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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Opitutus terrae (strain DSM 11246 / JCM 15787 / PB90-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase 1 (Oter_2141)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei189May be catalytically importantUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciOTER452637:G1GBP-1616-MONOMER
UniPathwayiUPA00848; UER00151

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:Oter_1567
OrganismiOpitutus terrae (strain DSM 11246 / JCM 15787 / PB90-1)
Taxonomic identifieri452637 [NCBI]
Taxonomic lineageiBacteriaVerrucomicrobiaOpitutaeOpitutalesOpitutaceaeOpitutus
Proteomesi
  • UP000007013 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003720321 – 327GTP cyclohydrolase FolE2Add BLAST327

Interactioni

Protein-protein interaction databases

STRINGi452637.Oter_1567

Structurei

3D structure databases

ProteinModelPortaliB1ZTR5
SMRiB1ZTR5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DZA Bacteria
COG1469 LUCA
HOGENOMiHOG000247517
KOiK09007
OMAiHNQRGRG
OrthoDBiPOG091H0MIO

Family and domain databases

HAMAPiMF_01527_B GTP_cyclohydrol_B, 1 hit
InterProiView protein in InterPro
IPR022838 GTP_cyclohydrolase_FolE2
IPR003801 GTP_cyclohydrolase_FolE2/MptA
PANTHERiPTHR36445 PTHR36445, 1 hit
PfamiView protein in Pfam
PF02649 GCHY-1, 1 hit

Sequencei

Sequence statusi: Complete.

B1ZTR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKKKKSMYL HESASGAAPK IQRRYDPAFE VDAAYRASLP DMMEAAYAAI
60 70 80 90 100
QGAHVPIQQV GVSNFKLPLK FRTKKGEILT LEASITGTVS LEADLKGINM
110 120 130 140 150
SRIVRSFYDH KDEVFTGEWM GKILCAYLRN VKSKDARLKV SFSYPMLHRS
160 170 180 190 200
LRSGLEGYQF YNVAFEGVLT RKGDYRRFIH FDFVYSSACP CSAELAEHAR
210 220 230 240 250
DQRGVYSVPH SQRSKARIVV EETQGKKIWI EDVHAHCLRA LQTETQVMVK
260 270 280 290 300
REDEQAFAEL NGAHLKFVED AARLLYREFD ADEKIADFRI ACSHLESLHS
310 320
HDAVSVICKG VKGGFTADFM DFQSLVC
Length:327
Mass (Da):37,024
Last modified:May 20, 2008 - v1
Checksum:iCEC01A4865E5D86B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001032 Genomic DNA Translation: ACB74851.1
RefSeqiWP_012374389.1, NC_010571.1

Genome annotation databases

EnsemblBacteriaiACB74851; ACB74851; Oter_1567
KEGGiote:Oter_1567

Similar proteinsi

Entry informationi

Entry nameiGCH4_OPITP
AccessioniPrimary (citable) accession number: B1ZTR5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 20, 2008
Last modified: March 28, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health