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B1ZWE7

- B1ZWE7_OPITP

UniProt

B1ZWE7 - B1ZWE7_OPITP

Protein

UvrABC system protein B

Gene

uvrB

Organism
Opitutus terrae (strain DSM 11246 / PB90-1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (20 May 2008)
      Previous versions | rss
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    Functioni

    The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA2B2 complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.UniRule annotationSAAS annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi37 – 448ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: UniProtKB-HAMAP
    3. excinuclease ABC activity Source: UniProtKB-HAMAP
    4. helicase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. nucleotide-excision repair Source: UniProtKB-HAMAP
    2. SOS response Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Excision nucleaseUniRule annotationSAAS annotation, HelicaseUniRule annotation, Hydrolase

    Keywords - Biological processi

    DNA damage, DNA excisionUniRule annotationSAAS annotation, DNA repair, SOS responseUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciOTER452637:GHBR-3683-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UvrABC system protein BUniRule annotation
    Short name:
    Protein UvrBUniRule annotation
    Alternative name(s):
    Excinuclease ABC subunit BUniRule annotation
    Gene namesi
    Name:uvrBUniRule annotation
    Ordered Locus Names:Oter_3618Imported
    OrganismiOpitutus terrae (strain DSM 11246 / PB90-1)Imported
    Taxonomic identifieri452637 [NCBI]
    Taxonomic lineageiBacteriaVerrucomicrobiaOpitutaeOpitutalesOpitutaceaeOpitutus
    ProteomesiUP000007013: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.UniRule annotationSAAS annotation

    Protein-protein interaction databases

    STRINGi452637.Oter_3618.

    Structurei

    3D structure databases

    ProteinModelPortaliB1ZWE7.
    SMRiB1ZWE7. Positions 3-587.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 182159Helicase ATP-bindingUniRule annotationAdd
    BLAST
    Domaini427 – 580154Helicase C-terminalUniRule annotationAdd
    BLAST
    Domaini615 – 65036UVRUniRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi90 – 11324Beta-hairpinUniRule annotationAdd
    BLAST

    Domaini

    The beta-hairpin motif is involved in DNA binding.UniRule annotation

    Sequence similaritiesi

    Belongs to the UvrB family.UniRule annotation
    Contains 1 UVR domain.UniRule annotation
    Contains 1 helicase ATP-binding domain.UniRule annotation
    Contains 1 helicase C-terminal domain.UniRule annotation
    Contains UVR domain.SAAS annotation
    Contains helicase ATP-binding domain.SAAS annotation
    Contains helicase C-terminal domain.SAAS annotation

    Phylogenomic databases

    eggNOGiCOG0556.
    HOGENOMiHOG000073580.
    KOiK03702.
    OMAiLEKQMHE.
    OrthoDBiEOG6B360R.

    Family and domain databases

    Gene3Di3.40.50.300. 4 hits.
    4.10.860.10. 1 hit.
    HAMAPiMF_00204. UvrB.
    InterProiIPR006935. Helicase/UvrB_dom.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR001943. UVR_dom.
    IPR004807. UvrB.
    IPR024759. UvrB_YAD/RRR_dom.
    [Graphical view]
    PANTHERiPTHR24029. PTHR24029. 1 hit.
    PfamiPF00271. Helicase_C. 1 hit.
    PF04851. ResIII. 1 hit.
    PF02151. UVR. 1 hit.
    PF12344. UvrB. 1 hit.
    [Graphical view]
    SMARTiSM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view]
    SUPFAMiSSF46600. SSF46600. 1 hit.
    SSF52540. SSF52540. 3 hits.
    TIGRFAMsiTIGR00631. uvrb. 1 hit.
    PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS50151. UVR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1ZWE7-1 [UniParc]FASTAAdd to Basket

