repair, SOS responseUniRule annotation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciOTER452637:GHBR-3683-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein BUniRule annotationSAAS annotation
Short name:
Protein UvrBUniRule annotation
Alternative name(s):
Excinuclease ABC subunit BUniRule annotation
Gene namesi
Name:uvrBUniRule annotation
Ordered Locus Names:Oter_3618Imported
OrganismiOpitutus terrae (strain DSM 11246 / PB90-1)Imported
Taxonomic identifieri452637 [NCBI]
Taxonomic lineageiBacteriaVerrucomicrobiaOpitutaeOpitutalesOpitutaceaeOpitutus
ProteomesiUP000007013: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi452637.Oter_3618.

Structurei

3D structure databases

ProteinModelPortaliB1ZWE7.
SMRiB1ZWE7. Positions 3-587.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 182159Helicase ATP-bindingUniRule annotationAdd
BLAST
Domaini427 – 580154Helicase C-terminalUniRule annotationAdd
BLAST
Domaini615 – 65036UVRUniRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi90 – 11324Beta-hairpinUniRule annotationAdd
BLAST

Domaini

The beta-hairpin motif is involved in DNA binding.UniRule annotation

Sequence similaritiesi

Belongs to the UvrB family.UniRule annotation
Contains 1 UVR domain.UniRule annotation
Contains 1 helicase ATP-binding domain.UniRule annotation
Contains 1 helicase C-terminal domain.UniRule annotation
Contains UVR domain.SAAS annotation
Contains helicase ATP-binding domain.SAAS annotation
Contains helicase C-terminal domain.SAAS annotation

Phylogenomic databases

eggNOGiCOG0556.
HOGENOMiHOG000073580.
KOiK03702.
OMAiLEKQMHE.
OrthoDBiEOG6B360R.

Family and domain databases

Gene3Di3.40.50.300. 4 hits.
4.10.860.10. 1 hit.
HAMAPiMF_00204. UvrB.
InterProiIPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR001943. UVR_dom.
IPR004807. UvrB.
IPR024759. UvrB_YAD/RRR_dom.
[Graphical view]
PANTHERiPTHR24029. PTHR24029. 1 hit.
PfamiPF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
PF02151. UVR. 1 hit.
PF12344. UvrB. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF52540. SSF52540. 3 hits.
TIGRFAMsiTIGR00631. uvrb. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50151. UVR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1ZWE7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLFKLHADYQ PTGDQPQAIE QLVASIHAGN RHQTLLGVTG SGKTFTMANV
60 70 80 90 100
IARCERPTLI ISHNKTLAAQ LYSEFKNFFP ENAVEYFVSY YDYYQPEAYI
110 120 130 140 150
ASSDTYIEKD SSINEEIERL RIAATSSLVS RRDVVVVASV SCIYGLGSPE
160 170 180 190 200
EFTELRIPLR RGEQLGRHRF LERLVDNIYD RNDYELKRGT FRVRGDVVDV
210 220 230 240 250
MPAYLEHGLR VEFFGDEVEA ITEFDPVSGK VLRNLEQFDL YPANQYVTSR
260 270 280 290 300
GRLDPAIRSI KAELDERVAY FEQKGQYLEA QRVRMRTNYD LEMLQEMGFC
310 320 330 340 350
NGIENYSRHL TGRKAGERPF CLIDFFPKDF LLMIDESHAT VPQIGGMFNG
360 370 380 390 400
DRARKQTLVD FGFRLPSALD NRPQTFEEFE QITHQALYVS ATPAEFELKR
410 420 430 440 450
STVVAEQLVR PTGLLDPEIV IRPTKGQVEN LIGEIKAAAA AGERVLVTTL
460 470 480 490 500
TKRLSEDLTS YLREAKIRVE YLHSDIDAIE RVEILRNLRL GNFDVLIGIN
510 520 530 540 550
LLREGLDLPE VALVAILDAD KEGFLRSETS LVQTAGRAAR HEKGRVIFYA
560 570 580 590 600
DNITESIRRT VEIVKYRREK QLAYNVEHGI TPRSVKRAAQ ASLHVYDGSG
610 620 630 640 650
ERDEAAVAEE VDDVAAVIAE LEDEMQEAAG RLEFERAAVL RDQINALKSG
660 670
EYRKPAKPLA AKYPSRKPRA KASGRRR
Length:677
Mass (Da):76,846
Last modified:May 20, 2008 - v1
Checksum:i64278350A1D42CFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001032 Genomic DNA. Translation: ACB76895.1.
RefSeqiWP_012376424.1. NC_010571.1.
YP_001820495.1. NC_010571.1.

Genome annotation databases

EnsemblBacteriaiACB76895; ACB76895; Oter_3618.
GeneIDi6204514.
KEGGiote:Oter_3618.
PATRICi22818983. VBIOpiTer17422_3753.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001032 Genomic DNA. Translation: ACB76895.1 .
RefSeqi WP_012376424.1. NC_010571.1.
YP_001820495.1. NC_010571.1.

3D structure databases

ProteinModelPortali B1ZWE7.
SMRi B1ZWE7. Positions 3-587.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 452637.Oter_3618.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACB76895 ; ACB76895 ; Oter_3618 .
GeneIDi 6204514.
KEGGi ote:Oter_3618.
PATRICi 22818983. VBIOpiTer17422_3753.

Phylogenomic databases

eggNOGi COG0556.
HOGENOMi HOG000073580.
KOi K03702.
OMAi LEKQMHE.
OrthoDBi EOG6B360R.

Enzyme and pathway databases

BioCyci OTER452637:GHBR-3683-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 4 hits.
4.10.860.10. 1 hit.
HAMAPi MF_00204. UvrB.
InterProi IPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR001943. UVR_dom.
IPR004807. UvrB.
IPR024759. UvrB_YAD/RRR_dom.
[Graphical view ]
PANTHERi PTHR24029. PTHR24029. 1 hit.
Pfami PF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
PF02151. UVR. 1 hit.
PF12344. UvrB. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view ]
SUPFAMi SSF46600. SSF46600. 1 hit.
SSF52540. SSF52540. 3 hits.
TIGRFAMsi TIGR00631. uvrb. 1 hit.
PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50151. UVR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 11246 / PB90-1Imported.

Entry informationi

Entry nameiB1ZWE7_OPITP
AccessioniPrimary (citable) accession number: B1ZWE7
Entry historyi
Integrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: November 26, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3