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Protein

UvrABC system protein B

Gene

uvrB

Organism
Opitutus terrae (strain DSM 11246 / JCM 15787 / PB90-1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA2B2 complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.UniRule annotationSAAS annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi37 – 44ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExcision nucleaseUniRule annotationSAAS annotation
Biological processDNA damage, DNA excisionUniRule annotationSAAS annotation, DNA repair, SOS responseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciOTER452637:G1GBP-3687-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein BUniRule annotationSAAS annotation
Short name:
Protein UvrBUniRule annotation
Alternative name(s):
Excinuclease ABC subunit BUniRule annotation
Gene namesi
Name:uvrBUniRule annotation
Ordered Locus Names:Oter_3618Imported
OrganismiOpitutus terrae (strain DSM 11246 / JCM 15787 / PB90-1)Imported
Taxonomic identifieri452637 [NCBI]
Taxonomic lineageiBacteriaVerrucomicrobiaOpitutaeOpitutalesOpitutaceaeOpitutus
Proteomesi
  • UP000007013 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi452637.Oter_3618

Structurei

3D structure databases

ProteinModelPortaliB1ZWE7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 182Helicase ATP-bindingInterPro annotationAdd BLAST159
Domaini427 – 580Helicase C-terminalInterPro annotationAdd BLAST154
Domaini615 – 650UVRInterPro annotationAdd BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili611 – 638Sequence analysisAdd BLAST28

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi90 – 113Beta-hairpinUniRule annotationAdd BLAST24

Domaini

The beta-hairpin motif is involved in DNA binding.UniRule annotation

Sequence similaritiesi

Belongs to the UvrB family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG4105CCW Bacteria
COG0556 LUCA
HOGENOMiHOG000073580
KOiK03702
OMAiRYMHSEI
OrthoDBiPOG091H02LK

Family and domain databases

CDDicd00079 HELICc, 1 hit
HAMAPiMF_00204 UvrB, 1 hit
InterProiView protein in InterPro
IPR006935 Helicase/UvrB_N
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR001943 UVR_dom
IPR036876 UVR_dom_sf
IPR004807 UvrB
IPR024759 UvrB_YAD/RRR_dom
PANTHERiPTHR24029 PTHR24029, 1 hit
PfamiView protein in Pfam
PF00271 Helicase_C, 1 hit
PF04851 ResIII, 1 hit
PF02151 UVR, 1 hit
PF12344 UvrB, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF46600 SSF46600, 1 hit
SSF52540 SSF52540, 3 hits
TIGRFAMsiTIGR00631 uvrb, 1 hit
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50151 UVR, 1 hit

Sequencei

Sequence statusi: Complete.

B1ZWE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFKLHADYQ PTGDQPQAIE QLVASIHAGN RHQTLLGVTG SGKTFTMANV
60 70 80 90 100
IARCERPTLI ISHNKTLAAQ LYSEFKNFFP ENAVEYFVSY YDYYQPEAYI
110 120 130 140 150
ASSDTYIEKD SSINEEIERL RIAATSSLVS RRDVVVVASV SCIYGLGSPE
160 170 180 190 200
EFTELRIPLR RGEQLGRHRF LERLVDNIYD RNDYELKRGT FRVRGDVVDV
210 220 230 240 250
MPAYLEHGLR VEFFGDEVEA ITEFDPVSGK VLRNLEQFDL YPANQYVTSR
260 270 280 290 300
GRLDPAIRSI KAELDERVAY FEQKGQYLEA QRVRMRTNYD LEMLQEMGFC
310 320 330 340 350
NGIENYSRHL TGRKAGERPF CLIDFFPKDF LLMIDESHAT VPQIGGMFNG
360 370 380 390 400
DRARKQTLVD FGFRLPSALD NRPQTFEEFE QITHQALYVS ATPAEFELKR
410 420 430 440 450
STVVAEQLVR PTGLLDPEIV IRPTKGQVEN LIGEIKAAAA AGERVLVTTL
460 470 480 490 500
TKRLSEDLTS YLREAKIRVE YLHSDIDAIE RVEILRNLRL GNFDVLIGIN
510 520 530 540 550
LLREGLDLPE VALVAILDAD KEGFLRSETS LVQTAGRAAR HEKGRVIFYA
560 570 580 590 600
DNITESIRRT VEIVKYRREK QLAYNVEHGI TPRSVKRAAQ ASLHVYDGSG
610 620 630 640 650
ERDEAAVAEE VDDVAAVIAE LEDEMQEAAG RLEFERAAVL RDQINALKSG
660 670
EYRKPAKPLA AKYPSRKPRA KASGRRR
Length:677
Mass (Da):76,846
Last modified:May 20, 2008 - v1
Checksum:i64278350A1D42CFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001032 Genomic DNA Translation: ACB76895.1
RefSeqiWP_012376424.1, NC_010571.1

Genome annotation databases

EnsemblBacteriaiACB76895; ACB76895; Oter_3618
KEGGiote:Oter_3618

Similar proteinsi

Entry informationi

Entry nameiB1ZWE7_OPITP
AccessioniPrimary (citable) accession number: B1ZWE7
Entry historyiIntegrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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