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    MLFKLHADYQ PTGDQPQAIE QLVASIHAGN RHQTLLGVTG SGKTFTMANV    50
    IARCERPTLI ISHNKTLAAQ LYSEFKNFFP ENAVEYFVSY YDYYQPEAYI 100
    ASSDTYIEKD SSINEEIERL RIAATSSLVS RRDVVVVASV SCIYGLGSPE 150
    EFTELRIPLR RGEQLGRHRF LERLVDNIYD RNDYELKRGT FRVRGDVVDV 200
    MPAYLEHGLR VEFFGDEVEA ITEFDPVSGK VLRNLEQFDL YPANQYVTSR 250
    GRLDPAIRSI KAELDERVAY FEQKGQYLEA QRVRMRTNYD LEMLQEMGFC 300
    NGIENYSRHL TGRKAGERPF CLIDFFPKDF LLMIDESHAT VPQIGGMFNG 350
    DRARKQTLVD FGFRLPSALD NRPQTFEEFE QITHQALYVS ATPAEFELKR 400
    STVVAEQLVR PTGLLDPEIV IRPTKGQVEN LIGEIKAAAA AGERVLVTTL 450
    TKRLSEDLTS YLREAKIRVE YLHSDIDAIE RVEILRNLRL GNFDVLIGIN 500
    LLREGLDLPE VALVAILDAD KEGFLRSETS LVQTAGRAAR HEKGRVIFYA 550
    DNITESIRRT VEIVKYRREK QLAYNVEHGI TPRSVKRAAQ ASLHVYDGSG 600
    ERDEAAVAEE VDDVAAVIAE LEDEMQEAAG RLEFERAAVL RDQINALKSG 650
    EYRKPAKPLA AKYPSRKPRA KASGRRR 677
    Length:677
    Mass (Da):76,846
    Last modified:May 20, 2008 - v1
    Checksum:i64278350A1D42CFA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001032 Genomic DNA. Translation: ACB76895.1.
    RefSeqiWP_012376424.1. NC_010571.1.
    YP_001820495.1. NC_010571.1.

    Genome annotation databases

    EnsemblBacteriaiACB76895; ACB76895; Oter_3618.
    GeneIDi6204514.
    KEGGiote:Oter_3618.
    PATRICi22818983. VBIOpiTer17422_3753.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001032 Genomic DNA. Translation: ACB76895.1 .
    RefSeqi WP_012376424.1. NC_010571.1.
    YP_001820495.1. NC_010571.1.

    3D structure databases

    ProteinModelPortali B1ZWE7.
    SMRi B1ZWE7. Positions 3-587.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 452637.Oter_3618.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACB76895 ; ACB76895 ; Oter_3618 .
    GeneIDi 6204514.
    KEGGi ote:Oter_3618.
    PATRICi 22818983. VBIOpiTer17422_3753.

    Phylogenomic databases

    eggNOGi COG0556.
    HOGENOMi HOG000073580.
    KOi K03702.
    OMAi LEKQMHE.
    OrthoDBi EOG6B360R.

    Enzyme and pathway databases

    BioCyci OTER452637:GHBR-3683-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 4 hits.
    4.10.860.10. 1 hit.
    HAMAPi MF_00204. UvrB.
    InterProi IPR006935. Helicase/UvrB_dom.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR001943. UVR_dom.
    IPR004807. UvrB.
    IPR024759. UvrB_YAD/RRR_dom.
    [Graphical view ]
    PANTHERi PTHR24029. PTHR24029. 1 hit.
    Pfami PF00271. Helicase_C. 1 hit.
    PF04851. ResIII. 1 hit.
    PF02151. UVR. 1 hit.
    PF12344. UvrB. 1 hit.
    [Graphical view ]
    SMARTi SM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46600. SSF46600. 1 hit.
    SSF52540. SSF52540. 3 hits.
    TIGRFAMsi TIGR00631. uvrb. 1 hit.
    PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS50151. UVR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 11246 / PB90-1Imported.

    Entry informationi

    Entry nameiB1ZWE7_OPITP
    AccessioniPrimary (citable) accession number: B1ZWE7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 20, 2008
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3