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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Opitutus terrae (strain DSM 11246 / JCM 15787 / PB90-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei228ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciOTER452637:G1GBP-2710-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:Oter_2646
OrganismiOpitutus terrae (strain DSM 11246 / JCM 15787 / PB90-1)
Taxonomic identifieri452637 [NCBI]
Taxonomic lineageiBacteriaVerrucomicrobiaOpitutaeOpitutalesOpitutaceaeOpitutus
Proteomesi
  • UP000007013 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003677241 – 460Glutamate--tRNA ligaseAdd BLAST460

Proteomic databases

PRIDEiB1ZUV7

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi452637.Oter_2646

Structurei

3D structure databases

ProteinModelPortaliB1ZUV7
SMRiB1ZUV7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi10 – 20"HIGH" regionUniRule annotationAdd BLAST11
Motifi225 – 229"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252720
KOiK01885
OMAiAYYAFDT
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 2 hits
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 2 hits
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit

Sequencei

Sequence statusi: Complete.

B1ZUV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHVRVRFAP SPTGFFHIGS ARTALFNWLY ARHTGGTFVL RIEDTDKERN
60 70 80 90 100
SEAFLNVIYD SLRWLGMEWD EGPGKGGEFG PYRQSERDAV YREYLAKLTA
110 120 130 140 150
AGRTYEKDGA IWFKLLGERY EVFDEHRKKT VTKVKTAPTV IEDRIRGRVE
160 170 180 190 200
RVEDEDFVIF RSDGNPVFHF VNVVDDIAMQ ITHVIRGEDH LSNTSKHVEL
210 220 230 240 250
FKAFGAPVPQ FAHIPLILKQ NGPGKMSKRD QGALIEEYQR RGYLSEALVN
260 270 280 290 300
FLSLLGWNPG DDREKMPIAE IIRLFDLPGV NQSNARFDDK KLAHMNMAYL
310 320 330 340 350
LELPADTFVQ KARAFFESLG DNATAKAALA AEPAFFREVM LLSQPKIKGF
360 370 380 390 400
EELPAYTAYF FTDEFATDAK VRDKVMGKGD PKARLRELIE ALPGFDFSND
410 420 430 440 450
AAVEEGIKVL ATKNALGFGD YQSVARLGVS GTNVGPSITG MFRVLGRERV
460
RARLERLLNA
Length:460
Mass (Da):51,927
Last modified:May 20, 2008 - v1
Checksum:iC1F34FE57EB80CBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001032 Genomic DNA Translation: ACB75927.1
RefSeqiWP_012375462.1, NC_010571.1

Genome annotation databases

EnsemblBacteriaiACB75927; ACB75927; Oter_2646
KEGGiote:Oter_2646

Similar proteinsi

Entry informationi

Entry nameiSYE_OPITP
AccessioniPrimary (citable) accession number: B1ZUV7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: May 23, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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