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B1ZS98

- PNP_OPITP

UniProt

B1ZS98 - PNP_OPITP

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Opitutus terrae (strain DSM 11246 / PB90-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi494 – 4941MagnesiumUniRule annotation
Metal bindingi500 – 5001MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciOTER452637:GHBR-2466-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Oter_2415
OrganismiOpitutus terrae (strain DSM 11246 / PB90-1)
Taxonomic identifieri452637 [NCBI]
Taxonomic lineageiBacteriaVerrucomicrobiaOpitutaeOpitutalesOpitutaceaeOpitutus
ProteomesiUP000007013: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 730730Polyribonucleotide nucleotidyltransferasePRO_0000381908Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi452637.Oter_2415.

Structurei

3D structure databases

ProteinModelPortaliB1ZS98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini561 – 62262KHUniRule annotationAdd
BLAST
Domaini642 – 71170S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 1 hit.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1ZS98-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNQKYSVTVP ELGITFSTGS IAQLANGAVN VQVGETNVFV TACVAQTTKP
60 70 80 90 100
GQDWFPLTVD YREKYAAAGR FPGGYFKREG RPSEKEILTS RLCDRPCRPL
110 120 130 140 150
FPEGFLNEVQ IIGQLFSADL VNESDISMVN GASAALAISD IPWNGPIAAV
160 170 180 190 200
RVAEIEGKFV ANPTIDQMFA SSLDLIYVGN EKDMLMIEGS ADQIPEERFI
210 220 230 240 250
EALAFGHESI QPILKAIKEL VAQCGKPKGT FPLVGATPEA RTIIERVVPT
260 270 280 290 300
ERLIEAIFGK EKAVRANAVK LLKEEAKAAL TAELGEGKFT DVDLNVVFED
310 320 330 340 350
LQYKAYRKTV LERGVRADGR GQKDIRPLQA QVGVLPRVHG SAMFQRGDTQ
360 370 380 390 400
NIALTTLGPT KDAQDLDALT GGVKSKSFLL HYNFPPFSVG ETGRFTGPGR
410 420 430 440 450
REIGHGALAE RSLVPVLPPE DVFPYSIRVV SEIMASNGST SMASICGGCL
460 470 480 490 500
SLMDAGVPII APVAGISCGL MTQNASDGSI EKWVTITDIL GEEDHFGDMD
510 520 530 540 550
FKLAGTSKGI TGFQLDLKIN GLPFEIAKTA IMQARDARME ILKVMLGSLP
560 570 580 590 600
APRADLSKYA PRIQTIQIDP EKIGLLIGPG GKTIRRITET TGAQIDIAED
610 620 630 640 650
DSGKVFVYSN NAEAMNRAIQ EIDSLCGGGG PGGSKGPAIE VGKIYTGRVT
660 670 680 690 700
GVKEFGCFVE CTPGNEGLCH VSELADFRVR RTEDVVKMGD SITVKCIGID
710 720 730
ERSGKVRLSR KAAMKELEAQ KQSSEAAPAQ
Length:730
Mass (Da):78,463
Last modified:May 20, 2008 - v1
Checksum:i8D75403DC2DF0304
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001032 Genomic DNA. Translation: ACB75697.1.
RefSeqiWP_012375233.1. NC_010571.1.
YP_001819297.1. NC_010571.1.

Genome annotation databases

EnsemblBacteriaiACB75697; ACB75697; Oter_2415.
GeneIDi6207731.
KEGGiote:Oter_2415.
PATRICi22816489. VBIOpiTer17422_2519.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001032 Genomic DNA. Translation: ACB75697.1 .
RefSeqi WP_012375233.1. NC_010571.1.
YP_001819297.1. NC_010571.1.

3D structure databases

ProteinModelPortali B1ZS98.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 452637.Oter_2415.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACB75697 ; ACB75697 ; Oter_2415 .
GeneIDi 6207731.
KEGGi ote:Oter_2415.
PATRICi 22816489. VBIOpiTer17422_2519.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci OTER452637:GHBR-2466-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 1 hit.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 11246 / PB90-1.

Entry informationi

Entry nameiPNP_OPITP
AccessioniPrimary (citable) accession number: B1ZS98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: May 20, 2008
Last modified: November 26, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3