Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

B1ZTR5 (GCH4_OPITP) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase FolE2

EC=3.5.4.16
Gene names
Name:folE2
Ordered Locus Names:Oter_1567
OrganismOpitutus terrae (strain DSM 11246 / PB90-1) [Complete proteome] [HAMAP]
Taxonomic identifier452637 [NCBI]
Taxonomic lineageBacteriaVerrucomicrobiaOpitutaeOpitutalesOpitutaceaeOpitutus

Protein attributes

Sequence length327 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process7,8-dihydroneopterin 3'-triphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionGTP cyclohydrolase I activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 327327GTP cyclohydrolase FolE2 HAMAP-Rule MF_01527
PRO_0000372032

Sites

Site1891May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
B1ZTR5 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: CEC01A4865E5D86B

FASTA32737,024
        10         20         30         40         50         60 
MSKKKKSMYL HESASGAAPK IQRRYDPAFE VDAAYRASLP DMMEAAYAAI QGAHVPIQQV 

        70         80         90        100        110        120 
GVSNFKLPLK FRTKKGEILT LEASITGTVS LEADLKGINM SRIVRSFYDH KDEVFTGEWM 

       130        140        150        160        170        180 
GKILCAYLRN VKSKDARLKV SFSYPMLHRS LRSGLEGYQF YNVAFEGVLT RKGDYRRFIH 

       190        200        210        220        230        240 
FDFVYSSACP CSAELAEHAR DQRGVYSVPH SQRSKARIVV EETQGKKIWI EDVHAHCLRA 

       250        260        270        280        290        300 
LQTETQVMVK REDEQAFAEL NGAHLKFVED AARLLYREFD ADEKIADFRI ACSHLESLHS 

       310        320 
HDAVSVICKG VKGGFTADFM DFQSLVC 

« Hide

References

[1]"Genome sequence of the verrucomicrobium Opitutus terrae PB90-1, an abundant inhabitant of rice paddy soil ecosystems."
van Passel M.W., Kant R., Palva A., Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Pitluck S., Goltsman E., Clum A., Sun H., Schmutz J., Larimer F.W., Land M.L., Hauser L., Kyrpides N., Mikhailova N., Richardson P.P. expand/collapse author list , Janssen P.H., de Vos W.M., Smidt H.
J. Bacteriol. 193:2367-2368(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 11246 / PB90-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001032 Genomic DNA. Translation: ACB74851.1.
RefSeqYP_001818451.1. NC_010571.1.

3D structure databases

ProteinModelPortalB1ZTR5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING452637.Oter_1567.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACB74851; ACB74851; Oter_1567.
GeneID6208835.
KEGGote:Oter_1567.
PATRIC22814661. VBIOpiTer17422_1625.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1469.
HOGENOMHOG000247517.
KOK09007.
OMANQRAEVT.
OrthoDBEOG6X6RBH.

Enzyme and pathway databases

BioCycOTER452637:GHBR-1598-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_01527_B. GTP_cyclohydrol_B.
InterProIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH4_OPITP
AccessionPrimary (citable) accession number: B1ZTR5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 20, 2008
Last modified: May 14, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways