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B1ZRV8 (B1ZRV8_OPITP) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Malate dehydrogenase HAMAP-Rule MF_01517
EC=1.1.1.37 HAMAP-Rule MF_01517
Gene names
Name:mdh HAMAP-Rule MF_01517
Ordered Locus Names:Oter_0511
OrganismOpitutus terrae (strain DSM 11246 / PB90-1) [Complete proteome] [HAMAP] EMBL ACB73801.1
Taxonomic identifier452637 [NCBI]
Taxonomic lineageBacteria › Verrucomicrobia › Opitutae › Opitutales › Opitutaceae › Opitutus ›

Protein attributes

Sequence length329 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity. HAMAP-Rule MF_01517

Catalytic activity

(S)-malate + NAD+ = oxaloacetate + NADH. HAMAP-Rule MF_01517 SAAS SAAS010945

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01517 SAAS SAAS010945

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 2 family. HAMAP-Rule MF_01517

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding13 – 197NAD By similarity HAMAP-Rule MF_01517
Nucleotide binding133 – 1353NAD By similarity HAMAP-Rule MF_01517

Sites

Active site1911Proton acceptor By similarity HAMAP-Rule MF_01517
Binding site961Substrate By similarity HAMAP-Rule MF_01517
Binding site1021Substrate By similarity HAMAP-Rule MF_01517
Binding site1091NAD By similarity HAMAP-Rule MF_01517
Binding site1161NAD By similarity HAMAP-Rule MF_01517
Binding site1351Substrate By similarity HAMAP-Rule MF_01517
Binding site1661Substrate By similarity HAMAP-Rule MF_01517

Sequences

Sequence LengthMass (Da)Tools
B1ZRV8 [UniParc].

Last modified May 20, 2008. Version 1.
Checksum: 7A8A6BAB63AD5201

FASTA32934,607
        10         20         30         40         50         60 
MAMKPPIRVA VTGAAGQIGY ALLFRIASGA MFGADQPVIL QLIEAPFEKA MKALEGVAME 

        70         80         90        100        110        120 
LDDCAFPLLK GIVQTDKPEV GFKDANWCLL IGAKPRGPGM ERADLLKDNG KIFIGQGQII 

       130        140        150        160        170        180 
DAVAAADARV AVVGNPANTN CMIAASQAKR LPAERFTAMV RLDQNRAQTQ LAKKAGVDLT 

       190        200        210        220        230        240 
AVKDIFIYGN HSPSMFPSFA HATINGKPAT SVITDTAWLQ GPFCETVGKR GAAIIAARGA 

       250        260        270        280        290        300 
SSAASAANAL VDHVRSLVTP GAVHSIAVKS NGAYGFDANV WAGMPVRTTT PGSYEVITGY 

       310        320 
AMDDFAKSKL AATNKELVEE RAFVADMIK

« Hide

References

[1]"Complete sequence of Opitutus terrae PB90-1."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Pitluck S., Goltsman E., Clum A., Sun H., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Smidt H., Richardson P.
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 11246 / PB90-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001032 Genomic DNA. Translation: ACB73801.1.
RefSeqYP_001817401.1. NC_010571.1.

3D structure databases

ProteinModelPortalB1ZRV8.
SMRB1ZRV8. Positions 4-326.
ModBaseSearch...

Protein-protein interaction databases

STRING452637.Oter_0511.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACB73801; ACB73801; Oter_0511.
GeneID6206832.
KEGGote:Oter_0511.
PATRIC22812431. VBIOpiTer17422_0535.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0039.
HOGENOMHOG000220953.
KOK00024.
OMAAINDHAA.
ProtClustDBPRK05442.

Enzyme and pathway databases

BioCycOTER452637:GHBR-515-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPMF_01517. Malate_dehydrog_2.
InterProIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR23382. PTHR23382. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMSSF56327. Lactate_DH/Glyco_hydro_4_C. 1 hit.
TIGRFAMsTIGR01759. MalateDH-SF1. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB1ZRV8_OPITP
AccessionPrimary (citable) accession number: B1ZRV8
Entry history
Integrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: May 1, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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